Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of β-Thalassemia and Sickle-Cell Anemia

por Bianchi, Nicoletta, Zuccato, Cristina, Lampronti, Ilaria, Borgatti, Monica, Gambari, Roberto
Publicado 2009

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β(0)39-Globin Gene Editing and Induction of Fetal Hemoglobin

por Cosenza, Lucia Carmela, Zuccato, Cristina, Zurlo, Matteo, Gambari, Roberto, Finotti, Alessia
Publicado 2022

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study

por Gamberini, Maria Rita, Zuccato, Cristina, Zurlo, Matteo, Cosenza, Lucia Carmela, Finotti, Alessia, Gambari, Roberto
Publicado 2023

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences

por Finotti, Alessia, Gasparello, Jessica, Zuccato, Cristina, Cosenza, Lucia Carmela, Fabbri, Enrica, Bianchi, Nicoletta, Gambari, Roberto
Publicado 2023

Efficient CRISPR-Cas9-based genome editing of β-globin gene on erythroid cells from homozygous β(0)39-thalassemia patients

por Cosenza, Lucia Carmela, Gasparello, Jessica, Romanini, Nicola, Zurlo, Matteo, Zuccato, Cristina, Gambari, Roberto, Finotti, Alessia
Publicado 2021

A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs

por Prosdocimi, Marco, Zuccato, Cristina, Cosenza, Lucia Carmela, Borgatti, Monica, Lampronti, Ilaria, Finotti, Alessia, Gambari, Roberto
Publicado 2022

Induction of erythroid differentiation and increased globin mRNA production with furocoumarins and their photoproducts

por Salvador, Alessia, Brognara, Eleonora, Vedaldi, Daniela, Castagliuolo, Ignazio, Brun, Paola, Zuccato, Cristina, Lampronti, Ilaria, Gambari, Roberto
Publicado 2013

BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression

por Gasparello, Jessica, Fabbri, Enrica, Bianchi, Nicoletta, Breveglieri, Giulia, Zuccato, Cristina, Borgatti, Monica, Gambari, Roberto, Finotti, Alessia
Publicado 2017

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy

por Zurlo, Matteo, Gasparello, Jessica, Cosenza, Lucia Carmela, Breveglieri, Giulia, Papi, Chiara, Zuccato, Cristina, Gambari, Roberto, Finotti, Alessia
Publicado 2023

Recent trends in the gene therapy of β-thalassemia

por Finotti, Alessia, Breda, Laura, Lederer, Carsten W, Bianchi, Nicoletta, Zuccato, Cristina, Kleanthous, Marina, Rivella, Stefano, Gambari, Roberto
Publicado 2015

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production

por Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Lampronti, Ilaria, Borgatti, Monica, Scapoli, Chiara, Gambari, Roberto, Finotti, Alessia
Publicado 2021

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike s...

por Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Cosenza, Lucia Carmela, Breveglieri, Giulia, Zuccato, Cristina, Gambari, Roberto, Finotti, Alessia
Publicado 2022

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathie...

por Gambari, Roberto, Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Gasparello, Jessica, Finotti, Alessia, Gamberini, Maria Rita, Prosdocimi, Marco
Publicado 2023

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus

por Zurlo, Matteo, Zuccato, Cristina, Cosenza, Lucia Carmela, Gasparello, Jessica, Gamberini, Maria Rita, Stievano, Alice, Fortini, Monica, Prosdocimi, Marco, Finotti, Alessia, Gambari, Roberto
Publicado 2023

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

por Zuccato, Cristina, Breda, Laura, Salvatori, Francesca, Breveglieri, Giulia, Gardenghi, Sara, Bianchi, Nicoletta, Brognara, Eleonora, Lampronti, Ilaria, Borgatti, Monica, Rivella, Stefano, Gambari, Roberto
Publicado 2012

Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid C...

por Bianchi, Nicoletta, Finotti, Alessia, Ferracin, Manuela, Lampronti, Ilaria, Zuccato, Cristina, Breveglieri, Giulia, Brognara, Eleonora, Fabbri, Enrica, Borgatti, Monica, Negrini, Massimo, Gambari, Roberto
Publicado 2015

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated wi...

por Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Breveglieri, Giulia, Bianchi, Nicoletta, Lampronti, Ilaria, Gasparello, Jessica, Scapoli, Chiara, Borgatti, Monica, Finotti, Alessia, Gambari, Roberto
Publicado 2023

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production

por Breveglieri, Giulia, Bianchi, Nicoletta, Cosenza, Lucia Carmela, Gamberini, Maria Rita, Chiavilli, Francesco, Zuccato, Cristina, Montagner, Giulia, Borgatti, Monica, Lampronti, Ilaria, Finotti, Alessia, Gambari, Roberto
Publicado 2017

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening

por Breveglieri, Giulia, Pacifico, Salvatore, Zuccato, Cristina, Cosenza, Lucia Carmela, Sultan, Shaiq, D’Aversa, Elisabetta, Gambari, Roberto, Preti, Delia, Trapella, Claudio, Guerrini, Remo, Borgatti, Monica
Publicado 2020

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4 (+) and CD8 (+) T cells

por Zurlo, Matteo, Nicoli, Francesco, Proietto, Davide, Dallan, Beatrice, Zuccato, Cristina, Cosenza, Lucia Carmela, Gasparello, Jessica, Papi, Chiara, d'Aversa, Elisabetta, Borgatti, Monica, Scapoli, Chiara, Finotti, Alessia, Gambari, Roberto
Publicado 2023