A cVLP-Based Vaccine Displaying Full-Length PCSK9 Elicits a Higher Reduction in Plasma PCSK9 Than Similar Peptide-Based cVLP Vaccines

por Goksøyr, Louise, Skrzypczak, Magdalena, Sampson, Maureen, Nielsen, Morten A., Salanti, Ali, Theander, Thor G., Remaley, Alan T., De Jongh, Willem A., Sander, Adam F.
Publicado 2022

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

por Wright, Katherine E., Hjerrild, Kathryn A., Bartlett, Jonathan, Douglas, Alexander D., Jin, Jing, Brown, Rebecca E., Illingworth, Joseph J., Ashfield, Rebecca, Clemmensen, Stine B., de Jongh, Willem A., Draper, Simon J., Higgins, Matthew K.
Publicado 2014

FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in Drosophila S2 Cells

por Coker, Jesse A., Katis, Vittorio L., Fairhead, Michael, Schwenzer, Anja, Clemmensen, Stine B., Frandsen, Bent U., de Jongh, Willem A., Gileadi, Opher, Burgess-Brown, Nicola A., Marsden, Brian D., Midwood, Kim S., Yue, Wyatt W.
Publicado 2022

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

por Lennartz, Frank, Brod, Florian, Dabbs, Rebecca, Miura, Kazutoyo, Mekhaiel, David, Marini, Arianna, Jore, Matthijs M., Søgaard, Max M., Jørgensen, Thomas, de Jongh, Willem A., Sauerwein, Robert W., Long, Carole A., Biswas, Sumi, Higgins, Matthew K.
Publicado 2018

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

por Healer, Julie, Wong, Wilson, Thompson, Jennifer K., He, Wengqiang, Birkinshaw, Richard W., Miura, Kazutoyo, Long, Carol A., Soroka, Vladislav, Søgaard, Teit Max Moscote, Jørgensen, Thomas, de Jongh, Willem A., Weir, Christopher, Svahn, Ella, Czabotar, Peter E., Tham, Wai‐Hong, Mueller, Ivo, Barlow, Paul N., Cowman, Alan F.
Publicado 2019

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccin...

por Nielsen, Morten A., Resende, Mafalda, de Jongh, Willem A., Ditlev, Sisse B., Mordmüller, Benjamin, Houard, Sophie, Ndam, Nicaise Tuikue, Agerbæk, Mette Ø., Hamborg, Mette, Massougbodji, Achille, Issifou, Saddou, Strøbæk, Anette, Poulsen, Lars, Leroy, Odile, Kremsner, Peter G., Chippaux, Jean-Philippe, Luty, Adrian J. F., Deloron, Philippe, Theander, Thor G., Dyring, Charlotte, Salanti, Ali
Publicado 2015

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

por Hjerrild, Kathryn A., Jin, Jing, Wright, Katherine E., Brown, Rebecca E., Marshall, Jennifer M., Labbé, Geneviève M., Silk, Sarah E., Cherry, Catherine J., Clemmensen, Stine B., Jørgensen, Thomas, Illingworth, Joseph J., Alanine, Daniel G. W., Milne, Kathryn H., Ashfield, Rebecca, de Jongh, Willem A., Douglas, Alexander D., Higgins, Matthew K., Draper, Simon J.
Publicado 2016

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’

por Jin, Jing, Hjerrild, Kathryn A., Silk, Sarah E., Brown, Rebecca E., Labbé, Geneviève M., Marshall, Jennifer M., Wright, Katherine E., Bezemer, Sandra, Clemmensen, Stine B., Biswas, Sumi, Li, Yuanyuan, El-Turabi, Aadil, Douglas, Alexander D., Hermans, Pim, Detmers, Frank J., de Jongh, Willem A., Higgins, Matthew K., Ashfield, Rebecca, Draper, Simon J.
Publicado 2017

First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria

por Mordmüller, Benjamin, Sulyok, Mihály, Egger-Adam, Diane, Resende, Mafalda, de Jongh, Willem A, Jensen, Mette H, Smedegaard, Helle Holm, Ditlev, Sisse B, Soegaard, Max, Poulsen, Lars, Dyring, Charlotte, Calle, Carlos Lamsfus, Knoblich, Annette, Ibáñez, Javier, Esen, Meral, Deloron, Philippe, Ndam, Nicaise, Issifou, Saadou, Houard, Sophie, Howard, Randall F, Reed, Steven G, Leroy, Odile, Luty, Adrian J F, Theander, Thor G, Kremsner, Peter G, Salanti, Ali, Nielsen, Morten A
Publicado 2019

