The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis

por Wang, Tian-Xiang, Liang, Jun-Yun, Zhang, Cheng, Xiong, Yue, Guan, Kun-Liang, Yuan, Hai-Xin
Publicado 2019

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

por Yuan, Hai-Xin, Wang, Zhen, Yu, Fa-Xing, Li, Fulong, Russell, Ryan C., Jewell, Jenna L., Guan, Kun-Liang
Publicado 2015

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation

por Han, Xiao-Ran, Zha, Zhengyu, Yuan, Hai-Xin, Feng, Xu, Xia, Yu-Kun, Lei, Qun-Ying, Guan, Kun-Liang, Xiong, Yue
Publicado 2016

Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis

por Li, Xiaoya, Zhong, Shaoping, Sun, Yifan, Huang, Xinmei, Li, Yue, Wang, Lihong, Wu, Yueyue, Yang, Min, Yuan, Hai-Xin, Liu, Jun, Zang, Shufei
Publicado 2022

Structural insights into TSC complex assembly and GAP activity on Rheb

por Yang, Huirong, Yu, Zishuo, Chen, Xizi, Li, Jiabei, Li, Ningning, Cheng, Jiaxuan, Gao, Ning, Yuan, Hai-Xin, Ye, Dan, Guan, Kun-Liang, Xu, Yanhui
Publicado 2021

CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML

por Liu, Peng, Liu, Jin-Pin, Sun, Si-Jia, Gao, Yun, Ai, Yingjie, Chen, Xiufei, Sun, Yiping, Zhou, Mengyu, Liu, Yun, Xiong, Yue, Yuan, Hai-Xin
Publicado 2021

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis

por Wang, Tian-Xiang, Duan, Kun-Long, Huang, Zi-Xuan, Xue, Zi-An, Liang, Jun-Yun, Dang, Yongjun, Zhang, Ao, Xiong, Yue, Ding, Chunyong, Guan, Kun-Liang, Yuan, Hai-Xin
Publicado 2022

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

por Liu, Meng-Xi, Jin, Lei, Sun, Si-Jia, Liu, Peng, Feng, Xu, Cheng, Zhou-Li, Liu, Wei-Ren, Guan, Kun-Liang, Shi, Ying-Hong, Yuan, Hai-Xin, Xiong, Yue
Publicado 2018

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

por Bao, Ruoxuan, Meng, Yongmei, Zhang, Haibo, Yang, Chen, Li, Wei, Zhang, Cheng, Zhang, Jinye, Sun, Renqiang, Li, Zengxia, Jiang, Wei, Zhang, Chensong, Zhang, Changsheng, Yuan, Hai-Xin, Dang, Yongjun
Publicado 2021

Whole exome sequencing identifies a KCNJ12 mutation as a cause of familial dilated cardiomyopathy

por Yuan, Hai-Xin, Yan, Kai, Hou, Dong-Yan, Zhang, Zhi-Yong, Wang, Hua, Wang, Xin, Zhang, Juan, Xu, Xiao-Rong, Liang, Yan-Hong, Zhao, Wen-Shu, Xu, Lin, Zhang, Lin
Publicado 2017

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

por Jewell, Jenna L, Fu, Vivian, Hong, Audrey W, Yu, Fa-Xing, Meng, Delong, Melick, Chase H, Wang, Huanyu, Lam, Wai-Ling Macrina, Yuan, Hai-Xin, Taylor, Susan S, Guan, Kun-Liang
Publicado 2019

Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance

por Liu, Peng, Sun, Si-Jia, Ai, Ying-Jie, Feng, Xu, Zheng, Yi-Min, Gao, Yun, Zhang, Jin-Ye, Zhang, Lei, Sun, Yi-Ping, Xiong, Yue, Lin, Miao, Yuan, Hai-Xin
Publicado 2022

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

por Li, Fu-Long, Liu, Jin-Ping, Bao, Ruo-Xuan, Yan, GuoQuan, Feng, Xu, Xu, Yan-Ping, Sun, Yi-Ping, Yan, Weili, Ling, Zhi-Qiang, Xiong, Yue, Guan, Kun-Liang, Yuan, Hai-Xin
Publicado 2018