Modulation of Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles

por Zhang, Boyan, Kuipers, Folkert, de Boer, Jan Freark, Kuivenhoven, Jan Albert
Publicado 2021

Response to Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH

por Ronda, Onne A.H.O., Bloks, Vincent W., De Boer, Jan-Freark, Kuipers, Folkert, Verkade, Henkjan J.
Publicado 2022

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Deficiency Reduces Insulin Sensitivity in High-Fat Diet-Fed Mice

por de Boer, Jan Freark, Dikkers, Arne, Jurdzinski, Angelika, von Felden, Johann, Gaestel, Matthias, Bavendiek, Udo, Tietge, Uwe J. F.
Publicado 2014

Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice

por Yang, Jiufang, van Dijk, Theo H., Koehorst, Martijn, Havinga, Rick, de Boer, Jan Freark, Kuipers, Folkert, van Zutphen, Tim
Publicado 2023

Group IIA Secretory Phospholipase A(2) Predicts Graft Failure and Mortality in Renal Transplant Recipients by Mediating Decreased Kidney Function

por Annema, Wijtske, de Boer, Jan Freark, Dikkers, Arne, Dimova, Lidiya G., van der Giet, Markus, Bakker, Stephan J.L., Tietge, Uwe J.F.
Publicado 2020

Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70(-/-) mice with human-like bile acids

por de Vries, Hilde D., Palmiotti, Anna, Li, Rumei, Hovingh, Milaine V., Mulder, Niels L., Koehorst, Martijn, Bloks, Vincent W., van Zutphen, Tim, Kuipers, Folkert, de Boer, Jan Freark
Publicado 2022

Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition

por Sjöland, Wilhelm, Wahlström, Annika, Makki, Kassem, Schöler, Marc, Molinaro, Antonio, Olsson, Lisa, Greiner, Thomas Uwe, Caesar, Robert, de Boer, Jan Freark, Kuipers, Folkert, Bäckhed, Fredrik, Marschall, Hanns-Ulrich
Publicado 2023

Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition

por Verkade, Esther, Shen, Wenqiang, Hovingh, Milaine V., Mulder, Niels L., de Bruyn, Krisztina, Koehorst, Martijn, de Vries, Hilde D., Bloks, Vincent W., Kuipers, Folkert, de Boer, Jan Freark
Publicado 2023

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice

por de Boer, Jan Freark, Verkade, Esther, Mulder, Niels L., de Vries, Hilde D., Huijkman, Nicolette, Koehorst, Martijn, Boer, Theo, Wolters, Justina C., Bloks, Vincent W., van de Sluis, Bart, Kuipers, Folkert
Publicado 2020

Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study

por Annema, Wijtske, Dikkers, Arne, de Boer, Jan Freark, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Stehouwer, Coen D. A., Dullaart, Robin P. F., Tietge, Uwe J. F.
Publicado 2016

Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70(−/−) mice by reducing fat absorption

por Li, Rumei, Palmiotti, Anna, de Vries, Hilde D., Hovingh, Milaine V., Koehorst, Martijn, Mulder, Niels L., Zhang, Yue, Kats, Kim, Bloks, Vincent W., Fu, Jingyuan, Verkade, Henkjan J., de Boer, Jan Freark, Kuipers, Folkert
Publicado 2021

Combined GIP receptor and GLP1 receptor agonism attenuates NAFLD in male APOE∗3-Leiden.CETP mice

por Ying, Zhixiong, van Eenige, Robin, Ge, Xiaoke, van Marwijk, Christy, Lambooij, Joost M., Guigas, Bruno, Giera, Martin, de Boer, Jan Freark, Coskun, Tamer, Qu, Hongchang, Wang, Yanan, Boon, Mariëtte R., Rensen, Patrick C.N., Kooijman, Sander
Publicado 2023

Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70(−/−) Mice with a Human-like Bile Acid Composition

por Palmiotti, Anna, de Vries, Hilde D., Hovingh, Milaine V., Koehorst, Martijn, Mulder, Niels L., Verkade, Esther, Veentjer, Melany K., van Dijk, Theo H., Bloks, Vincent W., Havinga, Rick, Verkade, Henkjan J., de Boer, Jan Freark, Kuipers, Folkert
Publicado 2023

High-resolution imaging of human atherosclerotic carotid plaques with micro(18)F-FDG PET scanning exploring plaque vulnerability

por Masteling, Marleen G., Zeebregts, Clark J., Tio, René A., Breek, Jan-Cees, Tietge, Uwe J. F., de Boer, Jan Freark, Glaudemans, Andor W. J. M., Dierckx, Rudi A. J. O., Boersma, Hendrikus H., Slart, Riemer H. J. A.
Publicado 2011

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

por Correia, Jorge C., Massart, Julie, de Boer, Jan Freark, Porsmyr-Palmertz, Margareta, Martínez-Redondo, Vicente, Agudelo, Leandro Z., Sinha, Indranil, Meierhofer, David, Ribeiro, Vera, Björnholm, Marie, Sauer, Sascha, Dahlman-Wright, Karin, Zierath, Juleen R., Groen, Albert K., Ruas, Jorge L.
Publicado 2015

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation

por Zhou, Enchen, Ge, Xiaoke, Nakashima, Hiroyuki, Li, Rumei, van der Zande, Hendrik J P, Liu, Cong, Li, Zhuang, Müller, Christoph, Bracher, Franz, Mohammed, Yassene, de Boer, Jan Freark, Kuipers, Folkert, Guigas, Bruno, Glass, Christopher K, Rensen, Patrick C N, Giera, Martin, Wang, Yanan
Publicado 2023

A Systems Analysis of Phenotype Heterogeneity in APOE*3Leiden.CETP Mice Induced by Long-Term High-Fat High-Cholesterol Diet Feeding

por Paalvast, Yared, Zhou, Enchen, Rozendaal, Yvonne J. W., Wang, Yanan, Gerding, Albert, van Dijk, Theo H., de Boer, Jan Freark, Rensen, Patrick C. N., van Dijk, Ko Willems, Kuivenhoven, Jan A., Bakker, Barbara M., van Riel, Natal A. W., Groen, Albert K.
Publicado 2022

Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice

por Hoogerland, Joanne A., Lei, Yu, Wolters, Justina C., de Boer, Jan Freark, Bos, Trijnie, Bleeker, Aycha, Mulder, Niels L., van Dijk, Theo H., Kuivenhoven, Jan A., Rajas, Fabienne, Mithieux, Gilles, Haeusler, Rebecca A., Verkade, Henkjan J., Bloks, Vincent W., Kuipers, Folkert, Oosterveer, Maaike H.
Publicado 2019

Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid

por de Boer, Jan Freark, de Vries, Hilde D., Palmiotti, Anna, Li, Rumei, Doestzada, Marwah, Hoogerland, Joanne A., Fu, Jingyuan, La Rose, Anouk M., Westerterp, Marit, Mulder, Niels L., Hovingh, Milaine V., Koehorst, Martijn, Kloosterhuis, Niels J., Wolters, Justina C., Bloks, Vincent W., Haas, Joel T., Dombrowicz, David, Staels, Bart, van de Sluis, Bart, Kuipers, Folkert
Publicado 2020