Comparative modelling by restraint-based conformational sampling

por Furnham, Nicholas, de Bakker, Paul IW, Gore, Swanand, Burke, David F, Blundell, Tom L
Publicado 2008

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens

por Jia, Xiaoming, Han, Buhm, Onengut-Gumuscu, Suna, Chen, Wei-Min, Concannon, Patrick J., Rich, Stephen S., Raychaudhuri, Soumya, de Bakker, Paul I.W.
Publicado 2013

Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

por Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L., Trynka, Gosia, Hunt, Karen A., Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A., Wijmenga, Cisca, de Bakker, Paul I.W.
Publicado 2015

Next-generation sequencing for HLA typing of class I loci

por Erlich, Rachel L, Jia, Xiaoming, Anderson, Scott, Banks, Eric, Gao, Xiaojiang, Carrington, Mary, Gupta, Namrata, DePristo, Mark A, Henn, Matthew R, Lennon, Niall J, de Bakker, Paul IW
Publicado 2011

A framework for the detection of de novo mutations in family-based sequencing data

por Francioli, Laurent C, Cretu-Stancu, Mircea, Garimella, Kiran V, Fromer, Menachem, Kloosterman, Wigard P, Samocha, Kaitlin E, Neale, Benjamin M, Daly, Mark J, Banks, Eric, DePristo, Mark A, de Bakker, Paul IW
Publicado 2017

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

por Jablonski, Kathleen A., McAteer, Jarred B., de Bakker, Paul I.W., Franks, Paul W., Pollin, Toni I., Hanson, Robert L., Saxena, Richa, Fowler, Sarah, Shuldiner, Alan R., Knowler, William C., Altshuler, David, Florez, Jose C.
Publicado 2010

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

por Wang, Joanne H, Pappas, Derek, De Jager, Philip L, Pelletier, Daniel, de Bakker, Paul IW, Kappos, Ludwig, Polman, Chris H, Chibnik, Lori B, Hafler, David A, Matthews, Paul M, Hauser, Stephen L, Baranzini, Sergio E, Oksenberg, Jorge R
Publicado 2011

Amino Acid Position 11 of HLA-DRβ1 is a Major Determinant of Chromosome 6p Association with Ulcerative Colitis

por Achkar, Jean-Paul, Klei, Lambertus, de Bakker, Paul I.W., Bellone, Gaia, Rebert, Nancy, Scott, Regan, Lu, Ying, Regueiro, Miguel, Brzezinski, Aaron, Kamboh, M. Ilyas, Fiocchi, Claudio, Devlin, Bernie, Trucco, Massimo, Ringquist, Steven, Roeder, Kathryn, Duerr, Richard H
Publicado 2011

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

por Raychaudhuri, Soumya, Sandor, Cynthia, Stahl, Eli A., Freudenberg, Jan, Lee, Hye-Soon, Jia, Xiaoming, Alfredsson, Lars, Padyukov, Leonid, Klareskog, Lars, Worthington, Jane, Siminovitch, Katherine A., Bae, Sang-Cheol, Plenge, Robert M., Gregersen, Peter K., de Bakker, Paul I.W.
Publicado 2012

Classical HLA-DRB1 and DPB1 Alleles Account for HLA Associations with Primary Biliary Cirrhosis

por Invernizzi, Pietro, Ransom, Michael, Raychaudhuri, Soumya, Kosoy, Roman, Lleo, Ana, Shigeta, Russell, Franke, Andre, Bossa, Fabrizio, Amos, Christopher I., Gregersen, Peter K., Siminovitch, Katherine A., Cusi, Daniele, de Bakker, Paul I.W., Podda, Mauro, Gershwin, M. Eric, Seldin, Michael F.
Publicado 2012

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

por Li, Mingkun, Rothwell, Rebecca, Vermaat, Martijn, Wachsmuth, Manja, Schröder, Roland, Laros, Jeroen F.J., van Oven, Mannis, de Bakker, Paul I.W., Bovenberg, Jasper A., van Duijn, Cornelia M., van Ommen, Gert-Jan B., Slagboom, P. Eline, Swertz, Morris A., Wijmenga, Cisca, Kayser, Manfred, Boomsma, Dorret I., Zöllner, Sebastian, de Knijff, Peter, Stoneking, Mark
Publicado 2016

Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes

por Okada, Yukinori, Han, Buhm, Tsoi, Lam C., Stuart, Philip E., Ellinghaus, Eva, Tejasvi, Trilokraj, Chandran, Vinod, Pellett, Fawnda, Pollock, Remy, Bowcock, Anne M., Krueger, Gerald G., Weichenthal, Michael, Voorhees, John J., Rahman, Proton, Gregersen, Peter K., Franke, Andre, Nair, Rajan P., Abecasis, Gonçalo R., Gladman, Dafna D., Elder, James T., de Bakker, Paul I.W., Raychaudhuri, Soumya
Publicado 2014

Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques

por van der Laan, Sander W., Siemelink, Marten A., Haitjema, Saskia, Foroughi Asl, Hassan, Perisic, Ljubica, Mokry, Michal, van Setten, Jessica, Malik, Rainer, Dichgans, Martin, Worrall, Bradford B, Samani, Nilesh J, Schunkert, Heribert, Erdmann, Jeanette, Hedin, Ulf, Paulsson-Berne, Gabrielle, Björkegrenn, Johan L.M, de Borst, Gert J., Asselbergs, Folkert W, den Ruijter, Folkert W, de Bakker, Paul I.W, Pasterkamp, Gerard
Publicado 2018

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

por Lundby, Alicia, Rossin, Elizabeth J., Steffensen, Annette B., Rav Acha, Moshe, Newton-Cheh, Christopher, Pfeufer, Arne, Lynch, Stacey N., Olesen, Søren-Peter, Brunak, Søren, Ellinor, Patrick T., Jukema, J.Wouter, Trompet, Stella, Ford, Ian, Macfarlane, Peter W., Krijthe, Bouwe P., Hofman, Albert, Uitterlinden, Andre G., Stricker, Bruno H., Nathoe, Hendrik M., Spiering, Wilko, Daly, Mark J., Asselbergs, Folkert W., van der Harst, Pim, Milan, David J., de Bakker, Paul I.W., Lage, Kasper, Olsen, Jesper V.
Publicado 2014

Characteristics of de novo structural changes in the human genome

por Kloosterman, Wigard P., Francioli, Laurent C., Hormozdiari, Fereydoun, Marschall, Tobias, Hehir-Kwa, Jayne Y., Abdellaoui, Abdel, Lameijer, Eric-Wubbo, Moed, Matthijs H., Koval, Vyacheslav, Renkens, Ivo, van Roosmalen, Markus J., Arp, Pascal, Karssen, Lennart C., Coe, Bradley P., Handsaker, Robert E., Suchiman, Eka D., Cuppen, Edwin, Thung, Djie Tjwan, McVey, Mitch, Wendl, Michael C., Uitterlinden, André, van Duijn, Cornelia M., Swertz, Morris A., Wijmenga, Cisca, van Ommen, GertJan B., Slagboom, P. Eline, Boomsma, Dorret I., Schönhuth, Alexander, Eichler, Evan E., de Bakker, Paul I.W., Ye, Kai, Guryev, Victor
Publicado 2015

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

por Orho-Melander, Marju, Melander, Olle, Guiducci, Candace, Perez-Martinez, Pablo, Corella, Dolores, Roos, Charlotta, Tewhey, Ryan, Rieder, Mark J., Hall, Jennifer, Abecasis, Goncalo, Tai, E. Shyong, Welch, Cullan, Arnett, Donna K., Lyssenko, Valeriya, Lindholm, Eero, Saxena, Richa, de Bakker, Paul I.W., Burtt, Noel, Voight, Benjamin F., Hirschhorn, Joel N., Tucker, Katherine L., Hedner, Thomas, Tuomi, Tiinamaija, Isomaa, Bo, Eriksson, Karl-Fredrik, Taskinen, Marja-Riitta, Wahlstrand, Björn, Hughes, Thomas E., Parnell, Laurence D., Lai, Chao-Qiang, Berglund, Göran, Peltonen, Leena, Vartiainen, Erkki, Jousilahti, Pekka, Havulinna, Aki S., Salomaa, Veikko, Nilsson, Peter, Groop, Leif, Altshuler, David, Ordovas, Jose M., Kathiresan, Sekar
Publicado 2008

