Aminopyrimidine–galactose hybrids are highly selective galectin-3 inhibitors

por Dahlqvist, Alexander, Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J.
Publicado 2019

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3

por Dahlqvist, Alexander, Mandal, Santanu, Peterson, Kristoffer, Håkansson, Maria, Logan, Derek T., Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J.
Publicado 2019

Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1

por Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.
Publicado 2023

Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands

por Peterson, Kristoffer, Collins, Patrick M., Huang, Xiaoli, Kahl-Knutsson, Barbro, Essén, Sofia, Zetterberg, Fredrik R., Oredsson, Stina, Leffler, Hakon, Blanchard, Helen, Nilsson, Ulf J.
Publicado 2018

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease

por Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan
Publicado 2022