Confirmatory detection of neutralizing antibodies to AAV gene therapy using a cell-based transduction inhibition assay

por Kasprzyk, Theresa, Triffault, Sabrina, Long, Brian R., Zoog, Stephen J., Vettermann, Christian
Publicado 2022

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

por Cheung, Ruby, deHart, Gregory W., Jesaitis, Lynne, Zoog, Stephen J., Melton, Andrew C.
Publicado 2018

Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates

por Yang, Fan, Patton, Kathryn, Kasprzyk, Theresa, Long, Brian, Gupta, Soumi, Zoog, Stephen J., Tracy, Kristin, Vettermann, Christian
Publicado 2021

Monitoring cell-mediated immune responses in AAV gene therapy clinical trials using a validated IFN-γ ELISpot method

por Patton, Kathryn S., Harrison, M. Travis, Long, Brian R., Lau, Kelly, Holcomb, Jennifer, Owen, Rachel, Kasprzyk, Theresa, Janetzki, Sylvia, Zoog, Stephen J., Vettermann, Christian
Publicado 2021

AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues

por Juan, Gloria, Bush, Tammy L, Ma, Connie, Manoukian, Raffi, Chung, Grace, Hawkins, Jennifer M, Zoog, Stephen, Kendall, Richard, Radinsky, Robert, Loberg, Robert, Friberg, Greg, Payton, Marc
Publicado 2014

The Impact of Pre-existing Immunity on the Non-clinical Pharmacodynamics of AAV5-Based Gene Therapy

por Long, Brian R., Sandza, Krystal, Holcomb, Jennifer, Crockett, Lucy, Hayes, Gregory M., Arens, Jeremy, Fonck, Carlos, Tsuruda, Laurie S., Schweighardt, Becky, O’Neill, Charles A., Zoog, Stephen, Vettermann, Christian
Publicado 2019

Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer

por Sandza, Krystal, Clark, Annie, Koziol, Elli, Akeefe, Hassibullah, Yang, Fan, Holcomb, Jennifer, Patton, Kathryn, Hammon, Kevin, Mitchell, Nina, Wong, Wing Y., Zoog, Stephen J., Kim, Benjamin, Henshaw, Joshua, Vettermann, Christian
Publicado 2021

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A

por Long, Brian R., Veron, Philippe, Kuranda, Klaudia, Hardet, Romain, Mitchell, Nina, Hayes, Gregory M., Wong, Wing Yen, Lau, Kelly, Li, Mingjin, Hock, M. Benjamin, Zoog, Stephen J., Vettermann, Christian, Mingozzi, Federico, Schweighardt, Becky
Publicado 2021

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials

por Gupta, Soumi, Lau, Kelly, Harding, Cary O., Shepherd, Gillian, Boyer, Ryan, Atkinson, John P., Knight, Vijaya, Olbertz, Joy, Larimore, Kevin, Gu, Zhonghu, Li, Mingjin, Rosen, Orli, Zoog, Stephen J., Weng, Haoling H., Schweighardt, Becky
Publicado 2018

Pharmacokinetic, pharmacodynamic, and immunogenic rationale for optimal dosing of pegvaliase, a PEGylated bacterial enzyme, in adult patients with phenylketonuria

por Qi, Yulan, Patel, Gina, Henshaw, Joshua, Gupta, Soumi, Olbertz, Joy, Larimore, Kevin, Harding, Cary O., Merilainen, Markus, Zori, Roberto, Longo, Nicola, Burton, Barbara K., Li, Mingjin, Gu, Zhonghua, Zoog, Stephen J., Weng, Haoling H., Schweighardt, Becky
Publicado 2021