Cholesterol metabolism pathways – are the intermediates more important than the products?

por Wang, Yuqin, Yutuc, Eylan, Griffiths, William J.
Publicado 2021

Developing an Enzyme-Assisted Derivatization Method for Analysis of C(27) Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry

por Abdel-Khalik, Jonas, Crick, Peter J., Yutuc, Eylan, Wang, Yuqin, Griffiths, William J.
Publicado 2019

Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry

por Dickson, Alison L., Yutuc, Eylan, Thornton, Catherine A., Wang, Yuqin, Griffiths, William J.
Publicado 2022

Current trends in oxysterol research

por Griffiths, William J., Abdel-Khalik, Jonas, Hearn, Thomas, Yutuc, Eylan, Morgan, Alwena H., Wang, Yuqin
Publicado 2016

HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta

por Dickson, Alison, Yutuc, Eylan, Thornton, Catherine A., Dunford, James E., Oppermann, Udo, Wang, Yuqin, Griffiths, William J.
Publicado 2023

Cholesterolomics: An update

por Griffiths, William J., Abdel-Khalik, Jonas, Yutuc, Eylan, Morgan, Alwena H., Gilmore, Ian, Hearn, Thomas, Wang, Yuqin
Publicado 2017

Charge-tagging liquid chromatography–mass spectrometry methodology targeting oxysterol diastereoisomers

por Griffiths, William J., Hearn, Thomas, Crick, Peter J., Abdel-Khalik, Jonas, Dickson, Alison, Yutuc, Eylan, Wang, Yuqin
Publicado 2017

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

por Griffiths, William J., Abdel-Khalik, Jonas, Yutuc, Eylan, Roman, Gustavo, Warner, Margaret, Gustafsson, Jan-Åke, Wang, Yuqin
Publicado 2019

Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse

por Crick, Peter J., Yutuc, Eylan, Abdel-Khalik, Jonas, Saeed, Ahmed, Betsholtz, Christer, Genove, Guillem, Björkhem, Ingemar, Wang, Yuqin, Griffiths, William J.
Publicado 2019

Mining for Oxysterols in Cyp7b1(−/−) Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

por Meljon, Anna, Crick, Peter J., Yutuc, Eylan, Yau, Joyce L., Seckl, Jonathan R., Theofilopoulos, Spyridon, Arenas, Ernest, Wang, Yuqin, Griffiths, William J.
Publicado 2019

Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle

por Hudson, Nicholas J., Reverter, Antonio, Griffiths, William J., Yutuc, Eylan, Wang, Yuqin, Jeanes, Angela, McWilliam, Sean, Pethick, David W., Greenwood, Paul L.
Publicado 2020

Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma

por Abdel-Khalik, Jonas, Crick, Peter J., Yutuc, Eylan, DeBarber, Andrea E., Duell, P. Barton, Steiner, Robert D., Laina, Ioanna, Wang, Yuqin, Griffiths, William J.
Publicado 2018

Defective cholesterol metabolism in amyotrophic lateral sclerosis

por Abdel-Khalik, Jonas, Yutuc, Eylan, Crick, Peter J., Gustafsson, Jan-Åke, Warner, Margaret, Roman, Gustavo, Talbot, Kevin, Gray, Elizabeth, Griffiths, William J., Turner, Martin R., Wang, Yuqin
Publicado 2017

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

por Yutuc, Eylan, Angelini, Roberto, Baumert, Mark, Mast, Natalia, Pikuleva, Irina, Newton, Jillian, Clench, Malcolm R., Skibinski, David O. F., Howell, Owain W., Wang, Yuqin, Griffiths, William J.
Publicado 2020

Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma

por Griffiths, William J., Crick, Peter J., Meljon, Anna, Theofilopoulos, Spyridon, Abdel-Khalik, Jonas, Yutuc, Eylan, Parker, Josie E., Kelly, Diane E., Kelly, Steven L., Arenas, Ernest, Wang, Yuqin
Publicado 2019

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

por Theofilopoulos, Spyridon, Abreu de Oliveira, Willy Antoni, Yang, Shanzheng, Yutuc, Eylan, Saeed, Ahmed, Abdel-Khalik, Jonas, Ullgren, Abbe, Cedazo-Minguez, Angel, Björkhem, Ingemar, Wang, Yuqin, Griffiths, William J., Arenas, Ernest
Publicado 2019

Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation

por Griffiths, William J., Gilmore, Ian, Yutuc, Eylan, Abdel-Khalik, Jonas, Crick, Peter J., Hearn, Thomas, Dickson, Alison, Bigger, Brian W., Wu, Teresa Hoi-Yee, Goenka, Anu, Ghosh, Arunabha, Jones, Simon A., Wang, Yuqin
Publicado 2018

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders()()

por Griffiths, William J., Yutuc, Eylan, Abdel-Khalik, Jonas, Crick, Peter J., Hearn, Thomas, Dickson, Alison, Bigger, Brian W., Hoi-Yee Wu, Teresa, Goenka, Anu, Ghosh, Arunabha, Jones, Simon A., Covey, Douglas F., Ory, Daniel S., Wang, Yuqin
Publicado 2019

Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis

por Höflinger, Philip, Hauser, Stefan, Yutuc, Eylan, Hengel, Holger, Griffiths, Lauren, Radelfahr, Florentine, Howell, Owain W., Wang, Yuqin, Connor, Sonja L., Duell, P. Barton, DeBarber, Andrea E., Martus, Peter, Lütjohann, Dieter, Griffiths, William J., Schöls, Ludger
Publicado 2021

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

por Griffiths, William J., Abdel-Khalik, Jonas, Moore, Sarah F., Wijeyekoon, Ruwani S., Crick, Peter J., Yutuc, Eylan, Farrell, Krista, Breen, David P., Williams-Gray, Caroline H., Theofilopoulos, Spyridon, Arenas, Ernest, Trupp, Miles, Barker, Roger A., Wang, Yuqin
Publicado 2021