Xenograft and organoid model systems in cancer research

por Bleijs, Margit, van de Wetering, Marc, Clevers, Hans, Drost, Jarno
Publicado 2019

Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

por Visser, Lindy L., Bleijs, Margit, Margaritis, Thanasis, van de Wetering, Marc, Holstege, Frank C. P., Clevers, Hans
Publicado 2023

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model

por Bleijs, Margit, Pleijte, Corine, Engels, Sem, Ringnalda, Femke, Meyer-Wentrup, Friederike, van de Wetering, Marc, Clevers, Hans
Publicado 2021

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

por Blache, Philippe, van de Wetering, Marc, Duluc, Isabelle, Domon, Claire, Berta, Philippe, Freund, Jean-Noël, Clevers, Hans, Jay, Philippe
Publicado 2004

Canine Pituitary Organoids as 3D In Vitro Model for Cushing Disease

por Sanders, Karin, Ringnalda, Femke C A, van de Wetering, Marc L, Kooistra, Hans S, Meij, Björn P, Clevers, Hans, Galac, Sara
Publicado 2021

Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

por Mokry, Michal, Hatzis, Pantelis, de Bruijn, Ewart, Koster, Jan, Versteeg, Rogier, Schuijers, Jurian, van de Wetering, Marc, Guryev, Victor, Clevers, Hans, Cuppen, Edwin
Publicado 2010

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

por Simmini, Salvatore, Bialecka, Monika, Huch, Meritxell, Kester, Lennart, van de Wetering, Marc, Sato, Toshiro, Beck, Felix, van Oudenaarden, Alexander, Clevers, Hans, Deschamps, Jacqueline
Publicado 2014

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

por Hanemaaijer, Evelyn S., Margaritis, Thanasis, Sanders, Karin, Bos, Frank L., Candelli, Tito, Al-Saati, Hanin, van Noesel, Max M., Meyer-Wentrup, Friederike A. G., van de Wetering, Marc, Holstege, Frank C. P., Clevers, Hans
Publicado 2021

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

por Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, van Gerwen, Bastiaan, van der Ven, Marieke, van de Wetering, Marc, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Publicado 2016

Lrig1 controls intestinal stem cell homeostasis by negative regulation of ErbB signalling

por Wong, Vivian W.Y., Stange, Daniel E., Page, Mahalia E., Buczacki, Simon, Wabik, Agnieszka, Itami, Satoshi, van de Wetering, Marc, Poulsom, Richard, Wright, Nicholas A., Trotter, Matthew W.B., Watt, Fiona M., Winton, Doug J., Clevers, Hans, Jensen, Kim B.
Publicado 2012

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

por Kaaij, Lucas TJ, van de Wetering, Marc, Fang, Fang, Decato, Benjamin, Molaro, Antoine, van de Werken, Harmen JG, van Es, Johan H, Schuijers, Jurian, de Wit, Elzo, de Laat, Wouter, Hannon, Gregory J, Clevers, Hans C, Smith, Andrew D, Ketting, René F
Publicado 2013

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

por Paassen, Irene, Williams, Justin, Ríos Arceo, Carla, Ringnalda, Femke, Mercer, Kimberly Shea, Buhl, Juliane L., Moreno, Natalia, Federico, Aniello, Franke, Niels E., Kranendonk, Mariette, Upadhyaya, Santhosh A., Kerl, Kornelius, van de Wetering, Marc, Clevers, Hans, Kool, Marcel, Hoving, Eelco W., Roussel, Martine F., Drost, Jarno
Publicado 2023

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

por Huch, Meritxell, Bonfanti, Paola, Boj, Sylvia F, Sato, Toshiro, Loomans, Cindy J M, van de Wetering, Marc, Sojoodi, Mozhdeh, Li, Vivian S W, Schuijers, Jurian, Gracanin, Ana, Ringnalda, Femke, Begthel, Harry, Hamer, Karien, Mulder, Joyce, van Es, Johan H, de Koning, Eelco, Vries, Robert G J, Heimberg, Harry, Clevers, Hans
Publicado 2013

Single-cell dissection of transcriptional heterogeneity in human colon tumors

por Dalerba, Piero, Kalisky, Tomer, Sahoo, Debashis, Rajendran, Pradeep S., Rothenberg, Michael E., Leyrat, Anne A., Sim, Sopheak, Okamoto, Jennifer, Johnston, Darius M., Qian, Dalong, Zabala, Maider, Bueno, Janet, Neff, Norma F., Wang, Jianbin, Shelton, Andrew A., Visser, Brendan, Hisamori, Shigeo, Shimono, Yohei, van de Wetering, Marc, Clevers, Hans, Clarke, Michael F., Quake, Stephen R.
Publicado 2011

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

por Huch, Meritxell, Gehart, Helmuth, van Boxtel, Ruben, Hamer, Karien, Blokzijl, Francis, Verstegen, Monique M.A., Ellis, Ewa, van Wenum, Martien, Fuchs, Sabine A., de Ligt, Joep, van de Wetering, Marc, Sasaki, Nobuo, Boers, Susanne J., Kemperman, Hans, de Jonge, Jeroen, Ijzermans, Jan N.M., Nieuwenhuis, Edward E.S., Hoekstra, Ruurdtje, Strom, Stephen, Vries, Robert R.G., van der Laan, Luc J.W., Cuppen, Edwin, Clevers, Hans
Publicado 2015

