Structure, catalysis, chitin transport, and selective inhibition of chitin synthase

por Chen, Dan-Dan, Wang, Zhao-Bin, Wang, Le-Xuan, Zhao, Peng, Yun, Cai-Hong, Bai, Lin
Publicado 2023

Structural basis of mutant-selectivity and drug-resistance related to CO-1686

por Yan, Xiao-E, Zhu, Su-Jie, Liang, Ling, Zhao, Peng, Choi, Hwan Geun, Yun, Cai-Hong
Publicado 2017

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

por Sun, Fa-Hui, Zhao, Peng, Zhang, Nan, Kong, Lu-Lu, Wong, Catherine C. L., Yun, Cai-Hong
Publicado 2021

Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase

por Chen, Ji-Yun, Liu, Liang, Cao, Chun-Ling, Li, Mei-Jun, Tan, Kemin, Yang, Xiaohan, Yun, Cai-Hong
Publicado 2016

Acetylation of 53BP1 dictates the DNA double strand break repair pathway

por Guo, Xiang, Bai, Yongtai, Zhao, Meimei, Zhou, Mei, Shen, Qinjian, Yun, Cai-Hong, Zhang, Hongquan, Zhu, Wei-Guo, Wang, Jiadong
Publicado 2018

Structural insights into drug development strategy targeting EGFR T790M/C797S

por Zhu, Su-Jie, Zhao, Peng, Yang, Jiao, Ma, Rui, Yan, Xiao-E, Yang, Sheng-Yong, Yang, Jing-Wen, Yun, Cai-Hong
Publicado 2018

Structure of a fungal 1,3-β-glucan synthase

por Zhao, Chao-Ran, You, Zi-Long, Chen, Dan-Dan, Hang, Jing, Wang, Zhao-Bin, Ji, Meng, Wang, Le-Xuan, Zhao, Peng, Qiao, Jie, Yun, Cai-Hong, Bai, Lin
Publicado 2023

Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode

por Hu, Chen, Wang, Aoli, Wu, Hong, Qi, Ziping, Li, Xixiang, Yan, Xiao-E, Chen, Cheng, Yu, Kailin, Zou, Fengming, Wang, Wenchao, Wang, Wei, Wu, Jiaxin, Liu, Juan, Wang, Beilei, Wang, Li, Ren, Tao, Zhang, Shanchun, Yun, Cai-Hong, Liu, Jing, Liu, Qingsong
Publicado 2017

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

por Wang, Aoli, Yan, Xiao-E, Wu, Hong, Wang, Wenchao, Hu, Chen, Chen, Cheng, Zhao, Zheng, Zhao, Peng, Li, Xixiang, Wang, Li, Wang, Beilei, Ye, Zi, Wang, Jinhua, Wang, Chu, Zhang, Wei, Gray, Nathanael S., Weisberg, Ellen L., Chen, Liang, Liu, Jing, Yun, Cai-Hong, Liu, Qingsong
Publicado 2016

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

por Wu, Hong, Wang, Aoli, Zhang, Wei, Wang, Beilei, Chen, Cheng, Wang, Wenchao, Hu, Chen, Ye, Zi, Zhao, Zheng, Wang, Li, Li, Xixiang, Yu, Kailin, Liu, Juan, Wu, Jiaxin, Yan, Xiao-E, Zhao, Peng, Wang, Jinhua, Wang, Chu, Weisberg, Ellen L., Gray, Nathanael S., Yun, Cai-Hong, Liu, Jing, Chen, Liang, Liu, Qingsong
Publicado 2015

Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)

por Liu, Feiyang, Wang, Beilei, Wang, Qiang, Qi, Ziping, Chen, Cheng, Kong, Lu-Lu, Chen, Ji-Yun, Liu, Xiaochuan, Wang, Aoli, Hu, Chen, Wang, Wenchao, Wang, Huiping, Wu, Fan, Ruan, Yanjie, Qi, Shuang, Liu, Juan, Zou, Fengming, Hu, Zhenquan, Wang, Wei, Wang, Li, Zhang, Shanchun, Yun, Cai-Hong, Zhai, Zhimin, Liu, Jing, Liu, Qingsong
Publicado 2016

Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors

por Jia, Yong, Yun, Cai-Hong, Park, Eunyoung, Ercan, Dalia, Manuia, Mari, Juarez, Jose, Xu, Chunxiao, Rhee, Kevin, Chen, Ting, Zhang, Haikuo, Palakurthi, Sangeetha, Jang, Jaebong, Lelais, Gerald, DiDonato, Michael, Bursulaya, Badry, Michellys, Pierre-Yves, Epple, Robert, Marsilje, Thomas H., McNeill, Matthew, Lu, Wenshuo, Harris, Jennifer, Bender, Steven, Wong, Kwok-Kin, Jänne, Pasi A., Eck, Michael J.
Publicado 2016

A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC

por Lu, Yue, Fan, Zhenzhen, Zhu, Su‐Jie, Huang, Xiaoxing, Zhuang, Zhongji, Li, Yunzhan, Deng, Zhou, Gao, Lei, Hong, Xuehui, Zhang, Ting, Li, Li, Sun, Xihuan, Huang, Wei, Zhang, Jingfang, Liu, Yan, Zhang, Baoding, Jiang, Jie, Gui, Fu, Wang, Zheng, Li, Qiyuan, Song, Siyang, Huang, Xin, Wu, Qiao, Chen, Lanfen, Zhou, Dawang, Zhang, Jianming, Yun, Cai‐Hong, Chen, Liang, Deng, Xianming
Publicado 2021