Aminopyrimidine–galactose hybrids are highly selective galectin-3 inhibitors

por Dahlqvist, Alexander, Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J.
Publicado 2019

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

por Dahlqvist, Alexander, Mandal, Santanu, Peterson, Kristoffer, Håkansson, Maria, Logan, Derek T., Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J.
Publicado 2019

Extracellular and intracellular small-molecule galectin-3 inhibitors

por Stegmayr, John, Zetterberg, Fredrik, Carlsson, Michael C., Huang, Xiaoli, Sharma, Gunjan, Kahl-Knutson, Barbro, Schambye, Hans, Nilsson, Ulf J., Oredsson, Stina, Leffler, Hakon
Publicado 2019

Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1

por Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.
Publicado 2023

Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands

por Peterson, Kristoffer, Collins, Patrick M., Huang, Xiaoli, Kahl-Knutsson, Barbro, Essén, Sofia, Zetterberg, Fredrik R., Oredsson, Stina, Leffler, Hakon, Blanchard, Helen, Nilsson, Ulf J.
Publicado 2018

Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants

por Aslanis, Vassilios, Slack, Robert J., MacKinnon, Alison C., McClinton, Catherine, Tantawi, Susan, Gravelle, Lise, Nilsson, Ulf J., Leffler, Hakon, Brooks, Ashley, Khindri, Sanjeev K., Marshall, Richard P., Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik
Publicado 2023

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease

por Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan
Publicado 2022

Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

por Hirani, Nikhil, MacKinnon, Alison C., Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J., Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J., Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L., Li, Feng, Funston, Wendy, Forrest, Ian A., Simpson, A. John, Gibbons, Michael A., Maher, Toby M.
Publicado 2021