The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

por Balta, Denise, Zunke, Friederike
Publicado 2021

Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases

por Prieto Huarcaya, Susy, Zunke, Friederike
Publicado 2022

Editorial: Intracellular Mechanisms of α-Synuclein Processing

por Zunke, Friederike, Winner, Beate, Richter, Franziska, Caraveo, Gabriela
Publicado 2021

Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants

por Socher, Eileen, Heger, Lukas, Paulsen, Friedrich, Zunke, Friederike, Arnold, Philipp
Publicado 2022

Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease

por Drobny, Alice, Ngo, Phuong A., Neurath, Markus F., Zunke, Friederike, López-Posadas, Rocío
Publicado 2021

Alpha Synuclein Connects the Gut-Brain Axis in Parkinson’s Disease Patients – A View on Clinical Aspects, Cellular Pathology and Analytical Methodology

por Schaeffer, Eva, Kluge, Annika, Böttner, Martina, Zunke, Friederike, Cossais, Francois, Berg, Daniela, Arnold, Philipp
Publicado 2020

Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide

por Socher, Eileen, Conrad, Marcus, Heger, Lukas, Paulsen, Friedrich, Sticht, Heinrich, Zunke, Friederike, Arnold, Philipp
Publicado 2021

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation

por Pavlenko, Egor, Cabron, Anne-Sophie, Arnold, Philipp, Dobert, Jan Philipp, Rose-John, Stefan, Zunke, Friederike
Publicado 2019

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain

por Dobert, Jan Philipp, Cabron, Anne-Sophie, Arnold, Philipp, Pavlenko, Egor, Rose-John, Stefan, Zunke, Friederike
Publicado 2020

The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis

por Leupold, Lukas, Sigutova, Veronika, Gerasimova, Elizaveta, Regensburger, Martin, Zundler, Sebastian, Zunke, Friederike, Xiang, Wei, Winner, Beate, Prots, Iryna
Publicado 2022

LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease

por Rothaug, Michelle, Stroobants, Stijn, Schweizer, Michaela, Peters, Judith, Zunke, Friederike, Allerding, Mirka, D’Hooge, Rudi, Saftig, Paul, Blanz, Judith
Publicado 2015

Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

por Bunk, Josina, Prieto Huarcaya, Susy, Drobny, Alice, Dobert, Jan Philipp, Walther, Lina, Rose-John, Stefan, Arnold, Philipp, Zunke, Friederike
Publicado 2021

Corrigendum: Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

por Bunk, Josina, Prieto Huarcaya, Susy, Drobny, Alice, Dobert, Jan Philipp, Walther, Lina, Rose-John, Stefan, Arnold, Philipp, Zunke, Friederike
Publicado 2021

Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles

por Lückstädt, Wiebke, Bub, Simon, Koudelka, Tomas, Pavlenko, Egor, Peters, Florian, Somasundaram, Prasath, Becker-Pauly, Christoph, Lucius, Ralph, Zunke, Friederike, Arnold, Philipp
Publicado 2021

Proteolysis of CD44 at the cell surface controls a downstream protease network

por Wöhner, Birte, Li, Wenjia, Hey, Sven, Drobny, Alice, Werny, Ludwig, Becker-Pauly, Christoph, Lucius, Ralph, Zunke, Friederike, Linder, Stefan, Arnold, Philipp
Publicado 2023

Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson’s Patient-Derived Neuronal Cells

por Seebauer, Lukas, Schneider, Yanni, Drobny, Alice, Plötz, Sonja, Koudelka, Tomas, Tholey, Andreas, Prots, Iryna, Winner, Beate, Zunke, Friederike, Winkler, Jürgen, Xiang, Wei
Publicado 2022

Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models

por Drobny, Alice, Boros, Fanni Annamária, Balta, Denise, Prieto Huarcaya, Susy, Caylioglu, Deniz, Qazi, Niyeti, Vandrey, Julia, Schneider, Yanni, Dobert, Jan Philipp, Pitcairn, Caleb, Mazzulli, Joseph Robert, Zunke, Friederike
Publicado 2023

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

por Gaspar, Paulo, Kallemeijn, Wouter W., Strijland, Anneke, Scheij, Saskia, Van Eijk, Marco, Aten, Jan, Overkleeft, Herman S., Balreira, Andrea, Zunke, Friederike, Schwake, Michael, Sá Miranda, Clara, Aerts, Johannes M. F. G.
Publicado 2014

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

por Cabron, Anne-Sophie, El azzouzi, Karim, Boss, Melanie, Arnold, Philipp, Schwarz, Jeanette, Rosas, Marcela, Dobert, Jan Philipp, Pavlenko, Egor, Schumacher, Neele, Renné, Thomas, Taylor, Philip R., Linder, Stefan, Rose-John, Stefan, Zunke, Friederike
Publicado 2018

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

por Prieto Huarcaya, Susy, Drobny, Alice, Marques, André R. A., Di Spiezio, Alessandro, Dobert, Jan Philipp, Balta, Denise, Werner, Christian, Rizo, Tania, Gallwitz, Lisa, Bub, Simon, Stojkovska, Iva, Belur, Nandkishore R., Fogh, Jens, Mazzulli, Joseph R, Xiang, Wei, Fulzele, Amitkumar, Dejung, Mario, Sauer, Markus, Winner, Beate, Rose-John, Stefan, Arnold, Philipp, Saftig, Paul, Zunke, Friederike
Publicado 2022