Leveraging a physiologically-based quantitative translational modeling platform for designing B cell maturation antigen-targeting bispecific T cell engagers for treatment of multip...

por Yoneyama, Tomoki, Kim, Mi-Sook, Piatkov, Konstantin, Wang, Haiqing, Zhu, Andy Z. X.
Publicado 2022

A Citrulline‐Based Translational Population System Toxicology Model for Gastrointestinal‐Related Adverse Events Associated With Anticancer Treatments

por Yoneyama, Tomoki, Abdul‐Hadi, Kojo, Brown, Adam, Guan, Emily, Wagoner, Matt, Zhu, Andy Z.X.
Publicado 2019

Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake

por Zhu, Andy Z. X., Zhou, Qian, Cox, Lisa Sanderson, Ahluwalia, Jasjit S., Benowitz, Neal L., Tyndale, Rachel F.
Publicado 2013

C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration

por Akinola, Lois S., Mckiver, Bryan, Toma, Wisam, Zhu, Andy Z. X., Tyndale, Rachel F., Kumar, Vivek, Damaj, M. Imad
Publicado 2019

Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African American smokers

por Zhu, Andy Z.X., Zhou, Qian, Cox, Lisa Sanderson, David, Sean P., Ahluwalia, Jasjit S., Benowitz, Neal L., Tyndale, Rachel F.
Publicado 2014

Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice

por Alsharari, Shakir D., King, Justin R., Nordman, Jacob C., Muldoon, Pretal P., Jackson, Asti, Zhu, Andy Z. X., Tyndale, Rachel F., Kabbani, Nadine, Damaj, M. Imad.
Publicado 2015

Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking

por Tyndale, Rachel F., Zhu, Andy Z. X., George, Tony P., Cinciripini, Paul, Hawk, Larry W., Schnoll, Robert A., Swan, Gary E., Benowitz, Neal L., Heitjan, Daniel F., Lerman, Caryn
Publicado 2015

Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model

por Chen, Yuan, Cabalu, Tamara D., Callegari, Ernesto, Einolf, Heidi, Liu, Lichuan, Parrott, Neil, Peters, Sheila Annie, Schuck, Edgar, Sharma, Pradeep, Tracey, Helen, Upreti, Vijay V., Zheng, Ming, Zhu, Andy Z.X., Hall, Stephen D.
Publicado 2019

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

por El‐Boraie, Ahmed, Tanner, Julie‐Anne, Zhu, Andy Z.X., Claw, Katrina G., Prasad, Bhagwat, Schuetz, Erin G., Thummel, Kenneth E., Fukunaga, Koya, Mushiroda, Taisei, Kubo, Michiaki, Benowitz, Neal L., Lerman, Caryn, Tyndale, Rachel F.
Publicado 2021

Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury

por Wolenski, Francis S., Zhu, Andy Z. X., Johnson, Mike, Yu, Shaoxia, Moriya, Yuu, Ebihara, Takuya, Csizmadia, Vilmos, Grieves, Jessica, Paton, Martin, Liao, Mingxiang, Gemski, Christopher, Pan, Liping, Vakilynejad, Majid, Dragan, Yvonne P., Chowdhury, Swapan K., Kirby, Patrick J.
Publicado 2017

Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective

por Heimbach, Tycho, Chen, Yuan, Chen, Jun, Dixit, Vaishali, Parrott, Neil, Peters, Sheila Annie, Poggesi, Italo, Sharma, Pradeep, Snoeys, Jan, Shebley, Mohamad, Tai, Guoying, Tse, Susanna, Upreti, Vijay V., Wang, Ying‐Hong, Tsai, Alice, Xia, Binfeng, Zheng, Ming, Zhu, Andy Z.X., Hall, Stephen
Publicado 2020

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption

por Bergen, Andrew W., Michel, Martha, Nishita, Denise, Krasnow, Ruth, Javitz, Harold S., Conneely, Karen N., Lessov-Schlaggar, Christina N., Hops, Hyman, Zhu, Andy Z. X., Baurley, James W., McClure, Jennifer B., Hall, Sharon M., Baker, Timothy B., Conti, David V., Benowitz, Neal L., Lerman, Caryn, Tyndale, Rachel F., Swan, Gary E.
Publicado 2015

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2

por Ware, Jennifer J., Chen, Xiangning, Vink, Jacqueline, Loukola, Anu, Minica, Camelia, Pool, Rene, Milaneschi, Yuri, Mangino, Massimo, Menni, Cristina, Chen, Jingchun, Peterson, Roseann E., Auro, Kirsi, Lyytikäinen, Leo-Pekka, Wedenoja, Juho, Stiby, Alexander I., Hemani, Gibran, Willemsen, Gonneke, Hottenga, Jouke Jan, Korhonen, Tellervo, Heliövaara, Markku, Perola, Markus, Rose, Richard J., Paternoster, Lavinia, Timpson, Nic, Wassenaar, Catherine A., Zhu, Andy Z. X., Davey Smith, George, T. Raitakari, Olli, Lehtimäki, Terho, Kähönen, Mika, Koskinen, Seppo, Spector, Timothy, Penninx, Brenda W. J. H., Salomaa, Veikko, Boomsma, Dorret I., Tyndale, Rachel F., Kaprio, Jaakko, Munafò, Marcus R.
Publicado 2016

Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

por Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., van der Graaf, Piet H., Kierzek, Andrzej M.
Publicado 2020