IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

por Eto, Danelle, Lao, Christopher, DiToro, Daniel, Barnett, Burton, Escobar, Tania C., Kageyama, Robin, Yusuf, Isharat, Crotty, Shane
Publicado 2011

Germinal Center B Cell Depletion Diminishes CD4(+) Follicular T Helper Cells in Autoimmune Mice

por Yusuf, Isharat, Stern, Jessica, McCaughtry, Tom M., Gallagher, Sandra, Sun, Hong, Gao, Changshou, Tedder, Thomas, Carlesso, Gianluca, Carter, Laura, Herbst, Ronald, Wang, Yue
Publicado 2014

CLRM-15 TRIAL IN PROGRESS: A PHASE 1B/2 STUDY OF GB5121, A NOVEL, HIGHLY SELECTIVE, POTENT, AND CNS-PENETRANT INHIBITOR OF BRUTON’S TYROSINE KINASE (BTKI) FOR RELAPSED/REFRACTORY P...

por Soussain, Carole, Grommes, Christian, Issa, Samar, Ward, Renee, Peterson, Caryn, Cravets, Matt, Mathias, Anita, Sosa, Judith, Kirby, Brian, Ding, Zhaoqing, Yusuf, Isharat, Rose, Mark, Steinberg, Marcos, Tun, Han W
Publicado 2022

Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination

por Evonuk, Kirsten Scarlett, Wang, Sen, Mattie, Josh, Cracchiolo, C. J., Mager, Reine, Ferenčić, Željko, Sprague, Ethan, Carrier, Brandon, Schofield, Kai, Martinez, Evelyn, Stewart, Zachary, Petrosino, Tara, Johnson, Gregory Andrew, Yusuf, Isharat, Plaisted, Warren, Naiman, Zachary, Delp, Timothy, Carter, Laura, Marušić, Suzana
Publicado 2023