Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic...

por Fling, Russell R., Zacharewski, Timothy R.
Publicado 2021

Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver

por Cholico, Giovan N., Nault, Rance, Zacharewski, Tim R.
Publicado 2022

Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin

por Nault, Rance, Fader, Kelly A., Bhattacharya, Sudin, Zacharewski, Tim R.
Publicado 2020

A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds

por Liu, Rongrui, Zacharewski, Tim R., Conolly, Rory B., Zhang, Qiang
Publicado 2022

Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorina...

por Fielden, M R, Chen, I, Chittim, B, Safe, S H, Zacharewski, T R
Publicado 1997

In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

por Dere, Edward, Boverhof, Darrell R, Burgoon, Lyle D, Zacharewski, Timothy R
Publicado 2006

Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells

por Dere, Edward, Lee, Andrea W, Burgoon, Lyle D, Zacharewski, Timothy R
Publicado 2011

Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver

por Dere, Edward, Lo, Raymond, Celius, Trine, Matthews, Jason, Zacharewski, Timothy R
Publicado 2011

Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity

por Jurgelewicz, Amanda, Nault, Rance, Harkema, Jack, Zacharewski, Timothy R., LaPres, John J.
Publicado 2023

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

por Fader, Kelly A., Nault, Rance, Doskey, Claire M., Fling, Russell R., Zacharewski, Timothy R.
Publicado 2019

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

por Fling, Russell R., Doskey, Claire M., Fader, Kelly A., Nault, Rance, Zacharewski, Tim R.
Publicado 2020

Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

por Fong, Cora J, Burgoon, Lyle D, Williams, Kurt J, Forgacs, Agnes L, Zacharewski, Timothy R
Publicado 2007

Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program

por Kwekel, Joshua C, Forgacs, Agnes L, Burgoon, Lyle D, Williams, Kurt J, Zacharewski, Timothy R
Publicado 2009

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

por Fader, Kelly A., Nault, Rance, Zhang, Chen, Kumagai, Kazuyoshi, Harkema, Jack R., Zacharewski, Timothy R.
Publicado 2017

Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice

por Dornbos, Peter, Jurgelewicz, Amanda, Fader, Kelly A., Williams, Kurt, Zacharewski, Timothy R., LaPres, John J.
Publicado 2019

Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation

por Cholico, Giovan N., Fling, Russell R., Zacharewski, Nicholas A., Fader, Kelly A., Nault, Rance, Zacharewski, Timothy R.
Publicado 2021

Protocols for the assurance of microarray data quality and process control

por Burgoon, L. D., Eckel-Passow, J. E., Gennings, C., Boverhof, D. R., Burt, J. W., Fong, C. J., Zacharewski, T. R.
Publicado 2005

Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT

por Kiyosawa, Naoki, Kwekel, Joshua C, Burgoon, Lyle D, Dere, Edward, Williams, Kurt J, Tashiro, Colleen, Chittim, Brock, Zacharewski, Timothy R
Publicado 2008

Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium

por Thompson, Chad M., Proctor, Deborah M., Haws, Laurie C., Hébert, Charles D., Grimes, Sheila D., Shertzer, Howard G., Kopec, Anna K., Hixon, J.Gregory, Zacharewski, Timothy R., Harris, Mark A.
Publicado 2011

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice

por Saini, Yogesh, Proper, Steven P., Dornbos, Peter, Greenwood, Krista K., Kopec, Anna K., Lynn, Scott G., Grier, Elizabeth, Burgoon, Lyle D., Zacharewski, Timothy R., Thomas, Russell S., Harkema, Jack R., LaPres, John J.
Publicado 2015