Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

por Zhan, Wuqiang, Tian, Xiaolong, Zhang, Xiang, Xing, Shenghui, Song, Wenping, Liu, Qianying, Hao, Aihua, Hu, Yuxia, Zhang, Meng, Ying, Tianlei, Chen, Zhenguo, Lan, Fei, Sun, Lei
Publicado 2022

A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding

por Wang, Yingdan, Zhan, Wuqiang, Liu, Jiangyan, Wang, Yanqun, Zhang, Xiang, Zhang, Meng, Han, Lin, Ma, Yunping, Lu, Lu, Wen, Yumei, Chen, Zhenguo, Zhao, Jincun, Wu, Fan, Sun, Lei, Huang, Jinghe
Publicado 2022

Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

por Wang, Yingdan, Zhang, Xiang, Ma, Yunping, Wang, Yanqun, Zhan, Wuqiang, Zheng, Qinwen, Zhang, Meng, Ji, Ping, Liu, Mei, Liu, Qianying, Sun, Tingting, Zhu, Tongyu, Wen, Yumei, Sun, Lei, Zhao, Jincun, Wu, Fan, Chen, Zhenguo, Huang, Jinghe
Publicado 2022

Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger

por Liu, Qianying, Zhang, Xiang, Huang, Hui, Chen, Yuxin, Wang, Fang, Hao, Aihua, Zhan, Wuqiang, Mao, Qiyu, Hu, Yuxia, Han, Lin, Sun, Yifang, Zhang, Meng, Liu, Zhimin, Li, Geng-Lin, Zhang, Weijia, Shu, Yilai, Sun, Lei, Chen, Zhenguo
Publicado 2023

Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants

por Wu, Jianbo, Chen, Zhenguo, Gao, Yidan, Wang, Zegen, Wang, Jiarong, Chiang, Bing-Yu, Zhou, Yunjiao, Han, Yuru, Zhan, Wuqiang, Xie, Minxiang, Jiang, Weiyu, Zhang, Xiang, Hao, Aihua, Xia, Anqi, He, Jiaying, Xue, Song, Mayer, Christian T., Wu, Fan, Wang, Bin, Zhang, Lunan, Sun, Lei, Wang, Qiao
Publicado 2023

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

por Wu, Jianbo, Chen, Zhenguo, Gao, Yidan, Wang, Zegen, Wang, Jiarong, Chiang, Bing-Yu, Zhou, Yunjiao, Han, Yuru, Zhan, Wuqiang, Xie, Minxiang, Jiang, Weiyu, Zhang, Xiang, Hao, Aihua, Xia, Anqi, He, Jiaying, Xue, Song, Mayer, Christian T., Wu, Fan, Wang, Bin, Zhang, Lunan, Sun, Lei, Wang, Qiao
Publicado 2022

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

por Li, Cheng, Zhan, Wuqiang, Yang, Zhenlin, Tu, Chao, Hu, Gaowei, Zhang, Xiang, Song, Wenping, Du, Shujuan, Zhu, Yuanfei, Huang, Keke, Kong, Yu, Zhang, Meng, Mao, Qiyu, Gu, Xiaodan, Zhang, Yi, Xie, Youhua, Deng, Qiang, Song, Yuanlin, Chen, Zhenguo, Lu, Lu, Jiang, Shibo, Wu, Yanling, Sun, Lei, Ying, Tianlei
Publicado 2022

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

por Yang, Zhenlin, Wang, Yulu, Jin, Yujia, Zhu, Yuanfei, Wu, Yanling, Li, Cheng, Kong, Yu, Song, Wenping, Tian, Xiaolong, Zhan, Wuqiang, Huang, Ailing, Zhou, Shanshan, Xia, Shuai, Tian, Xiaoxu, Peng, Chao, Chen, Cuicui, Shi, Yibing, Hu, Gaowei, Du, Shujuan, Wang, Yuyan, Xie, Youhua, Jiang, Shibo, Lu, Lu, Sun, Lei, Song, Yuanlin, Ying, Tianlei
Publicado 2021

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

por Liu, Zezhong, Xu, Wei, Chen, Zhenguo, Fu, Wangjun, Zhan, Wuqiang, Gao, Yidan, Zhou, Jie, Zhou, Yunjiao, Wu, Jianbo, Wang, Qian, Zhang, Xiang, Hao, Aihua, Wu, Wei, Zhang, Qianqian, Li, Yaming, Fan, Kaiyue, Chen, Ruihong, Jiang, Qiaochu, Mayer, Christian T., Schoofs, Till, Xie, Youhua, Jiang, Shibo, Wen, Yumei, Yuan, Zhenghong, Wang, Kang, Lu, Lu, Sun, Lei, Wang, Qiao
Publicado 2021