Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications

por de Bruin, Elza C, Taylor, Tiffany B, Swanton, Charles
Publicado 2013

Analysis of intratumor heterogeneity unravels lung cancer evolution

por de Bruin, Elza C, McGranahan, Nicholas, Swanton, Charles
Publicado 2015

Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

por Hiley, Crispin, de Bruin, Elza C, McGranahan, Nicholas, Swanton, Charles
Publicado 2014

Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition

por Vaclova, Tereza, Chakraborty, Atanu, Sherwood, James, Ross, Sarah, Carroll, Danielle, Barrett, J. Carl, Downward, Julian, de Bruin, Elza C.
Publicado 2022

Accurate detection of low prevalence AKT1 E17K mutation in tissue or plasma from advanced cancer patients

por de Bruin, Elza C., Whiteley, Jessica L., Corcoran, Claire, Kirk, Pauline M., Fox, Jayne C., Armisen, Javier, Lindemann, Justin P. O., Schiavon, Gaia, Ambrose, Helen J., Kohlmann, Alexander
Publicado 2017

Gene expression profiling reveals two separate mechanisms regulating apoptosis in rectal carcinomas in vivo

por de Bruin, Elza C., van de Pas, Simone, van de Velde, Cornelis J. H., van Krieken, J. Han J. M., Peltenburg, Lucy T. C., Marijnen, Corrie A. M., Medema, Jan Paul
Publicado 2007

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

por Vaclova, Tereza, Grazini, Ursula, Ward, Lewis, O’Neill, Daniel, Markovets, Aleksandra, Huang, Xiangning, Chmielecki, Juliann, Hartmaier, Ryan, Thress, Kenneth S., Smith, Paul D., Barrett, J. Carl, Downward, Julian, de Bruin, Elza C.
Publicado 2021

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer

por Li, Hongde, Stokes, William, Chater, Emily, Roy, Rajat, de Bruin, Elza, Hu, Yili, Liu, Zhigang, Smit, Egbert F, Heynen, Guus JJE, Downward, Julian, Seckl, Michael J, Wang, Yulan, Tang, Huiru, Pardo, Olivier E
Publicado 2016

Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION...

por Howell, Sacha J, Casbard, Angela, Carucci, Margherita, Ingarfield, Kate, Butler, Rachel, Morgan, Sian, Meissner, Magdalena, Bale, Catherine, Bezecny, Pavel, Moon, Sarah, Twelves, Chris, Venkitaraman, Ramachandran, Waters, Simon, de Bruin, Elza C, Schiavon, Gaia, Foxley, Andrew, Jones, Robert H
Publicado 2022

Clinical impact of HLA class I expression in rectal cancer

por Speetjens, Frank M., de Bruin, Elza C., Morreau, Hans, Zeestraten, Eliane C. M., Putter, Hein, van Krieken, J. Han, van Buren, Maaike M., van Velzen, Monique, Dekker-Ensink, N. Geeske, van de Velde, Cornelis J. H., Kuppen, Peter J. K.
Publicado 2007

Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles

por de Bruin, Elza C, van de Pas, Simone, Lips, Esther H, van Eijk, Ronald, van der Zee, Minke MC, Lombaerts, Marcel, van Wezel, Tom, Marijnen, Corrie AM, van Krieken, J Han JM, Medema, Jan Paul, van de Velde, Cornelis JH, Eilers, Paul HC, Peltenburg, Lucy TC
Publicado 2005

Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models

por Hopcroft, Lorna, Wigmore, Eleanor M., Williamson, Stuart C., Ros, Susana, Eberlein, Cath, Moss, Jennifer I., Urosevic, Jelena, Carnevalli, Larissa S., Talbot, Sara, Bradshaw, Lauren, Blaker, Catherine, Gunda, Sreeharsha, Owenson, Venetia, Hoffmann, Scott, Sutton, Daniel, Jones, Stewart, Goodwin, Richard J. A., Willis, Brandon S., Rooney, Claire, de Bruin, Elza C., Barry, Simon T.
Publicado 2023

Author Correction: Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models

por Hopcroft, Lorna, Wigmore, Eleanor M., Williamson, Stuart C., Ros, Susana, Eberlein, Cath, Moss, Jennifer I., Urosevic, Jelena, Carnevalli, Larissa S., Talbot, Sara, Bradshaw, Lauren, Blaker, Catherine, Gunda, Sreeharsha, Owenson, Venetia, Hoffmann, Scott, Sutton, Daniel, Jones, Stewart, Goodwin, Richard J. A., Willis, Brandon S., Rooney, Claire, DeBruin, Elza, Barry, Simon T.
Publicado 2023

Author Correction: Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models

por Hopcroft, Lorna, Wigmore, Eleanor M., Williamson, Stuart C., Ros, Susana, Eberlein, Cath, Moss, Jennifer I., Urosevic, Jelena, Carnevalli, Larissa S., Talbot, Sara, Bradshaw, Lauren, Blaker, Catherine, Gunda, Sreeharsha, Owenson, Venetia, Hoffmann, Scott, Sutton, Daniel, Jones, Stewart, Goodwin, Richard J. A., Willis, Brandon S., Rooney, Claire, de Bruin, Elza C., Barry, Simon T.
Publicado 2023

Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer

por Smyth, Lillian M., Batist, Gerald, Meric-Bernstam, Funda, Kabos, Peter, Spanggaard, Iben, Lluch, Ana, Jhaveri, Komal, Varga, Andrea, Wong, Andrea, Schram, Alison M., Ambrose, Helen, Carr, T. Hedley, de Bruin, Elza C., Salinas-Souza, Carolina, Foxley, Andrew, Hauser, Joana, Lindemann, Justin P. O., Maudsley, Rhiannon, McEwen, Robert, Moschetta, Michele, Nikolaou, Myria, Schiavon, Gaia, Razavi, Pedram, Banerji, Udai, Baselga, José, Hyman, David M., Chandarlapaty, Sarat
Publicado 2021

A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

por Choudhury, Atish D., Higano, Celestia S., de Bono, Johann S., Cook, Natalie, Rathkopf, Dana E., Wisinski, Kari B., Martin-Liberal, Juan, Linch, Mark, Heath, Elisabeth I., Baird, Richard D., García-Carbacho, Javier, Quintela-Fandino, Miguel, Barry, Simon T., de Bruin, Elza C., Colebrook, Steve, Hawkins, George, Klinowska, Teresa, Maroj, Brijesh, Moorthy, Ganesh, Mortimer, Peter G., Moschetta, Michele, Nikolaou, Myria, Sainsbury, Liz, Shapiro, Geoffrey I., Siu, Lillian L., Hansen, Aaron R.
Publicado 2022

Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

por Fisher, Rosalie, Horswell, Stuart, Rowan, Andrew, Salm, Maximilian P, de Bruin, Elza C, Gulati, Sakshi, McGranahan, Nicholas, Stares, Mark, Gerlinger, Marco, Varela, Ignacio, Crockford, Andrew, Favero, Francesco, Quidville, Virginie, André, Fabrice, Navas, Carolina, Grönroos, Eva, Nicol, David, Hazell, Steve, Hrouda, David, O’Brien, Tim, Matthews, Nik, Phillimore, Ben, Begum, Sharmin, Rabinowitz, Adam, Biggs, Jennifer, Bates, Paul A, McDonald, Neil Q, Stamp, Gordon, Spencer-Dene, Bradley, Hsieh, James J, Xu, Jianing, Pickering, Lisa, Gore, Martin, Larkin, James, Swanton, Charles
Publicado 2014

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

por Kovac, Michal, Navas, Carolina, Horswell, Stuart, Salm, Max, Bardella, Chiara, Rowan, Andrew, Stares, Mark, Castro-Giner, Francesc, Fisher, Rosalie, de Bruin, Elza C., Kovacova, Monika, Gorman, Maggie, Makino, Seiko, Williams, Jennet, Jaeger, Emma, Jones, Angela, Howarth, Kimberley, Larkin, James, Pickering, Lisa, Gore, Martin, Nicol, David L., Hazell, Steven, Stamp, Gordon, O’Brien, Tim, Challacombe, Ben, Matthews, Nik, Phillimore, Benjamin, Begum, Sharmin, Rabinowitz, Adam, Varela, Ignacio, Chandra, Ashish, Horsfield, Catherine, Polson, Alexander, Tran, Maxine, Bhatt, Rupesh, Terracciano, Luigi, Eppenberger-Castori, Serenella, Protheroe, Andrew, Maher, Eamonn, El Bahrawy, Mona, Fleming, Stewart, Ratcliffe, Peter, Heinimann, Karl, Swanton, Charles, Tomlinson, Ian
Publicado 2015

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

por Jamal-Hanjani, Mariam, Hackshaw, Alan, Ngai, Yenting, Shaw, Jacqueline, Dive, Caroline, Quezada, Sergio, Middleton, Gary, de Bruin, Elza, Le Quesne, John, Shafi, Seema, Falzon, Mary, Horswell, Stuart, Blackhall, Fiona, Khan, Iftekhar, Janes, Sam, Nicolson, Marianne, Lawrence, David, Forster, Martin, Fennell, Dean, Lee, Siow-Ming, Lester, Jason, Kerr, Keith, Muller, Salli, Iles, Natasha, Smith, Sean, Murugaesu, Nirupa, Mitter, Richard, Salm, Max, Stuart, Aengus, Matthews, Nik, Adams, Haydn, Ahmad, Tanya, Attanoos, Richard, Bennett, Jonathan, Birkbak, Nicolai Juul, Booton, Richard, Brady, Ged, Buchan, Keith, Capitano, Arrigo, Chetty, Mahendran, Cobbold, Mark, Crosbie, Philip, Davies, Helen, Denison, Alan, Djearman, Madhav, Goldman, Jacki, Haswell, Tom, Joseph, Leena, Kornaszewska, Malgorzata, Krebs, Matthew, Langman, Gerald, MacKenzie, Mairead, Millar, Joy, Morgan, Bruno, Naidu, Babu, Nonaka, Daisuke, Peggs, Karl, Pritchard, Catrin, Remmen, Hardy, Rowan, Andrew, Shah, Rajesh, Smith, Elaine, Summers, Yvonne, Taylor, Magali, Veeriah, Selvaraju, Waller, David, Wilcox, Ben, Wilcox, Maggie, Woolhouse, Ian, McGranahan, Nicholas, Swanton, Charles
Publicado 2014