IL-31–IL-31R interactions negatively regulate type 2 inflammation in the lung

por Perrigoue, Jacqueline G., Li, Ji, Zaph, Colby, Goldschmidt, Michael, Scott, Phillip, de Sauvage, Frederic J., Pearce, Edward J., Ghilardi, Nico, Artis, David
Publicado 2007

Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging

por Ritsma, Laila, Ellenbroek, Saskia I.J., Zomer, Anoek, Snippert, Hugo J., de Sauvage, Frederic J., Simons, Benjamin D., Clevers, Hans, van Rheenen, Jacco
Publicado 2014

Parasitic helminthes induce fetal-like reversion in the intestinal stem cell niche

por Nusse, Ysbrand M., Savage, Adam K., Marangoni, Pauline, Rosendahl-Huber, Axel K.M., Landman, Tyler A., de Sauvage, Frederic J., Locksley, Richard M., Klein, Ophir D.
Publicado 2018

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

por Lin, Kui, Taylor, James R., Wu, Thomas D., Gutierrez, Johnny, Elliott, J. Michael, Vernes, Jean-Michel, Koeppen, Hartmut, Phillips, Heidi S., de Sauvage, Frederic J., Meng, Y. Gloria
Publicado 2011

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

por Khader, Shabaana A., Partida-Sanchez, Santiago, Bell, Guy, Jelley-Gibbs, Dawn M., Swain, Susan, Pearl, John E., Ghilardi, Nico, deSauvage, Frederic J., Lund, Frances E., Cooper, Andrea M.
Publicado 2006

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway.

por Leow, Ching Ching, Wang, Bu-er, Ross, Jed, Chan, Sara M., Zha, Jiping, Carano, Richard A. D., Frantz, Gretchen, Shen, Michael M., de Sauvage, Frederic J., Gao, Wei-Qiang
Publicado 2011

Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

por Hansen, Simon, Zhang, Yingnan, Hwang, Sunhee, Nabhan, Ahmad, Li, Wanqing, Fuhrmann, Jakob, Kschonsak, Yvonne, Zhou, Lijuan, Nile, Aaron H., Gao, Xinxin, Piskol, Robert, de Sousa e Melo, Felipe, de Sauvage, Frederic J., Hannoush, Rami N.
Publicado 2022

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

por Hegde, Ganapati V, de la Cruz, Cecile, Giltnane, Jennifer M, Crocker, Lisa, Venkatanarayan, Avinashnarayan, Schaefer, Gabriele, Dunlap, Debra, Hoeck, Joerg D, Piskol, Robert, Gnad, Florian, Modrusan, Zora, de Sauvage, Frederic J, Siebel, Christian W, Jackson, Erica L
Publicado 2019

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

por Batten, Marcel, Ramamoorthi, Nandhini, Kljavin, Noelyn M., Ma, Cindy S., Cox, Jennifer H., Dengler, Hart S., Danilenko, Dimitry M., Caplazi, Patrick, Wong, Melanie, Fulcher, David A., Cook, Matthew C., King, Cecile, Tangye, Stuart G., de Sauvage, Frederic J., Ghilardi, Nico
Publicado 2010

Lgr5+ telocytes are a signaling source at the intestinal villus tip

por Bahar Halpern, Keren, Massalha, Hassan, Zwick, Rachel K., Moor, Andreas E., Castillo-Azofeifa, David, Rozenberg, Milena, Farack, Lydia, Egozi, Adi, Miller, Dan R., Averbukh, Inna, Harnik, Yotam, Weinberg-Corem, Noa, de Sauvage, Frederic J., Amit, Ido, Klein, Ophir D., Shoshkes-Carmel, Michal, Itzkovitz, Shalev
Publicado 2020

Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

por Kurtova, Antonina V., Heinlein, Melanie, Haas, Simon, Velten, Lars, Dijkgraaf, Gerrit J. P., Storm, Elaine E., Kljavin, Noelyn M., Boumahdi, Soufiane, Himmels, Patricia, Herault, Aurelie, Mancini, Andrew, Koeppen, Hartmut, Dail, Monique, Yan, Qingxiang, Zhang, Jianhuan, Koch, Ute, Radtke, Freddy, Modrusan, Zora, Metcalfe, Ciara, Piskol, Robert, de Sauvage, Frederic J.
Publicado 2022

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

por Catenacci, Daniel V.T., Junttila, Melissa R., Karrison, Theodore, Bahary, Nathan, Horiba, Margit N., Nattam, Sreenivasa R., Marsh, Robert, Wallace, James, Kozloff, Mark, Rajdev, Lakshmi, Cohen, Deirdre, Wade, James, Sleckman, Bethany, Lenz, Heinz-Josef, Stiff, Patrick, Kumar, Pankaj, Xu, Peng, Henderson, Les, Takebe, Naoko, Salgia, Ravi, Wang, Xi, Stadler, Walter M., de Sauvage, Frederic J., Kindler, Hedy L.
Publicado 2015

