The Challenge of Targeting Notch in Hematologic Malignancies

por Hernandez Tejada, Fiorela N., Galvez Silva, Jorge R., Zweidler-McKay, Patrick A.
Publicado 2014

Regulation of NOTCH Signaling by Reciprocal Inhibition of HES1 and Deltex 1 and its Role in Osteosarcoma Invasiveness

por Zhang, Pingyu, Yang, Yanwen, Nolo, Riitta, Zweidler-McKay, Patrick A, Hughes, Dennis P M
Publicado 2010

Characterization of TRKA signaling in acute myeloid leukemia

por Herbrich, Shelley M., Kannan, Sankaranarayanan, Nolo, Riitta M., Hornbaker, Marisa, Chandra, Joya, Zweidler-McKay, Patrick A.
Publicado 2018

The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling

por Trinh, Bon Q., Barengo, Nicolas, Kim, Sang Bae, Lee, Ju-Seog, Zweidler-McKay, Patrick A., Naora, Honami
Publicado 2015

Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia

por Kuang, Shao-Qing, Fang, Zhihong, Zweidler-McKay, Patrick A., Yang, Hui, Wei, Yue, Gonzalez-Cervantes, Emilio A., Boumber, Yanis, Garcia-Manero, Guillermo
Publicado 2013

Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy

por Kannan, Sankaranarayan, Irwin, Mary E., Herbrich, Shelley M., Cheng, Tiewei, Patterson, LaNisha L., Aitken, Marisa J. L., Bhalla, Kapil, You, M. James, Konopleva, Marina, Zweidler-McKay, Patrick A., Chandra, Joya
Publicado 2022

Notch activation inhibits AML growth and survival: a potential therapeutic approach

por Kannan, Sankaranarayanan, Sutphin, Robert M., Hall, Mandy G., Golfman, Leonard S., Fang, Wendy, Nolo, Riitta M., Akers, Lauren J., Hammitt, Richard A., McMurray, John S., Kornblau, Steven M., Melnick, Ari M., Figueroa, Maria E., Zweidler-McKay, Patrick A.
Publicado 2013

CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia

por Angelova, Evgeniya, Audette, Charlene, Kovtun, Yelena, Daver, Naval, Wang, Sa A., Pierce, Sherry, Konoplev, Sergej N., Khogeer, Haitham, Jorgensen, Jeffrey L., Konopleva, Marina, Zweidler-McKay, Patrick A., Medeiros, L. Jeffrey, Kantarjian, Hagop M., Jabbour, Elias J., Khoury, Joseph D.
Publicado 2019

Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104

por Benito, Juliana, Shi, Yuexi, Szymanska, Barbara, Carol, Hernan, Boehm, Ingrid, Lu, Hongbo, Konoplev, Sergej, Fang, Wendy, Zweidler-McKay, Patrick A., Campana, Dario, Borthakur, Gautam, Bueso-Ramos, Carlos, Shpall, Elizabeth, Thomas, Deborah A., Jordan, Craig T., Kantarjian, Hagop, Wilson, William R., Lock, Richard, Andreeff, Michael, Konopleva, Marina
Publicado 2011

Replacing cyclophosphamide/cytarabine/mercaptopurine with cyclophosphamide/etoposide during consolidation/delayed intensification does not improve outcome for pediatric B-cell acut...

por Burke, Michael J., Salzer, Wanda L., Devidas, Meenakshi, Dai, Yunfeng, Gore, Lia, Hilden, Joanne M., Larsen, Eric, Rabin, Karen R., Zweidler-McKay, Patrick A., Borowitz, Michael J., Wood, Brent, Heerema, Nyla A., Carroll, Andrew J., Winick, Naomi, Carroll, William L., Raetz, Elizabeth A., Loh, Mignon L., Hunger, Stephen P.
Publicado 2019

Regulation of PI3K signaling in T cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD

por Yuan, Tian, Yang, Yaling, Chen, Jiayu, Li, Wenhui, Li, Wuping, Zhang, Qi, Mi, Yingchang, Goswami, Rashmi S., You, Jeffrey Q., Lin, Daniel, Qian, M. Diana, Calin, Steliana, Liang, Yong, Miranda, Roberto N., Calin, George A., Zhou, Xiaoyan, Ma, Li, Zweidler-McKay, Patrick A., Liu, Bin, Weng, Andrew P., Medeiros, L. Jeffrey, Zhang, Yizhuo, You, M. James
Publicado 2017

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199

por Benito, Juliana M., Godfrey, Laura, Kojima, Kensuke, Hogdal, Leah, Wunderlich, Mark, Geng, Huimin, Marzo, Isabel, Harutyunyan, Karine G., Golfman, Leonard, North, Phillip, Kerry, Jon, Ballabio, Erica, Chonghaile, Triona Ní, Gonzalo, Oscar, Qiu, Yihua, Jeremias, Irmela, Debose, LaKiesha, O’Brien, Eric, Ma, Helen, Zhou, Ping, Jacamo, Rodrigo, Park, Eugene, Coombes, Kevin R., Zhang, Nianxiang, Thomas, Deborah A., O’Brien, Susan, Kantarjian, Hagop M., Leverson, Joel D., Kornblau, Steven M., Andreeff, Michael, Müschen, Markus, Zweidler-McKay, Patrick A., Mulloy, James C., Letai, Anthony, Milne, Thomas A., Konopleva, Marina
Publicado 2015