Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization

por Pastorio, Chiara, Noettger, Sabrina, Nchioua, Rayhane, Zech, Fabian, Sparrer, Konstantin M.J., Kirchhoff, Frank
Publicado 2023

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

por Jung, Christoph, Kmiec, Dorota, Koepke, Lennart, Zech, Fabian, Jacob, Timo, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2022

Near-Native Visualization of SARS-CoV-2 Induced Membrane Remodeling and Virion Morphogenesis

por Bergner, Tim, Zech, Fabian, Hirschenberger, Maximilian, Stenger, Steffen, Sparrer, Konstantin M. J., Kirchhoff, Frank, Read, Clarissa
Publicado 2022

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

por Pastorio, Chiara, Zech, Fabian, Noettger, Sabrina, Jung, Christoph, Jacob, Timo, Sanderson, Theo, Sparrer, Konstantin M.J., Kirchhoff, Frank
Publicado 2022

Clinical, Imaging, and Histopathological Features of Pulmonary Sequelae after Mild COVID-19

por Gagiannis, Daniel, Hackenbroch, Carsten, Bloch, Wilhelm, Zech, Fabian, Kirchhoff, Frank, Djudjaj, Sonja, von Stillfried, Saskia, Bülow, Roman, Boor, Peter, Steinestel, Konrad
Publicado 2023

Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Boosts Neutralizing Activity Against Seasonal Human Coronaviruses

por Lawrenz, Jan, Xie, Qinya, Zech, Fabian, Weil, Tatjana, Seidel, Alina, Krnavek, Daniela, van der Hoek, Lia, Münch, Jan, Müller, Janis A, Kirchhoff, Frank
Publicado 2022

Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes

por Nchioua, Rayhane, Diofano, Federica, Noettger, Sabrina, von Maltitz, Pascal, Stenger, Steffen, Zech, Fabian, Münch, Jan, Sparrer, Konstantin M. J., Just, Steffen, Kirchhoff, Frank
Publicado 2022

Peptide Bispecifics Inhibiting HIV-1 Infection by an Orthogonal Chemical and Supramolecular Strategy

por Schauenburg, Dominik, Zech, Fabian, Heck, Astrid Johanna, von Maltitz, Pascal, Harms, Mirja, Führer, Siska, Alleva, Nico, Münch, Jan, Kuan, Seah Ling, Kirchhoff, Frank, Weil, Tanja
Publicado 2023

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

por Wang, Qingxing, Noettger, Sabrina, Xie, Qinya, Pastorio, Chiara, Seidel, Alina, Müller, Janis A., Jung, Christoph, Jacob, Timo, Sparrer, Konstantin M. J., Zech, Fabian, Kirchhoff, Frank
Publicado 2023

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

por Zech, Fabian, Weber, Stefanie, Dietenberger, Hanna, Zhang, Linyun, Noettger, Sabrina, Volcic, Meta, Bergner, Tim, Read, Clarissa, Sparrer, Konstantin M. J., Barth, Thomas F. E., Kirchhoff, Frank
Publicado 2023

SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells

por Nchioua, Rayhane, Schundner, Annika, Kmiec, Dorota, Prelli Bozzo, Caterina, Zech, Fabian, Koepke, Lennart, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Frick, Manfred, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2022

Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2

por Xie, Qinya, Bozzo, Caterina Prelli, Eiben, Laura, Noettger, Sabrina, Kmiec, Dorota, Nchioua, Rayhane, Niemeyer, Daniela, Volcic, Meta, Lee, Jung-Hyun, Zech, Fabian, Sparrer, Konstantin M.J., Drosten, Christian, Kirchhoff, Frank
Publicado 2023

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

por Nchioua, Rayhane, Schundner, Annika, Klute, Susanne, Koepke, Lennart, Hirschenberger, Maximilian, Noettger, Sabrina, Fois, Giorgio, Zech, Fabian, Graf, Alexander, Krebs, Stefan, Braubach, Peter, Blum, Helmut, Stenger, Steffen, Kmiec, Dorota, Frick, Manfred, Kirchhoff, Frank, Sparrer, Konstantin MJ
Publicado 2023

Spike residue 403 affects binding of coronavirus spikes to human ACE2

por Zech, Fabian, Schniertshauer, Daniel, Jung, Christoph, Herrmann, Alexandra, Cordsmeier, Arne, Xie, Qinya, Nchioua, Rayhane, Prelli Bozzo, Caterina, Volcic, Meta, Koepke, Lennart, Müller, Janis A., Krüger, Jana, Heller, Sandra, Stenger, Steffen, Hoffmann, Markus, Pöhlmann, Stefan, Kleger, Alexander, Jacob, Timo, Conzelmann, Karl-Klaus, Ensser, Armin, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2021