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

por Smit, Merel J, Sander, Adam F, Ariaans, Maud B P A, Fougeroux, Cyrielle, Heinzel, Constanze, Fendel, Rolf, Esen, Meral, Kremsner, Peter G, ter Heine, Rob, Wertheim, Heiman F, Idorn, Manja, Paludan, Søren Riis, Underwood, Alexander P, Binderup, Alekxander, Ramirez, Santseharay, Bukh, Jens, Soegaard, Max, Erdogan, Sayit M, Gustavsson, Tobias, Clemmensen, Stine, Theander, Thor G, Salanti, Ali, Hamborg, Mette, de Jongh, Willem A, McCall, Matthew B B, Nielsen, Morten A, Mordmüller, Benjamin G
Publicado 2023

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies

por Payne, Ruth O., Silk, Sarah E., Elias, Sean C., Milne, Kathryn H., Rawlinson, Thomas A., Llewellyn, David, Shakri, A. Rushdi, Jin, Jing, Labbé, Geneviève M., Edwards, Nick J., Poulton, Ian D., Roberts, Rachel, Farid, Ryan, Jørgensen, Thomas, Alanine, Daniel G.W., de Cassan, Simone C., Higgins, Matthew K., Otto, Thomas D., McCarthy, James S., de Jongh, Willem A., Nicosia, Alfredo, Moyle, Sarah, Hill, Adrian V.S., Berrie, Eleanor, Chitnis, Chetan E., Lawrie, Alison M., Draper, Simon J.
Publicado 2017

Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells

por Jin, Jing, Tarrant, Richard D., Bolam, Emma J., Angell-Manning, Philip, Soegaard, Max, Pattinson, David J., Dulal, Pawan, Silk, Sarah E., Marshall, Jennifer M., Dabbs, Rebecca A., Nugent, Fay L., Barrett, Jordan R., Hjerrild, Kathryn A., Poulsen, Lars, Jørgensen, Thomas, Brenner, Tanja, Baleanu, Ioana N., Parracho, Helena M., Tahiri-Alaoui, Abdessamad, Whale, Gary, Moyle, Sarah, Payne, Ruth O., Minassian, Angela M., Higgins, Matthew K., Detmers, Frank J., Lawrie, Alison M., Douglas, Alexander D., Smith, Robert, de Jongh, Willem A., Berrie, Eleanor, Ashfield, Rebecca, Draper, Simon J.
Publicado 2018

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

por Alanine, Daniel G.W., Quinkert, Doris, Kumarasingha, Rasika, Mehmood, Shahid, Donnellan, Francesca R., Minkah, Nana K., Dadonaite, Bernadeta, Diouf, Ababacar, Galaway, Francis, Silk, Sarah E., Jamwal, Abhishek, Marshall, Jennifer M., Miura, Kazutoyo, Foquet, Lander, Elias, Sean C., Labbé, Geneviève M., Douglas, Alexander D., Jin, Jing, Payne, Ruth O., Illingworth, Joseph J., Pattinson, David J., Pulido, David, Williams, Barnabas G., de Jongh, Willem A., Wright, Gavin J., Kappe, Stefan H.I., Robinson, Carol V., Long, Carole A., Crabb, Brendan S., Gilson, Paul R., Higgins, Matthew K., Draper, Simon J.
Publicado 2019

Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination

por Minassian, Angela M., Silk, Sarah E., Barrett, Jordan R., Nielsen, Carolyn M., Miura, Kazutoyo, Diouf, Ababacar, Loos, Carolin, Fallon, Jonathan K., Michell, Ashlin R., White, Michael T., Edwards, Nick J., Poulton, Ian D., Mitton, Celia H., Payne, Ruth O., Marks, Michael, Maxwell-Scott, Hector, Querol-Rubiera, Antonio, Bisnauthsing, Karen, Batra, Rahul, Ogrina, Tatiana, Brendish, Nathan J., Themistocleous, Yrene, Rawlinson, Thomas A., Ellis, Katherine J., Quinkert, Doris, Baker, Megan, Lopez Ramon, Raquel, Ramos Lopez, Fernando, Barfod, Lea, Folegatti, Pedro M., Silman, Daniel, Datoo, Mehreen, Taylor, Iona J., Jin, Jing, Pulido, David, Douglas, Alexander D., de Jongh, Willem A., Smith, Robert, Berrie, Eleanor, Noe, Amy R., Diggs, Carter L., Soisson, Lorraine A., Ashfield, Rebecca, Faust, Saul N., Goodman, Anna L., Lawrie, Alison M., Nugent, Fay L., Alter, Galit, Long, Carole A., Draper, Simon J.
Publicado 2021