The Role of ATR Inhibitors in Ovarian Cancer: Investigating Predictive Biomarkers of Response

por Bradbury, Alice, Zenke, Frank T., Curtin, Nicola J., Drew, Yvette
Publicado 2022

Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death

por Chiu, Li-Ya, Sun, Qing, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2023

Modeling the Effect of Hypoxia and DNA Repair Inhibition on Cell Survival after Photon Irradiation

por Liew, Hans, Klein, Carmen, Zenke, Frank T., Abdollahi, Amir, Debus, Jürgen, Dokic, Ivana, Mairani, Andrea
Publicado 2019

DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia

por Carr, Michael I., Zimmermann, Astrid, Chiu, Li-Ya, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2020

Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality

por Benfatto, Salvatore, Serçin, Özdemirhan, Dejure, Francesca R., Abdollahi, Amir, Zenke, Frank T., Mardin, Balca R.
Publicado 2021

Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors

por Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2023

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies

por Zimmermann, Astrid, Zenke, Frank T., Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T., Blaukat, Andree
Publicado 2022

A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice

por Roidos, Paris, Sungalee, Stephanie, Benfatto, Salvatore, Serçin, Özdemirhan, Stütz, Adrian M., Abdollahi, Amir, Mauer, Jan, Zenke, Frank T., Korbel, Jan O., Mardin, Balca R.
Publicado 2020

DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia

por Haines, Eric, Nishida, Yuki, Carr, Michael I., Montoya, Rafael Heinz, Ostermann, Lauren B., Zhang, Weiguo, Zenke, Frank T., Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T.
Publicado 2021

Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

por Klein, Carmen, Dokic, Ivana, Mairani, Andrea, Mein, Stewart, Brons, Stephan, Häring, Peter, Haberer, Thomas, Jäkel, Oliver, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree, Debus, Jürgen, Abdollahi, Amir
Publicado 2017

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

por Jo, Ukhyun, Senatorov, Ilya S., Zimmermann, Astrid, Saha, Liton Kumar, Murai, Yasuhisa, Kim, Se Hyun, Rajapakse, Vinodh N., Elloumi, Fathi, Takahashi, Nobuyuki, Schultz, Christopher W., Thomas, Anish, Zenke, Frank T., Pommier, Yves
Publicado 2021

DNA-PK Inhibitor Peposertib Amplifies Radiation-Induced Inflammatory Micronucleation and Enhances TGFβ/PD-L1 Targeted Cancer Immunotherapy

por Carr, Michael I., Chiu, Li-Ya, Guo, Yige, Xu, Chunxiao, Lazorchak, Adam S., Yu, Huakui, Qin, Guozhong, Qi, Jin, Marelli, Bo, Lan, Yan, Sun, Qing, Czauderna, Frank, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado 2022

A solid‐phase transfection platform for arrayed CRISPR screens

por Serçin, Özdemirhan, Reither, Sabine, Roidos, Paris, Ballin, Nadja, Palikyras, Spyridon, Baginska, Anna, Rein, Katrin, Llamazares, Maria, Halavatyi, Aliaksandr, Winter, Hauke, Muley, Thomas, Jurkowska, Renata Z, Abdollahi, Amir, Zenke, Frank T, Neumann, Beate, Mardin, Balca R
Publicado 2019

ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma

por Seidel, Philipp, Rubarth, Anne, Zodel, Kyra, Peighambari, Asin, Neumann, Felix, Federkiel, Yannick, Huang, Hsin, Hoefflin, Rouven, Adlesic, Mojca, Witt, Christian, Hoffmann, David J., Metzger, Patrick, Lindemann, Ralph K., Zenke, Frank T., Schell, Christoph, Boerries, Melanie, von Elverfeldt, Dominik, Reichardt, Wilfried, Follo, Marie, Albers, Joachim, Frew, Ian J.
Publicado 2022

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

por Llorca-Cardenosa, Marta J., Aronson, Lauren I., Krastev, Dragomir B., Nieminuszczy, Jadwiga, Alexander, John, Song, Feifei, Dylewska, Malgorzata, Broderick, Ronan, Brough, Rachel, Zimmermann, Astrid, Zenke, Frank T., Gurel, Bora, Riisnaes, Ruth, Ferreira, Ana, Roumeliotis, Theodoros, Choudhary, Jyoti, Pettitt, Stephen J., de Bono, Johann, Cervantes, Andres, Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J., Chong, Irene Y.
Publicado 2022

ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer

por Schultz, Christopher W, Zhang, Yang, Elmeskini, Rajaa, Zimmermann, Astrid, Fu, Haiqing, Murai, Yasuhisa, Wangsa, Darawalee, Kumar, Suresh, Takahashi, Nobuyuki, Atkinson, Devon, Saha, Liton Kumar, Lee, Chien‐Fei, Elenbaas, Brian, Desai, Parth, Sebastian, Robin, Sharma, Ajit Kumar, Abel, Melissa, Schroeder, Brett, Krishnamurthy, Manan, Kumar, Rajesh, Roper, Nitin, Aladjem, Mirit, Zenke, Frank T, Ohler, Zoe Weaver, Pommier, Yves, Thomas, Anish
Publicado 2023