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

por Hayn, Manuel, Hirschenberger, Maximilian, Koepke, Lennart, Nchioua, Rayhane, Straub, Jan Hendrik, Klute, Susanne, Hunszinger, Victoria, Zech, Fabian, Prelli Bozzo, Caterina, Aftab, Wasim, Christensen, Maria Hønholt, Conzelmann, Carina, Müller, Janis Alexander, Srinivasachar Badarinarayan, Smitha, Stürzel, Christina Martina, Forne, Ignasi, Stenger, Steffen, Conzelmann, Karl-Klaus, Münch, Jan, Schmidt, Florian Ingo, Sauter, Daniel, Imhof, Axel, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes
Publicado 2021

Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains

por González-García, Melaine, Morales-Vicente, Fidel, Pico, Erbio Díaz, Garay, Hilda, Rivera, Daniel G., Grieshober, Mark, Raluca Olari, Lia, Groß, Rüdiger, Conzelmann, Carina, Krüger, Franziska, Zech, Fabian, Prelli Bozzo, Caterina, Müller, Janis A., Zelikin, Alexander, Raber, Heinz, Kubiczek, Dennis, Rosenau, Frank, Münch, Jan, Stenger, Steffen, Spellerberg, Barbara, Franco, Octavio L., Rodriguez Alfonso, Armando A., Ständker, Ludger, Otero-Gonzalez, Anselmo J.
Publicado 2021

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

por Wettstein, Lukas, Weil, Tatjana, Conzelmann, Carina, Müller, Janis A., Groß, Rüdiger, Hirschenberger, Maximilian, Seidel, Alina, Klute, Susanne, Zech, Fabian, Prelli Bozzo, Caterina, Preising, Nico, Fois, Giorgio, Lochbaum, Robin, Knaff, Philip Maximilian, Mailänder, Volker, Ständker, Ludger, Thal, Dietmar Rudolf, Schumann, Christian, Stenger, Steffen, Kleger, Alexander, Lochnit, Günter, Mayer, Benjamin, Ruiz-Blanco, Yasser B., Hoffmann, Markus, Sparrer, Konstantin M. J., Pöhlmann, Stefan, Sanchez-Garcia, Elsa, Kirchhoff, Frank, Frick, Manfred, Münch, Jan
Publicado 2021

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

por Prelli Bozzo, Caterina, Nchioua, Rayhane, Volcic, Meta, Koepke, Lennart, Krüger, Jana, Schütz, Desiree, Heller, Sandra, Stürzel, Christina M., Kmiec, Dorota, Conzelmann, Carina, Müller, Janis, Zech, Fabian, Braun, Elisabeth, Groß, Rüdiger, Wettstein, Lukas, Weil, Tatjana, Weiß, Johanna, Diofano, Federica, Rodríguez Alfonso, Armando A., Wiese, Sebastian, Sauter, Daniel, Münch, Jan, Goffinet, Christine, Catanese, Alberto, Schön, Michael, Boeckers, Tobias M., Stenger, Steffen, Sato, Kei, Just, Steffen, Kleger, Alexander, Sparrer, Konstantin M. J., Kirchhoff, Frank
Publicado 2021

The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties

por Olari, Lia-Raluca, Bauer, Richard, Gil Miró, Marta, Vogel, Verena, Cortez Rayas, Laura, Groß, Rüdiger, Gilg, Andrea, Klevesath, Raphael, Rodríguez Alfonso, Armando A., Kaygisiz, Kübra, Rupp, Ulrich, Pant, Pradeep, Mieres-Pérez, Joel, Steppe, Lena, Schäffer, Ramona, Rauch-Wirth, Lena, Conzelmann, Carina, Müller, Janis A., Zech, Fabian, Gerbl, Fabian, Bleher, Jana, Preising, Nico, Ständker, Ludger, Wiese, Sebastian, Thal, Dietmar R., Haupt, Christian, Jonker, Hendrik R. A., Wagner, Manfred, Sanchez-Garcia, Elsa, Weil, Tanja, Stenger, Steffen, Fändrich, Marcus, von Einem, Jens, Read, Clarissa, Walther, Paul, Kirchhoff, Frank, Spellerberg, Barbara, Münch, Jan
Publicado 2023