PBPK modeling and simulation in drug research and development

por Zhuang, Xiaomei, Lu, Chuang
Publicado 2016

2,5-Bis(4-methyl­phen­yl)-4-oxopenta­noic acid

por Wang, Jun, Zhuang, Xiaomei, Hou, Yong
Publicado 2010

Poly[[[μ(3)-N′-(carboxymethyl)ethylene­di­amine-N,N,N′-triacetato]dysprosium(III)] trihydrate]

por Zhuang, Xiaomei, Long, Qingping, Wang, Jun
Publicado 2010

p73 expression is associated with cellular chemosensitivity in human non-small cell lung cancer cell lines

por LIU, KAISHAN, ZHUANG, XIAOMEI, MAI, ZHUOYING
Publicado 2013

Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells

por Wu, Man, Zhao, Guanren, Zhuang, Xiaomei, Zhang, Tianhong, Zhang, Ce, Zhang, Wenpeng, Zhang, Zhenqing
Publicado 2018

Comparable Intestinal and Hepatic First-Pass Effect of YL-IPA08 on the Bioavailability and Effective Brain Exposure, a Rapid Anti-PTSD and Anti-Depression Compound

por Gao, You, Yang, Chunmiao, Wang, Lingchao, Xiang, Yanan, Zhang, Wenpeng, Li, Yunfeng, Zhuang, Xiaomei
Publicado 2020

Recent advances of three-dimensional bioprinting technology in hepato-pancreato-biliary cancer models

por Zhuang, Xiaomei, Deng, Gang, Wu, Xiaoying, Xie, Juping, Li, Dong, Peng, Songlin, Tang, Di, Zhou, Guoying
Publicado 2023

Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline

por Ding, Yangming, Liu, Haiting, Wang, Furun, Fu, Lei, Zhu, Hui, Fu, Shuang, Wang, Ning, Zhuang, Xiaomei, Lu, Yu
Publicado 2023

A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox

por Zhang, Zhiwei, Fu, Shuang, Wang, Furun, Yang, Chunmiao, Wang, Lingchao, Yang, Meiyan, Zhang, Wenpeng, Zhong, Wu, Zhuang, Xiaomei
Publicado 2022

An exploration on retro-construction of plasma drug concentration-time curves from corresponding urine excretion data and single-point plasma concentrations using a simplified and...

por Li, Guanglu, Zhang, Wenpeng, Zhang, Meng, Xu, Jiamin, Zhu, Guanghua, Li, Jinglai, Luo, Huan, Zhuang, Xiaomei, Wang, Quanjun, Zhang, Tianhong
Publicado 2023

Alternation of Organ-Specific Exposure in LPS-Induced Pneumonia Mice after the Inhalation of Tetrandrine Is Governed by Metabolizing Enzyme Suppression and Lysosomal Trapping

por Wang, Furun, Jiang, Xue, Yang, Zengxu, Fu, Shuang, Yao, Shi, Wang, Lingchao, Lv, Yue, Zhang, Wenpeng, Ding, Rigao, Zhuang, Xiaomei
Publicado 2022

Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34)

por Wang, Dan, Du, Yimeng, Zhang, Wenpeng, Han, Xiaolu, Zhang, Hui, Wang, Zengming, Liu, Nan, Li, Meng, Gao, Xiang, Zhuang, Xiaomei, Gao, Jing, Zheng, Aiping
Publicado 2021

Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approac...

por He, Qingfeng, Bu, Fengjiao, Wang, Qizhen, Li, Min, Lin, Jiaying, Tang, Zhijia, Mak, Wen Yao, Zhuang, Xiaomei, Zhu, Xiao, Lin, Hai-Shu, Xiang, Xiaoqiang
Publicado 2022

High-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity

por Liu, Juan, Li, Ruihong, Zhang, Tingting, Xue, Rui, Li, Tingting, Li, Zheng, Zhuang, Xiaomei, Wang, Qi, Chen, Yu Ann, Dong, Jiahong, Zhang, Youzhi, Wang, Yunfang
Publicado 2022

Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease

por Peng, Axiang, Gao, Yuehong, Zhuang, Xiaomei, Lin, Yaoqi, He, Wencan, Wang, Yannan, Chen, Wenfan, Chen, Tingting, Huang, Xiaoqing, Yang, Renzhi, Huang, Yuanpeng, Xi, Shengyan, Zhang, Xian
Publicado 2019

Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations

por Li, Pengyun, Jia, Changkai, Fan, Zhiya, Hu, Xiaotong, Zhang, Wenjuan, Liu, Ke, Sun, Shiyang, Guo, Haoxin, Yang, Ning, Zhu, Maoxiang, Zhuang, Xiaomei, Xiao, Junhai, Zheng, Zhibing, Li, Song
Publicado 2023

Gut Microbiome-Targeted Modulations Regulate Metabolic Profiles and Alleviate Altitude-Related Cardiac Hypertrophy in Rats

por Hu, Yichen, Pan, Zhiyuan, Huang, Zongyu, Li, Yan, Han, Ni, Zhuang, Xiaomei, Peng, Hui, Gao, Quansheng, Wang, Qing, Yang Lee, B. J., Zhang, Heping, Yang, Ruifu, Bi, Yujing, Xu, Zhenjiang Zech
Publicado 2022

The Molecular Mechanisms of Resistance to IDH Inhibitors in Acute Myeloid Leukemia

por Zhuang, Xiaomei, Pei, Han Zhong, Li, Tianwen, Huang, Junbin, Guo, Yao, Zhao, Yuming, Yang, Ming, Zhang, Dengyang, Chang, Zhiguang, Zhang, Qi, Yu, Liuting, He, Chunxiao, Zhang, Liqing, Pan, Yihang, Chen, Chun, Chen, Yun
Publicado 2022

miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia

por Pei, Han Zhong, Peng, Zhiyong, Zhuang, Xiaomei, Wang, Xiaobo, Lu, Bo, Guo, Yao, Zhao, Yuming, Zhang, Dengyang, Xiao, Yunjun, Gao, Tianshun, Yu, Liuting, He, Chunxiao, Wu, Shunjie, Baek, Suk-Hwan, Zhao, Zhizhuang Joe, Xu, Xiaojun, Chen, Yun
Publicado 2023

Antiviral effects and tissue exposure of tetrandrine against SARS‐CoV‐2 infection and COVID‐19

por Liu, Jia, Wang, Furun, Wang, Xi, Fan, Shiyong, Li, Yufeng, Xu, Mingyue, Hu, Hengrui, Liu, Ke, Zheng, Bohong, Wang, Lingchao, Zhang, Huanyu, Li, Jiang, Li, Wei, Zhang, Wenpeng, Hu, Zhihong, Cao, Ruiyuan, Zhuang, Xiaomei, Wang, Manli, Zhong, Wu
Publicado 2023