Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B

por Rogers, Geoffrey L, Martino, Ashley T, Zolotukhin, Irene, Ertl, Hildegund CJ, Herzog, Roland W
Publicado 2014

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

por Zolotukhin, Irene, Markusic, David M, Palaschak, Brett, Hoffman, Brad E, Srikanthan, Meera A, Herzog, Roland W
Publicado 2016

Dynamics of antigen presentation to transgene product-specific CD4(+) T cells and of Treg induction upon hepatic AAV gene transfer

por Perrin, George Q, Zolotukhin, Irene, Sherman, Alexandra, Biswas, Moanaro, de Jong, Ype P, Terhorst, Cox, Davidoff, Andrew M, Herzog, Roland W
Publicado 2016

Effect of CpG Depletion of Vector Genome on CD8(+) T Cell Responses in AAV Gene Therapy

por Bertolini, Thais B., Shirley, Jamie L., Zolotukhin, Irene, Li, Xin, Kaisho, Tsuneyasu, Xiao, Weidong, Kumar, Sandeep R. P., Herzog, Roland W.
Publicado 2021

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

por Markusic, David M., Nichols, Timothy C., Merricks, Elizabeth P., Palaschak, Brett, Zolotukhin, Irene, Marsic, Damien, Zolotukhin, Sergei, Srivastava, Arun, Herzog, Roland W.
Publicado 2017

Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity

por Biswas, Moanaro, Marsic, Damien, Li, Ning, Zou, Chenhui, Gonzalez-Aseguinolaza, Gloria, Zolotukhin, Irene, Kumar, Sandeep R.P., Rana, Jyoti, Butterfield, John S.S., Kondratov, Oleksandr, de Jong, Ype P., Herzog, Roland W., Zolotukhin, Sergei
Publicado 2020