BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner

por Lau, Ken S., Zhang, Tinghu, Kendall, Krystle R., Lauffenburger, Douglas, Gray, Nathanael S., Haigis, Kevin M.
Publicado 2012

Systematic analysis of BRAF(V)(600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

por Fallahi-Sichani, Mohammad, Moerke, Nathan J, Niepel, Mario, Zhang, Tinghu, Gray, Nathanael S, Sorger, Peter K
Publicado 2015

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

por Vollmer, Stefan, Strickson, Sam, Zhang, Tinghu, Gray, Nathanael, Lee, Katherine L., Rao, Vikram R., Cohen, Philip
Publicado 2017

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells

por Ho, Catherine M. K., Donovan-Banfield, I’ah Z., Tan, Li, Zhang, Tinghu, Gray, Nathanael S., Strang, Blair L.
Publicado 2016

Fragment-based covalent ligand discovery

por Lu, Wenchao, Kostic, Milka, Zhang, Tinghu, Che, Jianwei, Patricelli, Matthew P., Jones, Lyn H., Chouchani, Edward T., Gray, Nathanael S.
Publicado 2021

Correction: Fragment-based covalent ligand discovery

por Lu, Wenchao, Kostic, Milka, Zhang, Tinghu, Che, Jianwei, Patricelli, Matthew P., Jones, Lyn H., Chouchani, Edward T., Gray, Nathanael S.
Publicado 2021

Structure and Characterization of a Covalent Inhibitor of Src Kinase

por Gurbani, Deepak, Du, Guangyan, Henning, Nathaniel J., Rao, Suman, Bera, Asim K., Zhang, Tinghu, Gray, Nathanael S., Westover, Kenneth D.
Publicado 2020

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

por Faust, Tyler, Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.
Publicado 2019

Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

por Gao, Yang, Volegova, Marina, Nasholm, Nicole, Das, Sanjukta, Kwiatkowski, Nicholas, Abraham, Brian J., Zhang, Tinghu, Gray, Nathanael S., Gustafson, Clay, Krajewska, Malgorzata, George, Rani E.
Publicado 2022

Light-induced control of protein destruction by opto-PROTAC

por Liu, Jing, Chen, He, Ma, Leina, He, Zhixiang, Wang, Dong, Liu, Yi, Lin, Qian, Zhang, Tinghu, Gray, Nathanael, Kaniskan, H. Ümit, Jin, Jian, Wei, Wenyi
Publicado 2020

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

por de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.
Publicado 2019

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

por Zarei, Mahsa, Du, Heng, Nassar, Amin H., Yan, Rachel E., Giannikou, Krinio, Johnson, Sneha H., Lam, Hilaire C., Henske, Elizabeth P., Wang, Yubao, Zhang, Tinghu, Asara, John, Kwiatkowski, David J.
Publicado 2019

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

por Silva, M Catarina, Ferguson, Fleur M, Cai, Quan, Donovan, Katherine A, Nandi, Ghata, Patnaik, Debasis, Zhang, Tinghu, Huang, Hai-Tsang, Lucente, Diane E, Dickerson, Bradford C, Mitchison, Timothy J, Fischer, Eric S, Gray, Nathanael S, Haggarty, Stephen J
Publicado 2019

Plasticity in binding confers selectivity in ligand induced protein degradation

por Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.
Publicado 2018

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

por Cayrol, Florencia, Praditsuktavorn, Pannee, Fernando, Tharu M., Kwiatkowski, Nicholas, Marullo, Rosella, Calvo-Vidal, M. Nieves, Phillip, Jude, Pera, Benet, Yang, Shao Ning, Takpradit, Kaipol, Roman, Lidia, Gaudiano, Marcello, Crescenzo, Ramona, Ruan, Jia, Inghirami, Giorgio, Zhang, Tinghu, Cremaschi, Graciela, Gray, Nathanael S., Cerchietti, Leandro
Publicado 2017

Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

por Cayrol, Florencia, Praditsuktavorn, Pannee, Fernando, Tharu M., Kwiatkowski, Nicholas, Marullo, Rossella, Calvo-Vidal, M. Nieves, Phillip, Jude, Pera, Benet, Yang, Shao Ning, Takpradit, Kaipol, Roman, Lidia, Gaudiano, Marcello, Crescenzo, Ramona, Ruan, Jia, Inghirami, Giorgio, Zhang, Tinghu, Cremaschi, Graciela, Gray, Nathanael S, Cerchietti, Leandro
Publicado 2017

Targeting transcription in heart failure via CDK7/12/13 inhibition

por Hsu, Austin, Duan, Qiming, Day, Daniel S., Luo, Xin, McMahon, Sarah, Huang, Yu, Feldman, Zachary B., Jiang, Zhen, Zhang, Tinghu, Liang, Yanke, Alexanian, Michael, Padmanabhan, Arun, Brown, Jonathan D., Lin, Charles Y., Gray, Nathanael S., Young, Richard A., Bruneau, Benoit G., Haldar, Saptarsi M.
Publicado 2022

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

por Krajewska, Malgorzata, Dries, Ruben, Grassetti, Andrew V., Dust, Sofia, Gao, Yang, Huang, Hao, Sharma, Bandana, Day, Daniel S., Kwiatkowski, Nicholas, Pomaville, Monica, Dodd, Oliver, Chipumuro, Edmond, Zhang, Tinghu, Greenleaf, Arno L., Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., Geyer, Matthias, Gerber, Scott A., George, Rani E.
Publicado 2019

MELK is not necessary for the proliferation of basal-like breast cancer cells

por Huang, Hai-Tsang, Seo, Hyuk-Soo, Zhang, Tinghu, Wang, Yubao, Jiang, Baishan, Li, Qing, Buckley, Dennis L, Nabet, Behnam, Roberts, Justin M, Paulk, Joshiawa, Dastjerdi, Shiva, Winter, Georg E, McLauchlan, Hilary, Moran, Jennifer, Bradner, James E, Eck, Michael J, Dhe-Paganon, Sirano, Zhao, Jean J, Gray, Nathanael S
Publicado 2017

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

por Zeng, Mei, Kwiatkowski, Nicholas P, Zhang, Tinghu, Nabet, Behnam, Xu, Mousheng, Liang, Yanke, Quan, Chunshan, Wang, Jinhua, Hao, Mingfeng, Palakurthi, Sangeetha, Zhou, Shan, Zeng, Qing, Kirschmeier, Paul T, Meghani, Khyati, Leggett, Alan L, Qi, Jun, Shapiro, Geoffrey I, Liu, Joyce F, Matulonis, Ursula A, Lin, Charles Y, Konstantinopoulos, Panagiotis A, Gray, Nathanael S
Publicado 2018