Frontotemporal dementia‐linked P112H mutation of TDP‐43 induces protein structural change and impairs its RNA binding function

por Agrawal, Sashank, Jain, Monika, Yang, Wei‐Zen, Yuan, Hanna S.
Publicado 2020

Tudor staphylococcal nuclease is a structure-specific ribonuclease that degrades RNA at unstructured regions during microRNA decay

por Li, Chia-Lung, Yang, Wei-Zen, Shi, Zhonghao, Yuan, Hanna S.
Publicado 2018

Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing

por Li, Chia-Lung, Yang, Wei-Zen, Chen, Yi-Ping, Yuan, Hanna S.
Publicado 2008

Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer

por Lin, Jason L. J., Wu, Chyuan-Chuan, Yang, Wei-Zen, Yuan, Hanna S.
Publicado 2016

How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T–product complexes

por Hsiao, Yu-Yuan, Duh, Yulander, Chen, Yi-Ping, Wang, Yi-Ting, Yuan, Hanna S.
Publicado 2012

Structure and function of TatD exonuclease in DNA repair

por Chen, Yi-Chen, Li, Chia-Lung, Hsiao, Yu-Yuan, Duh, Yulander, Yuan, Hanna S.
Publicado 2014

Structural insights into nanoRNA degradation by human Rexo2

por Chu, Lee-Ya, Agrawal, Sashank, Chen, Yi-Ping, Yang, Wei-Zen, Yuan, Hanna S.
Publicado 2019

A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication

por Wu, Chyuan-Chuan, Lin, Jason L J, Yang-Yen, Hsin-Fang, Yuan, Hanna S
Publicado 2019

Efficient Strategy to Design Protease Inhibitors: Application to Enterovirus 71 2A Protease

por Chen, Ting, Grauffel, Cédric, Yang, Wei-Zen, Chen, Yi-Ping, Yuan, Hanna S., Lim, Carmay
Publicado 2022

Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases

por Wang, Yi-Ting, Yang, Wei-Jen, Li, Chia-Lung, Doudeva, Lyudmila G., Yuan, Hanna S.
Publicado 2007

Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation

por Lin, Chia Liang, Wang, Yi-Ting, Yang, Wei-Zen, Hsiao, Yu-Yuan, Yuan, Hanna S.
Publicado 2012

Structural Insights Into DNA Repair by RNase T—An Exonuclease Processing 3′ End of Structured DNA in Repair Pathways

por Hsiao, Yu-Yuan, Fang, Woei-Horng, Lee, Chia-Chia, Chen, Yi-Ping, Yuan, Hanna S.
Publicado 2014

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

por Kuo, Pan-Hsien, Chiang, Chien-Hao, Wang, Yi-Ting, Doudeva, Lyudmila G., Yuan, Hanna S.
Publicado 2014

RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation

por Agrawal, Sashank, Kuo, Pan-Hsien, Chu, Lee-Ya, Golzarroshan, Bagher, Jain, Monika, Yuan, Hanna S.
Publicado 2019

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

por Kuo, Pan-Hsien, Doudeva, Lyudmila G., Wang, Yi-Ting, Shen, Che-Kun James, Yuan, Hanna S.
Publicado 2009

Structural insights into RNA unwinding and degradation by RNase R

por Chu, Lee-Ya, Hsieh, Tung-Ju, Golzarroshan, Bagher, Chen, Yi-Ping, Agrawal, Sashank, Yuan, Hanna S.
Publicado 2017

Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B

por Lin, Chien-Chu, Chen, Yi-Ping, Yang, Wei-Zen, Shen, James C K, Yuan, Hanna S
Publicado 2020

Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and Remdesivir

por Chen, Ting, Fei, Cheng-Yin, Chen, Yi-Ping, Sargsyan, Karen, Chang, Chun-Ping, Yuan, Hanna S., Lim, Carmay
Publicado 2021

Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay

por Jain, Monika, Golzarroshan, Bagher, Lin, Chia‐Liang, Agrawal, Sashank, Tang, Wei‐Hsuan, Wu, Chiu‐Ju, Yuan, Hanna S.
Publicado 2022

Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities

por Golzarroshan, Bagher, Lin, Chia-Liang, Li, Chia-Lung, Yang, Wei-Zen, Chu, Lee-Ya, Agrawal, Sashank, Yuan, Hanna S
Publicado 2018