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development

por Weren, Robbert DA, Venkatachalam, Ramprasath, Cazier, Jean‐Baptiste, Farin, Henner F, Kets, C Marleen, de Voer, Richarda M, Vreede, Lilian, Verwiel, Eugène TP, van Asseldonk, Monique, Kamping, Eveline J, Kiemeney, Lambertus A, Neveling, Kornelia, Aben, Katja KH, Carvajal‐Carmona, Luis, Nagtegaal, Iris D, Schackert, Hans K, Clevers, Hans, van de Wetering, Marc, Tomlinson, Ian P, Ligtenberg, Marjolijn JL, Hoogerbrugge, Nicoline, Geurts van Kessel, Ad, Kuiper, Roland P
Publicado 2015

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

por Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C P
Publicado 2022

FANTOM5 CAGE profiles of human and mouse samples

por Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter, Axton, Richard A., Babina, Magda, Baillie, J. Kenneth, Barnett, Timothy C., Beckhouse, Anthony G., Blumenthal, Antje, Bodega, Beatrice, Bonetti, Alessandro, Briggs, James, Brombacher, Frank, Carlisle, Ailsa J., Clevers, Hans C., Davis, Carrie A., Detmar, Michael, Dohi, Taeko, Edge, Albert S.B., Edinger, Matthias, Ehrlund, Anna, Ekwall, Karl, Endoh, Mitsuhiro, Enomoto, Hideki, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Farach-Carson, Mary C., Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E., Forrester, Lesley M., Fujita, Rie, Furusawa, Jun-ichi, Geijtenbeek, Teunis B., Gingeras, Thomas, Goldowitz, Daniel, Guhl, Sven, Guler, Reto, Gustincich, Stefano, Ha, Thomas J., Hamaguchi, Masahide, Hara, Mitsuko, Hasegawa, Yuki, Herlyn, Meenhard, Heutink, Peter, Hitchens, Kelly J., Hume, David A., Ikawa, Tomokatsu, Ishizu, Yuri, Kai, Chieko, Kawamoto, Hiroshi, Kawamura, Yuki I., Kempfle, Judith S., Kenna, Tony J., Kere, Juha, Khachigian, Levon M., Kitamura, Toshio, Klein, Sarah, Klinken, S. Peter, Knox, Alan J., Kojima, Soichi, Koseki, Haruhiko, Koyasu, Shigeo, Lee, Weonju, Lennartsson, Andreas, Mackay-sim, Alan, Mejhert, Niklas, Mizuno, Yosuke, Morikawa, Hiromasa, Morimoto, Mitsuru, Moro, Kazuyo, Morris, Kelly J., Motohashi, Hozumi, Mummery, Christine L., Nakachi, Yutaka, Nakahara, Fumio, Nakamura, Toshiyuki, Nakamura, Yukio, Nozaki, Tadasuke, Ogishima, Soichi, Ohkura, Naganari, Ohno, Hiroshi, Ohshima, Mitsuhiro, Okada-Hatakeyama, Mariko, Okazaki, Yasushi, Orlando, Valerio, Ovchinnikov, Dmitry A., Passier, Robert, Patrikakis, Margaret, Pombo, Ana, Pradhan-Bhatt, Swati, Qin, Xian-Yang, Rehli, Michael, Rizzu, Patrizia, Roy, Sugata, Sajantila, Antti, Sakaguchi, Shimon, Sato, Hiroki, Satoh, Hironori, Savvi, Suzana, Saxena, Alka, Schmidl, Christian, Schneider, Claudio, Schulze-Tanzil, Gundula G., Schwegmann, Anita, Sheng, Guojun, Shin, Jay W., Sugiyama, Daisuke, Sugiyama, Takaaki, Summers, Kim M., Takahashi, Naoko, Takai, Jun, Tanaka, Hiroshi, Tatsukawa, Hideki, Tomoiu, Andru, Toyoda, Hiroo, van de Wetering, Marc, van den Berg, Linda M., Verardo, Roberto, Vijayan, Dipti, Wells, Christine A., Winteringham, Louise N., Wolvetang, Ernst, Yamaguchi, Yoko, Yamamoto, Masayuki, Yanagi-Mizuochi, Chiyo, Yoneda, Misako, Yonekura, Yohei, Zhang, Peter G., Zucchelli, Silvia, Abugessaisa, Imad, Arner, Erik, Harshbarger, Jayson, Kondo, Atsushi, Lassmann, Timo, Lizio, Marina, Sahin, Serkan, Sengstag, Thierry, Severin, Jessica, Shimoji, Hisashi, Suzuki, Masanori, Suzuki, Harukazu, Kawai, Jun, Kondo, Naoto, Itoh, Masayoshi, Daub, Carsten O., Kasukawa, Takeya, Kawaji, Hideya, Carninci, Piero, Forrest, Alistair R.R., Hayashizaki, Yoshihide
Publicado 2017