Molecular Dynamics of CYP2D6 Polymorphisms in the Absence and Presence of a Mechanism-Based Inactivator Reveals Changes in Local Flexibility and Dominant Substrate Access Channels

por de Waal, Parker W., Sunden, Kyle F., Furge, Laura Lowe
Publicado 2014

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

por de Waal, Parker W., Shi, Jingjing, You, Erli, Wang, Xiaoxi, Melcher, Karsten, Jiang, Yi, Xu, H. Eric, Dickson, Bradley M.
Publicado 2020

Structural mechanism of a drug-binding process involving a large conformational change of the protein target

por Ayaz, Pelin, Lyczek, Agatha, Paung, YiTing, Mingione, Victoria R., Iacob, Roxana E., de Waal, Parker W., Engen, John R., Seeliger, Markus A., Shan, Yibing, Shaw, David E.
Publicado 2023

Structural basis of AMPK regulation by adenine nucleotides and glycogen

por Li, Xiaodan, Wang, Lili, Zhou, X Edward, Ke, Jiyuan, de Waal, Parker W, Gu, Xin, Tan, M H Eileen, Wang, Dongye, Wu, Donghai, Xu, H Eric, Melcher, Karsten
Publicado 2015

The structural basis of the dominant negative phenotype of the Gα(i1)β(1)γ(2) G203A/A326S heterotrimer

por Liu, Ping, Jia, Ming-zhu, Zhou, X Edward, De Waal, Parker W, Dickson, Bradley M, Liu, Bo, Hou, Li, Yin, Yan-ting, Kang, Yan-yong, Shi, Yi, Melcher, Karsten, Xu, H Eric, Jiang, Yi
Publicado 2016

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

por Gu, Xin, Yan, Yan, Novick, Scott J., Kovach, Amanda, Goswami, Devrishi, Ke, Jiyuan, Tan, M. H. Eileen, Wang, Lili, Li, Xiaodan, de Waal, Parker W., Webb, Martin R., Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten
Publicado 2017

Structure of formylpeptide receptor 2-G(i) complex reveals insights into ligand recognition and signaling

por Zhuang, Youwen, Liu, Heng, Edward Zhou, X., Kumar Verma, Ravi, de Waal, Parker W., Jang, Wonjo, Xu, Ting-Hai, Wang, Lei, Meng, Xing, Zhao, Gongpu, Kang, Yanyong, Melcher, Karsten, Fan, Hao, Lambert, Nevin A., Eric Xu, H., Zhang, Cheng
Publicado 2020

Crystal structure of the human 5-HT(1B) serotonin receptor bound to an inverse agonist

por Yin, Wanchao, Zhou, X. Edward, Yang, Dehua, de Waal, Parker W., Wang, Meitian, Dai, Antao, Cai, Xiaoqing, Huang, Chia-Ying, Liu, Ping, Wang, Xiaoxi, Yin, Yanting, Liu, Bo, Zhou, Yu, Wang, Jiang, Liu, Hong, Caffrey, Martin, Melcher, Karsten, Xu, Yechun, Wang, Ming-Wei, Xu, H. Eric, Jiang, Yi
Publicado 2018

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex

por Zhou, X. Edward, Gao, Xiang, Barty, Anton, Kang, Yanyong, He, Yuanzheng, Liu, Wei, Ishchenko, Andrii, White, Thomas A., Yefanov, Oleksandr, Han, Gye Won, Xu, Qingping, de Waal, Parker W., Suino-Powell, Kelly M., Boutet, Sébastien, Williams, Garth J., Wang, Meitian, Li, Dianfan, Caffrey, Martin, Chapman, Henry N., Spence, John C.H., Fromme, Petra, Weierstall, Uwe, Stevens, Raymond C., Cherezov, Vadim, Melcher, Karsten, Xu, H. Eric
Publicado 2016

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

por Kang, Yanyong, Zhou, X. Edward, Gao, Xiang, He, Yuanzheng, Liu, Wei, Ishchenko, Andrii, Barty, Anton, White, Thomas A., Yefanov, Oleksandr, Han, Gye Won, Xu, Qingping, de Waal, Parker W., Ke, Jiyuan, Eileen Tan, M. H., Zhang, Chenghai, Moeller, Arne, West, Graham M., Pascal, Bruce, Van Eps, Ned, Caro, Lydia N., Vishnivetskiy, Sergey A., Lee, Regina J., Suino-Powell, Kelly M., Gu, Xin, Pal, Kuntal, Ma, Jinming, Zhi, Xiaoyong, Boutet, Sébastien, Williams, Garth J., Messerschmidt, Marc, Gati, Cornelius, Zatsepin, Nadia A., Wang, Dingjie, James, Daniel, Basu, Shibom, Roy-Chowdhury, Shatabdi, Conrad, Chelsie, Coe, Jesse, Liu, Haiguang, Lisova, Stella, Kupitz, Christopher, Grotjohann, Ingo, Fromme, Raimund, Jiang, Yi, Tan, Minjia, Yang, Huaiyu, Li, Jun, Wang, Meitian, Zheng, Zhong, Li, Dianfan, Howe, Nicole, Zhao, Yingming, Standfuss, Jörg, Diederichs, Kay, Dong, Yuhui, Potter, Clinton S, Carragher, Bridget, Caffrey, Martin, Jiang, Hualiang, Chapman, Henry N., Spence, John C. H., Fromme, Petra, Weierstall, Uwe, Ernst, Oliver P., Katritch, Vsevolod, Gurevich, Vsevolod V., Griffin, Patrick R., Hubbell, Wayne L., Stevens, Raymond C., Cherezov, Vadim, Melcher, Karsten, Xu, H. Eric
Publicado 2015