Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer

por Zimmerman, Mark W., Homanics, Gregg E., Lazo, John S.
Publicado 2013

Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights

por Shendy, Noha A.M., Zimmerman, Mark W., Abraham, Brian J., Durbin, Adam D.
Publicado 2022

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

por Shi, Hui, Tao, Ting, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Kadoch, Cigall, Look, A. Thomas
Publicado 2020

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

por Oppel, Felix, Tao, Ting, Shi, Hui, Ross, Kenneth N., Zimmerman, Mark W., He, Shuning, Tong, Guangxiang, Aster, Jon C., Look, A. Thomas
Publicado 2019

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

por Oppel, Felix, Ki, Dong H., Zimmerman, Mark W., Ross, Kenneth N., Tao, Ting, Shi, Hui, He, Shuning, Aster, Jon C., Look, A. Thomas
Publicado 2020

Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma

por Zimmerman, Mark W., Durbin, Adam D., He, Shuning, Oppel, Felix, Shi, Hui, Tao, Ting, Li, Zhaodong, Berezovskaya, Alla, Liu, Yu, Zhang, Jinghui, Young, Richard A., Abraham, Brian J., Look, A. Thomas
Publicado 2021

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

por He, Shuning, Mansour, Marc R, Zimmerman, Mark W, Ki, Dong Hyuk, Layden, Hillary M, Akahane, Koshi, Gjini, Evisa, de Groh, Eric D, Perez-Atayde, Antonio R, Zhu, Shizhen, Epstein, Jonathan A, Look, A Thomas
Publicado 2016

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

por Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas
Publicado 2020

Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state

por Weichert-Leahey, Nina, Shi, Hui, Tao, Ting, Oldridge, Derek A., Durbin, Adam D., Abraham, Brian J., Zimmerman, Mark W., Zhu, Shizhen, Wood, Andrew C., Reyon, Deepak, Joung, J. Keith, Young, Richard A., Diskin, Sharon J., Maris, John M., Look, A. Thomas
Publicado 2023

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

por He, Shuning, Zimmerman, Mark W., Layden, Hillary M., Berezovskaya, Alla, Etchin, Julia, Martel, Megan W., Thurston, Grace, Jing, Chang-Bin, van Rooijen, Ellen, Kaufman, Charles K., Rodig, Scott J., Zon, Leonard I., Patton, E. Elizabeth, Mansour, Marc R., Look, A. Thomas
Publicado 2021

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

por Wang, Lu, Tan, Tze King, Durbin, Adam D., Zimmerman, Mark W., Abraham, Brian J., Tan, Shi Hao, Ngoc, Phuong Cao Thi, Weichert-Leahey, Nina, Akahane, Koshi, Lawton, Lee N., Rokita, Jo Lynne, Maris, John M., Young, Richard A., Look, A. Thomas, Sanda, Takaomi
Publicado 2019

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

por Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly
Publicado 2018

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

por De Wyn, Jolien, Zimmerman, Mark W., Weichert-Leahey, Nina, Nunes, Carolina, Cheung, Belamy B., Abraham, Brian J., Beckers, Anneleen, Volders, Pieter-Jan, Decaesteker, Bieke, Carter, Daniel R., Look, Alfred Thomas, De Preter, Katleen, Van Loocke, Wouter, Marshall, Glenn M., Durbin, Adam D., Speleman, Frank, Durinck, Kaat
Publicado 2021

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

por Mansour, Marc R., He, Shuning, Li, Zhaodong, Lobbardi, Riadh, Abraham, Brian J., Hug, Clemens, Rahman, Sunniyat, Leon, Theresa E., Kuang, You-Yi, Zimmerman, Mark W., Blonquist, Traci, Gjini, Evisa, Gutierrez, Alejandro, Tang, Qin, Garcia-Perez, Laura, Pike-Overzet, Karin, Anders, Lars, Berezovskaya, Alla, Zhou, Yi, Zon, Leonard I., Neuberg, Donna, Fielding, Adele K., Staal, Frank J.T., Langenau, David M., Sanda, Takaomi, Young, Richard A., Look, A. Thomas
Publicado 2018

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

por Durbin, Adam D., Wang, Tingjian, Wimalasena, Virangika K., Zimmerman, Mark W., Li, Deyao, Dharia, Neekesh V., Mariani, Luca, Shendy, Noha A.M., Nance, Stephanie, Patel, Anand G., Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M.C., Sigua, Logan H., Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L., Perez-Atayde, Antonio R., Bikowitz, Melissa J., Quinn, Taylor R., Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L., Abraham, Brian J., Stegmaier, Kimberly, Look, A. Thomas, Qi, Jun
Publicado 2022

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

por Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf
Publicado 2021