Wnt Signaling in Cancer Stem Cell Biology

por de Sousa e Melo, Felipe, Vermeulen, Louis
Publicado 2016

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon

por Prasetyanti, Pramudita Ramadhina, Zimberlin, Cheryl Doreen, Bots, Michael, Vermeulen, Louis, De Sousa E Melo, Felipe, Medema, Jan Paul
Publicado 2013

Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis

por de Jong, Joan H., Rodermond, Hans M., Zimberlin, Cheryl D., Lascano, Valeria, De Sousa E Melo, Felipe, Richel, Dick J., Medema, Jan Paul, Vermeulen, Louis
Publicado 2012

Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

por Hansen, Simon, Zhang, Yingnan, Hwang, Sunhee, Nabhan, Ahmad, Li, Wanqing, Fuhrmann, Jakob, Kschonsak, Yvonne, Zhou, Lijuan, Nile, Aaron H., Gao, Xinxin, Piskol, Robert, de Sousa e Melo, Felipe, de Sauvage, Frederic J., Hannoush, Rami N.
Publicado 2022

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

por Fessler, Evelyn, Drost, Jarno, van Hooff, Sander R, Linnekamp, Janneke F, Wang, Xin, Jansen, Marnix, De Sousa E Melo, Felipe, Prasetyanti, Pramudita R, IJspeert, Joep EG, Franitza, Marek, Nürnberg, Peter, van Noesel, Carel JM, Dekker, Evelien, Vermeulen, Louis, Clevers, Hans, Medema, Jan Paul
Publicado 2016

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

por Schuijt, Tim J, Lankelma, Jacqueline M, Scicluna, Brendon P, de Sousa e Melo, Felipe, Roelofs, Joris J T H, de Boer, J Daan, Hoogendijk, Arjan J, de Beer, Regina, de Vos, Alex, Belzer, Clara, de Vos, Willem M, van der Poll, Tom, Wiersinga, W Joost
Publicado 2016

ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer

por Johnson, Radia M., Qu, Xueping, Lin, Chu-Fang, Huw, Ling-Yuh, Venkatanarayan, Avinashnarayan, Sokol, Ethan, Ou, Fang-Shu, Ihuegbu, Nnamdi, Zill, Oliver A., Kabbarah, Omar, Wang, Lisa, Bourgon, Richard, de Sousa e Melo, Felipe, Bolen, Chris, Daemen, Anneleen, Venook, Alan P., Innocenti, Federico, Lenz, Heinz-Josef, Bais, Carlos
Publicado 2022

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

por Taraborrelli, Lucia, Şenbabaoğlu, Yasin, Wang, Lifen, Lim, Junghyun, Blake, Kerrigan, Kljavin, Noelyn, Gierke, Sarah, Scherl, Alexis, Ziai, James, McNamara, Erin, Owyong, Mark, Rao, Shilpa, Calviello, Aslihan Karabacak, Oreper, Daniel, Jhunjhunwala, Suchit, Argiles, Guillem, Bendell, Johanna, Kim, Tae Won, Ciardiello, Fortunato, Wongchenko, Matthew J., de Sauvage, Frederic J., de Sousa e Melo, Felipe, Yan, Yibing, West, Nathaniel R., Murthy, Aditya
Publicado 2023

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

por Lenos, Kristiaan J, Miedema, Daniël M, Lodestijn, Sophie C, Nijman, Lisanne E, van den Bosch, Tom, Romero Ros, Xavier, Lourenço, Filipe C, Lecca, Maria C, van der Heijden, Maartje, van Neerven, Sanne M, van Oort, Anita, Leveille, Nicolas, Adam, Ronja S, de Sousa E Melo, Felipe, Otten, Joy, Veerman, Patrick, Hypolite, Guillaume, Koens, Lianne, Lyons, Scott K, Stassi, Giorgio, Winton, Douglas J, Medema, Jan Paul, Morrissey, Edward, Bijlsma, Maarten F, Vermeulen, Louis
Publicado 2018

The Consensus Molecular Subtypes of Colorectal Cancer

por Guinney, Justin, Dienstmann, Rodrigo, Wang, Xin, de Reyniès, Aurélien, Schlicker, Andreas, Soneson, Charlotte, Marisa, Laetitia, Roepman, Paul, Nyamundanda, Gift, Angelino, Paolo, Bot, Brian M., Morris, Jeffrey S., Simon, Iris M., Gerster, Sarah, Fessler, Evelyn, de Sousa e Melo, Felipe, Missiaglia, Edoardo, Ramay, Hena, Barras, David, Homicsko, Krisztian, Maru, Dipen, Manyam, Ganiraju C., Broom, Bradley, Boige, Valerie, Perez-Villamil, Beatriz, Laderas, Ted, Salazar, Ramon, Gray, Joe W., Hanahan, Douglas, Tabernero, Josep, Bernards, Rene, Friend, Stephen H., Laurent-Puig, Pierre, Medema, Jan Paul, Sadanandam, Anguraj, Wessels, Lodewyk, Delorenzi, Mauro, Kopetz, Scott, Vermeulen, Louis, Tejpar, Sabine
Publicado 2015

Antibody targeting of E3 ubiquitin ligases for receptor degradation

por Marei, Hadir, Tsai, Wen-Ting K., Kee, Yee-Seir, Ruiz, Karen, He, Jieyan, Cox, Chris, Sun, Tao, Penikalapati, Sai, Dwivedi, Pankaj, Choi, Meena, Kan, David, Saenz-Lopez, Pablo, Dorighi, Kristel, Zhang, Pamela, Kschonsak, Yvonne T., Kljavin, Noelyn, Amin, Dhara, Kim, Ingrid, Mancini, Andrew G., Nguyen, Thao, Wang, Chunling, Janezic, Eric, Doan, Alexander, Mai, Elaine, Xi, Hongkang, Gu, Chen, Heinlein, Melanie, Biehs, Brian, Wu, Jia, Lehoux, Isabelle, Harris, Seth, Comps-Agrar, Laetitia, Seshasayee, Dhaya, de Sauvage, Frederic J., Grimmer, Matthew, Li, Jing, Agard, Nicholas J., de Sousa e Melo, Felipe
Publicado 2022