Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors

por Zain, Rula, Vihinen, Mauno
Publicado 2021

Targeted Oligonucleotides for Treating Neurodegenerative Tandem Repeat Diseases

por Zain, Rula, Smith, C. I. Edvard
Publicado 2019

Structural Insights into Human Adenovirus Type 4 Virus-Associated RNA I

por Bergquist, Helen, Inturi, Raviteja, Zain, Rula, Punga, Tanel
Publicado 2022

Editorial: New Insights on Bruton’s Tyrosine Kinase Inhibitors

por Smith, C. I. Edvard, Brown, Jennifer R., Zain, Rula
Publicado 2021

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

por Estupiñán, H. Yesid, Berglöf, Anna, Zain, Rula, Smith, C. I. Edvard
Publicado 2021

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

por Hande, Madhuri, Saher, Osama, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Lönnberg, Tuomas
Publicado 2019

Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID‐19 in chronic lymphocytic leukaemia?

por Smith, Carl Inge Edvard, Zain, Rula, Österborg, Anders, Palma, Marzia, Buggert, Marcus, Bergman, Peter, Bryceson, Yenan
Publicado 2022

Oligonucleotide Binding to Non-B-DNA in MYC

por Umek, Tea, Sollander, Karin, Bergquist, Helen, Wengel, Jesper, Lundin, Karin E., Smith, C.I. Edvard, Zain, Rula
Publicado 2019

Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers...

por Rastokina, Anastasia, Cebrián, Jorge, Mozafari, Negin, Mandel, Nicholas H, Smith, C I Edvard, Lopes, Massimo, Zain, Rula, Mirkin, Sergei M
Publicado 2023

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

por Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra
Publicado 2019

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

por Hartono, Yossa Dwi, Pabon-Martinez, Y. Vladimir, Uyar, Arzu, Wengel, Jesper, Lundin, Karin E., Zain, Rula, Smith, C. I. Edvard, Nilsson, Lennart, Villa, Alessandra
Publicado 2017

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

por Saher, Osama, Lehto, Taavi, Gissberg, Olof, Gupta, Dhanu, Gustafsson, Oskar, Andaloussi, Samir EL, Darbre, Tamis, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula
Publicado 2019

Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)(n) Repeats by PNA or LNA Targeting

por Bergquist, Helen, Rocha, Cristina S. J., Álvarez-Asencio, Rubén, Nguyen, Chi-Hung, Rutland, Mark. W., Smith, C. I. Edvard, Good, Liam, Nielsen, Peter E., Zain, Rula
Publicado 2016

Ibrutinib Has Time-dependent On- and Off-target Effects on Plasma Biomarkers and Immune Cells in Chronic Lymphocytic Leukemia

por Mulder, Tom A., Peña-Pérez, Lucía, Berglöf, Anna, Meinke, Stephan, Estupiñán, H. Yesid, Heimersson, Kia, Zain, Rula, Månsson, Robert, Smith, C. I. Edvard, Palma, Marzia
Publicado 2021

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

por Zaghloul, Eman M., Gissberg, Olof, Moreno, Pedro M.D., Siggens, Lee, Hällbrink, Mattias, Jørgensen, Anna S., Ekwall, Karl, Zain, Rula, Wengel, Jesper, Lundin, Karin E., Smith, C.I. Edvard
Publicado 2017

BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib

por Estupiñán, H. Yesid, Wang, Qing, Berglöf, Anna, Schaafsma, Gerard C. P., Shi, Yuye, Zhou, Litao, Mohammad, Dara K., Yu, Liang, Vihinen, Mauno, Zain, Rula, Smith, C. I. Edvard
Publicado 2021

Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

por Umek, Tea, Olsson, Thomas, Gissberg, Olof, Saher, Osama, Zaghloul, Eman M., Lundin, Karin E., Wengel, Jesper, Hanse, Eric, Zetterberg, Henrik, Vizlin-Hodzic, Dzeneta, Smith, C. I. Edvard, Zain, Rula
Publicado 2021

2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

por Honcharenko, Dmytro, Rocha, Cristina S.J., Lundin, Karin E., Maity, Jyotirmoy, Milton, Stefan, Tedebark, Ulf, Murtola, Merita, Honcharenko, Malgorzata, Slaitas, Andis, Smith, C.I. Edvard, Zain, Rula, Strömberg, Roger
Publicado 2022

Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides

por Saher, Osama, Zaghloul, Eman M., Umek, Tea, Hagey, Daniel W., Mozafari, Negin, Danielsen, Mathias B., Gouda, Alaa S., Lundin, Karin E., Jørgensen, Per T., Wengel, Jesper, Smith, C.I. Edvard, Zain, Rula
Publicado 2023

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

por Daralnakhla, Haneen, Saher, Osama, Zamolo, Susanna, Bazaz, Safa, P. Bost, Jeremy, Heitz, Marc, Lundin, Karin E., EL Andaloussi, Samir, Darbre, Tamis, Reymond, Jean-Louis, Zain, Rula, Smith, C. I. Edvard
Publicado 2021