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

por Lenz, Tobias L., Deutsch, Aaron J., Han, Buhm, Hu, Xinli, Okada, Yukinori, Eyre, Stephen, Knapp, Michael, Zhernakova, Alexandra, Huizinga, Tom W.J., Abecasis, Goncalo, Becker, Jessica, Boeckxstaens, Guy E., Chen, Wei-Min, Franke, Andre, Gladman, Dafna D., Gockel, Ines, Gutierrez-Achury, Javier, Martin, Javier, Nair, Rajan P., Nöthen, Markus M., Onengut-Gumuscu, Suna, Rahman, Proton, Rantapää-Dahlqvist, Solbritt, Stuart, Philip E., Tsoi, Lam C., Van Heel, David A., Worthington, Jane, Wouters, Mira M., Klareskog, Lars, Elder, James T., Gregersen, Peter K., Schumacher, Johannes, Rich, Stephen S., Wijmenga, Cisca, Sunyaev, Shamil R., de Bakker, Paul I.W., Raychaudhuri, Soumya
Publicado 2015

High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

por Eyre, Steve, Bowes, John, Diogo, Dorothée, Lee, Annette, Barton, Anne, Martin, Paul, Zhernakova, Alexandra, Stahl, Eli, Viatte, Sebastien, McAllister, Kate, Amos, Christopher I., Padyukov, Leonid, Toes, Rene E.M., Huizinga, Tom W.J., Wijmenga, Cisca, Trynka, Gosia, Franke, Lude, Westra, Harm-Jan, Alfredsson, Lars, Hu, Xinli, Sandor, Cynthia, de Bakker, Paul I.W., Davila, Sonia, Khor, Chiea Chuen, Heng, Khai Koon, Andrews, Robert, Edkins, Sarah, Hunt, Sarah E, Langford, Cordelia, Symmons, Deborah, Concannon, Pat, Onengut-Gumuscu, Suna, Rich, Stephen S, Deloukas, Panos, Gonzalez-Gay, Miguel A., Rodriguez-Rodriguez, Luis, Ärlsetig, Lisbeth, Martin, Javier, Rantapää-Dahlqvist, Solbritt, Plenge, Robert, Raychaudhuri, Soumya, Klareskog, Lars, Gregersen, Peter K, Worthington, Jane
Publicado 2012

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

por Kilarski, Laura L., Achterberg, Sefanja, Devan, William J., Traylor, Matthew, Malik, Rainer, Lindgren, Arne, Pare, Guillame, Sharma, Pankaj, Slowik, Agniesczka, Thijs, Vincent, Walters, Matthew, Worrall, Bradford B., Sale, Michele M., Algra, Ale, Kappelle, L. Jaap, Wijmenga, Cisca, Norrving, Bo, Sandling, Johanna K., Rönnblom, Lars, Goris, An, Franke, Andre, Sudlow, Cathie, Rothwell, Peter M., Levi, Christopher, Holliday, Elizabeth G., Fornage, Myriam, Psaty, Bruce, Gretarsdottir, Solveig, Thorsteinsdottir, Unnar, Seshadri, Sudha, Mitchell, Braxton D., Kittner, Steven, Clarke, Robert, Hopewell, Jemma C., Bis, Joshua C., Boncoraglio, Giorgio B., Meschia, James, Ikram, M. Arfan, Hansen, Bjorn M., Montaner, Joan, Thorleifsson, Gudmar, Stefanson, Kari, Rosand, Jonathan, de Bakker, Paul I.W., Farrall, Martin, Dichgans, Martin, Markus, Hugh S., Bevan, Steve
Publicado 2014

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

por Cortes, Adrian, Pulit, Sara L., Leo, Paul J., Pointon, Jenny J., Robinson, Philip C., Weisman, Michael H., Ward, Michael, Gensler, Lianne S., Zhou, Xiaodong, Garchon, Henri-Jean, Chiocchia, Gilles, Nossent, Johannes, Lie, Benedicte A., Førre, Øystein, Tuomilehto, Jaakko, Laiho, Kari, Bradbury, Linda A., Elewaut, Dirk, Burgos-Vargas, Ruben, Stebbings, Simon, Appleton, Louise, Farrah, Claire, Lau, Jonathan, Haroon, Nigil, Mulero, Juan, Blanco, Francisco J., Gonzalez-Gay, Miguel A., Lopez-Larrea, C, Bowness, Paul, Gaffney, Karl, Gaston, Hill, Gladman, Dafna D., Rahman, Proton, Maksymowych, Walter P., Crusius, J. Bart A., van der Horst-Bruinsma, Irene E., Valle-Oñate, Raphael, Romero-Sánchez, Consuelo, Hansen, Inger Myrnes, Pimentel-Santos, Fernando M., Inman, Robert D., Martin, Javier, Breban, Maxime, Wordsworth, Bryan Paul, Reveille, John D., Evans, David M., de Bakker, Paul I.W., Brown, Matthew A.
Publicado 2015