Development of T-cell engagers selective for cells co-expressing two antigens

por Dicara, Danielle M., Bhakta, Sunil, Go, Mary Ann, Ziai, James, Firestein, Ron, Forrest, Bill, Gu, Chen, Leong, Steven R., Lee, Genee, Yu, Shang-Fan, Polson, Andrew G., Agard, Nicholas J.
Publicado 2022

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

por Cuellar, Trinna L., Barnes, Dwight, Nelson, Christopher, Tanguay, Joshua, Yu, Shang-Fan, Wen, Xiaohui, Scales, Suzie J., Gesch, Julie, Davis, David, van Brabant Smith, Anja, Leake, Devin, Vandlen, Richard, Siebel, Christian W.
Publicado 2015

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

por Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R., Flygare, John A.
Publicado 2017

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates

por Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S., Pillow, Thomas H., Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D., Erickson, Hans K., Hop, Cornelis E. C. A., Khojasteh, S. Cyrus
Publicado 2016

Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging

por Mandikian, Danielle, Rafidi, Hanine, Adhikari, Pragya, Venkatraman, Priya, Nazarova, Lidia, Fung, Gabriel, Figueroa, Isabel, Ferl, Gregory Z., Ulufatu, Sheila, Ho, Jason, McCaughey, Cynthia, Lau, Jeffrey, Yu, Shang-Fan, Prabhu, Saileta, Sadowsky, Jack, Boswell, C. Andrew
Publicado 2018

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

por Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
Publicado 2019

Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin

por Li, Dongwei, Lee, Donna, Dere, Randall C., Zheng, Bing, Yu, Shang‐Fan, Fuh, Franklin K., Kozak, Katherine R., Chung, Shan, Bumbaca Yadav, Daniela, Nazzal, Denise, Danilenko, Dimitry, Go, Mary Ann T., Williams, Marna, Polson, Andrew G., Poon, Kirsten Achilles, Prabhu, Saileta
Publicado 2019

ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1

por Williams, Simon-Peter, Ogasawara, Annie, Tinianow, Jeff N., Flores, Judith E., Kan, David, Lau, Jeffrey, Go, MaryAnn, Vanderbilt, Alexander N., Gill, Herman S., Miao, Li, Goldsmith, Joshua, Rubinfeld, Bonnee, Mao, Weiguang, Firestein, Ron, Yu, Shang-Fan, Marik, Jan, Terwisscha van Scheltinga, Anton G.T.
Publicado 2016

Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

por Fourie-O’Donohue, Aimee, Chu, Phillip Y., dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C., Sawyer, William S., Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H., Sadowsky, Jack, Dragovich, Peter S., Liu, Yichin, Kozak, Katherine R.
Publicado 2020

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

por Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T., Pillow, Thomas H., Phillips, Gail D., Rowntree, Rebecca K, Boswell, C. Andrew, Kozak, Katherine R., Polson, Andrew G., Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S., Agard, Nicholas J.
Publicado 2020

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

por Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.
Publicado 2022

A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

por Zacharias, Neelie, Podust, Vladimir N., Kajihara, Kimberly K., Leipold, Douglas, Del Rosario, Geoffrey, Thayer, Desiree, Dong, Emily, Paluch, Maciej, Fischer, David, Zheng, Kai, Lei, Corinna, He, Jintang, Ng, Carl, Su, Dian, Liu, Luna, Masih, Shabkhaiz, Sawyer, William, Tinianow, Jeff, Marik, Jan, Yip, Victor, Li, Guangmin, Chuh, Josefa, Morisaki, J. Hiroshi, Park, Summer, Zheng, Bing, Hernandez-Barry, Hilda, Loyet, Kelly M., Xu, Min, Kozak, Katherine R., Phillips, Gail Lewis, Shen, Ben-Quan, Wu, Cong, Xu, Keyang, Yu, Shang-Fan, Kamath, Amrita, Rowntree, Rebecca K., Reilly, Dorothea, Pillow, Thomas, Polson, Andrew, Schellenberger, Volker, Hazenbos, Wouter L. W., Sadowsky, Jack
Publicado 2022