RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

por Wilkinson, Adam C., Ballabio, Erica, Geng, Huimin, North, Phillip, Tapia, Marta, Kerry, Jon, Biswas, Debabrata, Roeder, Robert G., Allis, C. David, Melnick, Ari, de Bruijn, Marella F.T.R., Milne, Thomas A.
Publicado 2013

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes

por Harman, Joe R., Thorne, Ross, Jamilly, Max, Tapia, Marta, Crump, Nicholas T., Rice, Siobhan, Beveridge, Ryan, Morrissey, Edward, de Bruijn, Marella F.T.R., Roberts, Irene, Roy, Anindita, Fulga, Tudor A., Milne, Thomas A.
Publicado 2021

Microhomologies are prevalent at Cas9-induced larger deletions

por Owens, Dominic D G, Caulder, Adam, Frontera, Vincent, Harman, Joe R, Allan, Alasdair J, Bucakci, Akin, Greder, Lucas, Codner, Gemma F, Hublitz, Philip, McHugh, Peter J, Teboul, Lydia, de Bruijn, Marella F T R
Publicado 2019

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

por Neo, Wen Hao, Meng, Yiran, Rodriguez-Meira, Alba, Fadlullah, Muhammad Z. H., Booth, Christopher A. G., Azzoni, Emanuele, Thongjuea, Supat, de Bruijn, Marella F. T. R., Jacobsen, Sten Eirik W., Mead, Adam J., Lacaud, Georges
Publicado 2021

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

por Owens, Dominic D. G., Anselmi, Giorgio, Oudelaar, A. Marieke, Downes, Damien J., Cavallo, Alessandro, Harman, Joe R., Schwessinger, Ron, Bucakci, Akin, Greder, Lucas, de Ornellas, Sara, Jeziorska, Danuta, Telenius, Jelena, Hughes, Jim R., de Bruijn, Marella F. T. R.
Publicado 2022

GATA2 mitotic bookmarking is required for definitive haematopoiesis

por Silvério-Alves, Rita, Kurochkin, Ilia, Rydström, Anna, Vazquez Echegaray, Camila, Haider, Jakob, Nicholls, Matthew, Rode, Christina, Thelaus, Louise, Lindgren, Aida Yifter, Ferreira, Alexandra Gabriela, Brandão, Rafael, Larsson, Jonas, de Bruijn, Marella F. T. R., Martin-Gonzalez, Javier, Pereira, Carlos-Filipe
Publicado 2023

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification

por Wilkinson, Adam C., Kawata, Viviane K. S., Schütte, Judith, Gao, Xuefei, Antoniou, Stella, Baumann, Claudia, Woodhouse, Steven, Hannah, Rebecca, Tanaka, Yosuke, Swiers, Gemma, Moignard, Victoria, Fisher, Jasmin, Hidetoshi, Shimauchi, Tijssen, Marloes R., de Bruijn, Marella F. T. R., Liu, Pentao, Göttgens, Berthold
Publicado 2014

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

por Azzoni, Emanuele, Frontera, Vincent, Anselmi, Giorgio, Rode, Christina, James, Chela, Deltcheva, Elitza M., Demian, Atanasiu S., Brown, John, Barone, Cristiana, Patelli, Arianna, Harman, Joe R., Nicholls, Matthew, Conway, Simon J., Morrissey, Edward, Jacobsen, Sten Eirik W., Sparrow, Duncan B., Harris, Adrian L., Enver, Tariq, de Bruijn, Marella F.T.R.
Publicado 2021

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

por Muskens, Ivo S., Li, Shaobo, Jackson, Thomas, Elliot, Natalina, Hansen, Helen M., Myint, Swe Swe, Pandey, Priyatama, Schraw, Jeremy M., Roy, Ritu, Anguiano, Joaquin, Goudevenou, Katerina, Siegmund, Kimberly D., Lupo, Philip J., de Bruijn, Marella F. T. R., Walsh, Kyle M., Vyas, Paresh, Ma, Xiaomei, Roy, Anindita, Roberts, Irene, Wiemels, Joseph L., de Smith, Adam J.
Publicado 2021