The Cells of the Islets of Langerhans

por Da Silva Xavier, Gabriela
Publicado 2018

Editorial: The pancreatic islet – a multifaceted hub of inter-cellular communication

por Zhang, Quan, Huising, Mark O., Da Silva Xavier, Gabriela, Hauge-Evans, Astrid C.
Publicado 2023

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells

por da Silva Xavier, Gabriela, Sun, Gao, Qian, Qingwen, Rutter, Guy A., Leclerc, Isabelle
Publicado 2010

Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion

por Nguyen-Tu, Marie-Sophie, da Silva Xavier, Gabriela, Leclerc, Isabelle, Rutter, Guy A.
Publicado 2018

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

por Nguyen-Tu, Marie-Sophie, Martinez-Sanchez, Aida, Leclerc, Isabelle, Rutter, Guy A., da Silva Xavier, Gabriela
Publicado 2020

Animal Models of GWAS-Identified Type 2 Diabetes Genes

por da Silva Xavier, Gabriela, Bellomo, Elisa A., McGinty, James A., French, Paul M., Rutter, Guy A.
Publicado 2013

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice

por da Silva Xavier, Gabriela, Mondragon, Angeles, Mourougavelou, Vishnou, Cruciani-Guglielmacci, Céline, Denom, Jessica, Herrera, Pedro Luis, Magnan, Christophe, Rutter, Guy A.
Publicado 2017

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells

por da Silva Xavier, Gabriela, Loder, Merewyn K., McDonald, Angela, Tarasov, Andrei I., Carzaniga, Raffaella, Kronenberger, Katrin, Barg, Sebastian, Rutter, Guy A.
Publicado 2009

Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells

por Noordeen, Nafeesa A., Khera, Tarnjit K., Sun, Gao, Longbottom, E. Rebecca, Pullen, Timothy J., da Silva Xavier, Gabriela, Rutter, Guy A., Leclerc, Isabelle
Publicado 2010

Divergent Effects of Liraglutide, Exendin-4, and Sitagliptin on Beta-Cell Mass and Indicators of Pancreatitis in a Mouse Model of Hyperglycaemia

por Mondragon, Angeles, Davidsson, Daniel, Kyriakoudi, Styliana, Bertling, Annika, Gomes-Faria, Rosa, Cohen, Patrizia, Rothery, Stephen, Chabosseau, Pauline, Rutter, Guy A., da Silva Xavier, Gabriela
Publicado 2014

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization

por An, Rong, da Silva Xavier, Gabriela, Semplici, Francesca, Vakhshouri, Saharnaz, Hao, Huai-Xiang, Rutter, Jared, Pagano, Mario A., Meggio, Flavio, Pinna, Lorenzo A., Rutter, Guy A.
Publicado 2010

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

por Mitchell, Ryan K., Mondragon, Angeles, Chen, Lingling, Mcginty, James A., French, Paul M., Ferrer, Jorge, Thorens, Bernard, Hodson, David J., Rutter, Guy A., Da Silva Xavier, Gabriela
Publicado 2015

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)

por Meur, Gargi, Qian, Qingwen, da Silva Xavier, Gabriela, Pullen, Timothy J., Tsuboi, Takashi, McKinnon, Caroline, Fletcher, Laura, Tavaré, Jeremy M., Hughes, Stephen, Johnson, Paul, Rutter, Guy A.
Publicado 2011

Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish

por Davis, Samuel P. X., Kumar, Sunil, Alexandrov, Yuriy, Bhargava, Ajay, da Silva Xavier, Gabriela, Rutter, Guy A., Frankel, Paul, Sahai, Erik, Flaxman, Seth, French, Paul M. W., McGinty, James
Publicado 2019

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells

por Dominguez, Veronica, Raimondi, Claudio, Somanath, Sangeeta, Bugliani, Marco, Loder, Merewyn K., Edling, Charlotte E., Divecha, Nullin, da Silva-Xavier, Gabriela, Marselli, Lorella, Persaud, Shanta J., Turner, Mark D., Rutter, Guy A., Marchetti, Piero, Falasca, Marco, Maffucci, Tania
Publicado 2011

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity

por Kimura, Tomohiko, Obata, Atsushi, Shimoda, Masashi, Shimizu, Ikki, da Silva Xavier, Gabriela, Okauchi, Seizo, Hirukawa, Hidenori, Kohara, Kenji, Mune, Tomoatsu, Moriuchi, Saeko, Hiraoka, Arudo, Tamura, Kentaro, Chikazawa, Genta, Ishida, Atsuhisa, Yoshitaka, Hidenori, Rutter, Guy A., Kaku, Kohei, Kaneto, Hideaki
Publicado 2018

The pore-forming subunit MCU of the mitochondrial Ca(2+) uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

por Georgiadou, Eleni, Haythorne, Elizabeth, Dickerson, Matthew T., Lopez-Noriega, Livia, Pullen, Timothy J., da Silva Xavier, Gabriela, Davis, Samuel P. X., Martinez-Sanchez, Aida, Semplici, Francesca, Rizzuto, Rosario, McGinty, James A., French, Paul M., Cane, Matthew C., Jacobson, David A., Leclerc, Isabelle, Rutter, Guy A.
Publicado 2020

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

por Semplici, Francesca, Mondragon, Angeles, Macintyre, Benedict, Madeyski-Bengston, Katja, Persson-Kry, Anette, Barr, Sara, Ramne, Anna, Marley, Anna, McGinty, James, French, Paul, Soedling, Helen, Yokosuka, Ryohsuke, Gaitan, Julien, Lang, Jochen, Migrenne-Li, Stephanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, da Silva Xavier, Gabriela, Rutter, Guy A.
Publicado 2016

Neuronatin regulates pancreatic β cell insulin content and secretion

por Millership, Steven J., Da Silva Xavier, Gabriela, Choudhury, Agharul I., Bertazzo, Sergio, Chabosseau, Pauline, Pedroni, Silvia M.A., Irvine, Elaine E., Montoya, Alex, Faull, Peter, Taylor, William R., Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge, Christian, Mark, John, Rosalind M., Latreille, Mathieu, Liu, Ming, Rutter, Guy A., Scott, James, Withers, Dominic J.
Publicado 2018

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

por Viloria, Katrina, Nasteska, Daniela, Briant, Linford J.B., Heising, Silke, Larner, Dean P., Fine, Nicholas H.F., Ashford, Fiona B., da Silva Xavier, Gabriela, Ramos, Maria Jiménez, Hasib, Annie, Cuozzo, Federica, Manning Fox, Jocelyn E., MacDonald, Patrick E., Akerman, Ildem, Lavery, Gareth G., Flaxman, Christine, Morgan, Noel G., Richardson, Sarah J., Hewison, Martin, Hodson, David J.
Publicado 2020