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

por Taraborrelli, Lucia, Şenbabaoğlu, Yasin, Wang, Lifen, Lim, Junghyun, Blake, Kerrigan, Kljavin, Noelyn, Gierke, Sarah, Scherl, Alexis, Ziai, James, McNamara, Erin, Owyong, Mark, Rao, Shilpa, Calviello, Aslihan Karabacak, Oreper, Daniel, Jhunjhunwala, Suchit, Argiles, Guillem, Bendell, Johanna, Kim, Tae Won, Ciardiello, Fortunato, Wongchenko, Matthew J., de Sauvage, Frederic J., de Sousa e Melo, Felipe, Yan, Yibing, West, Nathaniel R., Murthy, Aditya
Publicado 2023

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

por Liu, Jinfeng, McCleland, Mark, Stawiski, Eric W., Gnad, Florian, Mayba, Oleg, Haverty, Peter M., Durinck, Steffen, Chen, Ying-Jiun, Klijn, Christiaan, Jhunjhunwala, Suchit, Lawrence, Michael, Liu, Hanbin, Wan, Yinan, Chopra, Vivek, Yaylaoglu, Murat B., Yuan, Wenlin, Ha, Connie, Gilbert, Houston N., Reeder, Jens, Pau, Gregoire, Stinson, Jeremy, Stern, Howard M., Manning, Gerard, Wu, Thomas D., Neve, Richard M., de Sauvage, Frederic J., Modrusan, Zora, Seshagiri, Somasekar, Firestein, Ron, Zhang, Zemin
Publicado 2014

Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma

por Yurchenko, Andrey A., Pop, Oltin T., Ighilahriz, Meriem, Padioleau, Ismael, Rajabi, Fatemeh, Sharpe, Hayley J., Poulalhon, Nicolas, Dreno, Brigitte, Khammari, Amir, Delord, Marc, Alberti, Antonio, Soufir, Nadem, Battistella, Maxime, Mourah, Samia, Bouquet, Fanny, Savina, Ariel, Besse, Andrej, Mendez-Lopez, Max, Grange, Florent, Monestier, Sandrine, Mortier, Laurent, Meyer, Nicolas, Dutriaux, Caroline, Robert, Caroline, Saiag, Philippe, Herms, Florian, Lambert, Jerome, de Sauvage, Frederic J., Dumaz, Nicolas, Flatz, Lukas, Basset-Seguin, Nicole, Nikolaev, Sergey I.
Publicado 2022

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

por Liu, Jinfeng, Lee, William, Jiang, Zhaoshi, Chen, Zhongqiang, Jhunjhunwala, Suchit, Haverty, Peter M., Gnad, Florian, Guan, Yinghui, Gilbert, Houston N., Stinson, Jeremy, Klijn, Christiaan, Guillory, Joseph, Bhatt, Deepali, Vartanian, Steffan, Walter, Kimberly, Chan, Jocelyn, Holcomb, Thomas, Dijkgraaf, Peter, Johnson, Stephanie, Koeman, Julie, Minna, John D., Gazdar, Adi F., Stern, Howard M., Hoeflich, Klaus P., Wu, Thomas D., Settleman, Jeff, de Sauvage, Frederic J., Gentleman, Robert C., Neve, Richard M., Stokoe, David, Modrusan, Zora, Seshagiri, Somasekar, Shames, David S., Zhang, Zemin
Publicado 2012

Antibody targeting of E3 ubiquitin ligases for receptor degradation

por Marei, Hadir, Tsai, Wen-Ting K., Kee, Yee-Seir, Ruiz, Karen, He, Jieyan, Cox, Chris, Sun, Tao, Penikalapati, Sai, Dwivedi, Pankaj, Choi, Meena, Kan, David, Saenz-Lopez, Pablo, Dorighi, Kristel, Zhang, Pamela, Kschonsak, Yvonne T., Kljavin, Noelyn, Amin, Dhara, Kim, Ingrid, Mancini, Andrew G., Nguyen, Thao, Wang, Chunling, Janezic, Eric, Doan, Alexander, Mai, Elaine, Xi, Hongkang, Gu, Chen, Heinlein, Melanie, Biehs, Brian, Wu, Jia, Lehoux, Isabelle, Harris, Seth, Comps-Agrar, Laetitia, Seshasayee, Dhaya, de Sauvage, Frederic J., Grimmer, Matthew, Li, Jing, Agard, Nicholas J., de Sousa e Melo, Felipe
Publicado 2022