Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

por Flowers, Ebony M., Sudderth, Jessica, Zacharias, Lauren, Mernaugh, Glenda, Zent, Roy, DeBerardinis, Ralph J., Carroll, Thomas J.
Publicado 2018

Optimized protocol for stable isotope tracing and steady-state metabolomics in mouse HER2+ breast cancer brain metastasis

por Parida, Pravat Kumar, Marquez-Palencia, Mauricio, Kaushik, Akash K., Kim, Kangsan, Nair, Vidhya, Sudderth, Jessica, Vu, Hieu, Zacharias, Lauren, DeBerardinis, Ralph, Malladi, Srinivas
Publicado 2022

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

por Hao, Yi-Heng, Lafita-Navarro, M. Carmen, Zacharias, Lauren, Borenstein-Auerbach, Nofit, Kim, Min, Barnes, Spencer, Kim, Jiwoong, Shay, Jerry, DeBerardinis, Ralph J., Conacci-Sorrell, Maralice
Publicado 2019

SNAT7 regulates mTORC1 via macropinocytosis

por Meng, Delong, Yang, Qianmei, Jeong, Mi-Hyeon, Curukovic, Adna, Tiwary, Shweta, Melick, Chase H., Lama-Sherpa, Tshering D., Wang, Huanyu, Huerta-Rosario, Mariela, Urquhart, Greg, Zacharias, Lauren G., Lewis, Cheryl, DeBerardinis, Ralph J., Jewell, Jenna L.
Publicado 2022

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

por Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.
Publicado 2019

Using arterial–venous analysis to characterize cancer metabolic consumption in patients

por Xiong, Nanxiang, Gao, Xiaofei, Zhao, Hongyang, Cai, Feng, Zhang, Fang-cheng, Yuan, Ye, Liu, Weichao, He, Fangping, Zacharias, Lauren G., Lin, Hong, Vu, Hieu S., Xing, Chao, Yao, Dong-Xiao, Chen, Fei, Luo, Benyan, Sun, Wenzhi, DeBerardinis, Ralph J., Xu, Hao, Ge, Woo-ping
Publicado 2020

1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

por Kilgour, Marisa K., MacPherson, Sarah, Zacharias, Lauren G., Ellis, Abigail E., Sheldon, Ryan D., Liu, Elaine Y., Keyes, Sarah, Pauly, Brenna, Carleton, Gillian, Allard, Bertrand, Smazynski, Julian, Williams, Kelsey S., Watson, Peter H., Stagg, John, Nelson, Brad H., DeBerardinis, Ralph J., Jones, Russell G., Hamilton, Phineas T., Lum, Julian J.
Publicado 2021

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

por Ni, Min, Solmonson, Ashley, Pan, Chunxiao, Yang, Chendong, Li, Dan, Notzon, Ashley, Cai, Ling, Guevara, Gerardo, Zacharias, Lauren G., Faubert, Brandon, Vu, Hieu S., Jiang, Lei, Ko, Bookyung, Morales, Noriko Merida, Pei, Jimin, Vale, Gonçalo, Rakheja, Dinesh, Grishin, Nick V., McDonald, Jeffrey G., Gotway, Garrett K., McNutt, Markey C., Pascual, Juan M., DeBerardinis, Ralph J.
Publicado 2019

Compartmentalized metabolism supports midgestation mammalian development

por Solmonson, Ashley, Faubert, Brandon, Gu, Wen, Rao, Aparna, Cowdin, Mitzy A., Menendez-Montes, Ivan, Kelekar, Sherwin, Rogers, Thomas J., Pan, Chunxiao, Guevara, Gerardo, Tarangelo, Amy, Zacharias, Lauren G., Martin-Sandoval, Misty S., Do, Duyen, Pachnis, Panayotis, Dumesnil, Dennis, Mathews, Thomas P., Tasdogan, Alpaslan, Pham, An, Cai, Ling, Zhao, Zhiyu, Ni, Min, Cleaver, Ondine, Sadek, Hesham A., Morrison, Sean J., DeBerardinis, Ralph J.
Publicado 2022

In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

por Pachnis, Panayotis, Wu, Zheng, Faubert, Brandon, Tasdogan, Alpaslan, Gu, Wen, Shelton, Spencer, Solmonson, Ashley, Rao, Aparna D., Kaushik, Akash K., Rogers, Thomas J., Ubellacker, Jessalyn M., LaVigne, Collette A., Yang, Chendong, Ko, Bookyung, Ramesh, Vijayashree, Sudderth, Jessica, Zacharias, Lauren G., Martin-Sandoval, Misty S., Do, Duyen, Mathews, Thomas P., Zhao, Zhiyu, Mishra, Prashant, Morrison, Sean J., DeBerardinis, Ralph J.
Publicado 2022

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

por Kaushik, Akash K., Tarangelo, Amy, Boroughs, Lindsey K., Ragavan, Mukundan, Zhang, Yuanyuan, Wu, Cheng-Yang, Li, Xiangyi, Ahumada, Kristen, Chiang, Jui-Chung, Tcheuyap, Vanina T., Saatchi, Faeze, Do, Quyen N., Yong, Cissy, Rosales, Tracy, Stevens, Christina, Rao, Aparna D., Faubert, Brandon, Pachnis, Panayotis, Zacharias, Lauren G., Vu, Hieu, Cai, Feng, Mathews, Thomas P., Genovese, Giannicola, Slusher, Barbara S., Kapur, Payal, Sun, Xiankai, Merritt, Matthew, Brugarolas, James, DeBerardinis, Ralph J.
Publicado 2022

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

por Shi, Diana D., Savani, Milan R., Levitt, Michael M., Wang, Adam C., Endress, Jennifer E., Bird, Cylaina E., Buehler, Joseph, Stopka, Sylwia A., Regan, Michael S., Lin, Yu-Fen, Puliyappadamba, Vinesh T., Gao, Wenhua, Khanal, Januka, Evans, Laura, Lee, Joyce H., Guo, Lei, Xiao, Yi, Xu, Min, Huang, Bofu, Jennings, Rebecca B., Bonal, Dennis M., Martin-Sandoval, Misty S., Dang, Tammie, Gattie, Lauren C., Cameron, Amy B., Lee, Sungwoo, Asara, John M., Kornblum, Harley I., Mak, Tak W., Looper, Ryan E., Nguyen, Quang-De, Signoretti, Sabina, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Lehrman, Mark A., Zacharias, Lauren G., Mathews, Thomas P., Losman, Julie-Aurore, Richardson, Timothy E., Cahill, Daniel P., DeBerardinis, Ralph J., Ligon, Keith L., Xu, Lin, Ly, Peter, Agar, Nathalie Y.R., Abdullah, Kalil G., Harris, Isaac S., Kaelin, William G., McBrayer, Samuel K.
Publicado 2022