Pharmacogenetics – Challenges and Opportunities Ahead

por Zanger, Ulrich M.
Publicado 2010

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the “Missing Heritability” Problem

por Klein, Kathrin, Zanger, Ulrich M.
Publicado 2013

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

por Zanger, Ulrich M., Klein, Kathrin
Publicado 2013

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions – Focus on Interactions with Cytochromes P450

por Ryu, Chang S., Klein, Kathrin, Zanger, Ulrich M.
Publicado 2017

MIRNA-DISTILLER: A Stand-Alone Application to Compile microRNA Data from Databases

por Rieger, Jessica K., Bodan, Denis A., Zanger, Ulrich M.
Publicado 2011

Molecular Interactions between NAFLD and Xenobiotic Metabolism

por Naik, Adviti, Belič, Aleš, Zanger, Ulrich M., Rozman, Damjana
Publicado 2013

Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

por Heintze, Tamara, Klein, Kathrin, Hofmann, Ute, Zanger, Ulrich M.
Publicado 2021

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver

por Klein, Kathrin, Winter, Stefan, Turpeinen, Miia, Schwab, Matthias, Zanger, Ulrich M.
Publicado 2010

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

por Riedmaier, Stephan, Klein, Kathrin, Winter, Stefan, Hofmann, Ute, Schwab, Matthias, Zanger, Ulrich M.
Publicado 2011

Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained

por Kungulovski, Goran, Nunna, Suneetha, Thomas, Maria, Zanger, Ulrich M, Reinhardt, Richard, Jeltsch, Albert
Publicado 2015

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

por Thomas, Maria, Bayha, Christine, Klein, Kathrin, Müller, Simon, Weiss, Thomas S., Schwab, Matthias, Zanger, Ulrich M.
Publicado 2015

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods

por Feuer, Ronny, Vlaic, Sebastian, Arlt, Janine, Sawodny, Oliver, Dahmen, Uta, Zanger, Ulrich M., Thomas, Maria
Publicado 2015

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

por Thomas, Maria, Winter, Stefan, Klumpp, Britta, Turpeinen, Miia, Klein, Kathrin, Schwab, Matthias, Zanger, Ulrich M.
Publicado 2015

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

por Heintze, Tamara, Wilhelm, Denise, Schmidlin, Thierry, Hofmann, Ute, Zanger, Ulrich M., Schwab, Matthias, Klein, Kathrin
Publicado 2021

Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease

por Zhang, Yijing, Klein, Kathrin, Sugathan, Aarathi, Nassery, Najlla, Dombkowski, Alan, Zanger, Ulrich M., Waxman, David J.
Publicado 2011

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

por Pandey, Amit V., Henderson, Colin J., Ishii, Yuji, Kranendonk, Michel, Backes, Wayne L., Zanger, Ulrich M.
Publicado 2017

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

por Nies, Anne T, Niemi, Mikko, Burk, Oliver, Winter, Stefan, Zanger, Ulrich M, Stieger, Bruno, Schwab, Matthias, Schaeffeler, Elke
Publicado 2013

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

por Zhang, J. E., Klein, Kathrin, Jorgensen, Andrea L., Francis, Ben, Alfirevic, Ana, Bourgeois, Stephane, Deloukas, Panagiotis, Zanger, Ulrich M., Pirmohamed, Munir
Publicado 2017

A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

por Klein, Kathrin, Tremmel, Roman, Winter, Stefan, Fehr, Sarah, Battke, Florian, Scheurenbrand, Tim, Schaeffeler, Elke, Biskup, Saskia, Schwab, Matthias, Zanger, Ulrich M.
Publicado 2019

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages

por Rex, Julia, Albrecht, Ute, Ehlting, Christian, Thomas, Maria, Zanger, Ulrich M., Sawodny, Oliver, Häussinger, Dieter, Ederer, Michael, Feuer, Ronny, Bode, Johannes G.
Publicado 2016