P107: A PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MITAPIVAT IN PATIENTS WITH SICKLE CELL DISEASE

por Howard, J, Kuo, K, Oluyadi, A, Shao, H, Morris, S, Zaidi, A, Van Beers, E, Thein, S
Publicado 2022

A multiplex PCR predictor for aCGH success of FFPE samples

por van Beers, E H, Joosse, S A, Ligtenberg, M J, Fles, R, Hogervorst, F B L, Verhoef, S, Nederlof, P M
Publicado 2006

Discovering genetic profiles by array-CGH in familial breast tumors

por Nederlof, PM, van Beers, E, Joosse, S, Hogervorst, FBL, Wessels, LFA, Devilee, P, Cornelisse, C, Oldenburg, R, Verhoef, S, van 't Veer, LJ
Publicado 2005

P1492: PHARMACODYNAMIC EFFECTS OF AG-946, A HIGHLY POTENT NOVEL ACTIVATOR OF PYRUVATE KINASE, IN EX VIVO TREATMENT OF RED BLOOD CELLS FROM SICKLE CELL DISEASE PATIENTS

por Rab, M., van Dijk, M., Bos, J., van Oirschot, B., Gerrits, J., Kosinski, P., Kung, C., Jans, J., van Beers, E., Dang, L., van Wijk, R.
Publicado 2022

P1735: IMPROVEMENTS IN PATIENT-REPORTED OUTCOMES IN MITAPIVAT-TREATED PATIENTS WITH PYRUVATE KINASE DEFICIENCY: A DESCRIPTIVE ANALYSIS FROM THE PHASE 3 ACTIVATE TRIAL

por Kuo, K. H., Grace, R. F., van Beers, E. J., Barcellini, W., Glenthøj, A., Holzhauer, S., Patel, P., Beynon, V., Li, J., Zagadailov, E., Al-Samkari, H.
Publicado 2022

P1542: COMORBIDITIES AND COMPLICATIONS ACROSS GENOTYPES IN ADULT PATIENTS WITH PYRUVATE KINASE DEFICIENCY: ANALYSIS FROM THE PEAK REGISTRY

por Glenthøj, A., Grace, R. F., van Beers, E. J., Vives Corrons, J.-L., Glader, B., Kuo, K. H. M., Lander, C., Pospíŝilová, D., Williams, J., Yan, Y., McGee, B., Bianchi, P.
Publicado 2022

P1566: PROTON PUMP INHIBITION FOR SECONDARY HEMOCHROMATOSIS IN HEREDITARY ANEMIA, A PHASE III PLACEBO-CONTROLLED RANDOMIZED CROSS-OVER CLINICAL TRIAL

por Van Vuren, A., Kerkhoffs, J., Schols, S., Rijneveld, A., Nur, E., Peereboom, D., Gandon, Y., Welsing, P., van Wijk, R., Schutgens, R., van Solinge, W., Marx, J., Leiner, T., Biemond, B., van Beers, E.
Publicado 2022

P1565: MITAPIVAT IMPROVES INEFFECTIVE ERYTHROPOIESIS AND REDUCES IRON OVERLOAD IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY

por van Beers, E. J., Al-Samkari, H., Grace, R. F., Barcellini, W., Glenthøj, A., Judge, M. P., Kosinski, P. A., Xu, R., Beynon, V., McGee, B., Porter, J. B., Kuo, K. H. M.
Publicado 2022

P1500: 2,3-DIPHOSPHOGLYCERATE DETECTION VIA DIRECT INFUSION HIGH RESOLUTION MASS SPECTROMETRY CORRELATES WITH QUANTITATIVE DETECTION IN BLOOD OF PATIENTS WITH SICKLE CELL DISEASE

por van der Veen, S., van Dijk, M., Jans, J., Verhoeven-Duif, N., van Wijk, R., Bartels, M., Mañú Pereira, M., Colombatti, R., Martella, M., Munaretto, V., Boaro, M., Bartolucci, P., Cnossen, M., Biemond, B., van Beers, E.
Publicado 2022

Ektacytometry Analysis of Post-splenectomy Red Blood Cell Properties Identifies Cell Membrane Stability Test as a Novel Biomarker of Membrane Health in Hereditary Spherocytosis

por Berrevoets, M. C., Bos, J., Huisjes, R., Merkx, T. H., van Oirschot, B. A., van Solinge, W. W., Verweij, J. W., Lindeboom, M. Y. A., van Beers, E. J., Bartels, M., van Wijk, R., Rab, M. A. E.
Publicado 2021

P1562: CHARACTERIZING IRON OVERLOAD BY AGE IN PATIENTS DIAGNOSED WITH PYRUVATE KINASE DEFICIENCY – A DESCRIPTIVE ANALYSIS FROM THE PEAK REGISTRY

por Bianchi, P., Grace, R. F., Vives Corrons, J.-L., Glader, B., Glenthøj, A., Kanno, H., Kuo, K. H., Lander, C., Layton, D. M., Pospíŝilová, D., Viprakasit, V., Williams, J., Yan, Y., McGee, B., van Beers, E. J.
Publicado 2022

P1478: INTEGRATIVE DIAGNOSIS OF SICKLE CELL DISEASE PATIENTS FOR PERSONALIZED MEDICINE

por Idrizovic, A., Collado Gimbert, A., van Beers, E., Colombatti, R., Bartolucci, P., de Montalembert, M., Boaro, M. P., Beneitez, D., Ortuño, A., Ruiz, A., Isola, I., Cela, E., Van Wijk, R., Rab, M., Mañú Pereira, M. D. M.
Publicado 2022

P1548: LONG-TERM TREATMENT WITH ORAL MITAPIVAT IS ASSOCIATED WITH NORMALIZATION OF HEMOGLOBIN LEVELS IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY

por Barcellini, W., Grace, R. F., Al-Samkari, H., Glenthøj, A., Rothman, J. A., Morado Arias, M., Layton, D. M., Andres, O., DiBacco, M., Hawkins, P., Judge, M. P., Tai, F., Morales-Arias, J., Beynon, V., van Beers, E. J.
Publicado 2022

P1065: CONGENITAL ERYTHROCYTOSIS DUE TO HETEROZYGOUS VARIANTS IN THE BISPHOSPHOGLYCERATE MUTASE GENE

por van Dijk, M. J., van Oirschot, B. A., Stam-Slob, M. C., van der Zwaag, B., van Beers, E. J., Jans, J. J., van der Linden, P., Torregrosa Diaz, J. M., Gardie, B., Girodon, F., Schots, R., Thielen, N., van Wijk, R.
Publicado 2022

P1544: BONE MINERAL DENSITY REMAINS STABLE IN PYRUVATE KINASE DEFICIENCY PATIENTS RECEIVING LONG-TERM TREATMENT WITH MITAPIVAT

por Al-Samkari, H., Grace, R. F., Glenthøj, A., Andres, O., Barcellini, W., Galactéros, F., Kuo, K. H. M., Layton, D. M., Morado Arias, M., Viprakasit, V., Dong, Y., Tai, F., Grekas, L., Khoja, K., Gheuens, S., McGee, B., Porter, J. B., van Beers, E. J.
Publicado 2022

P1501: FOLLOW-UP RESULTS OF A PHASE 2 STUDY ASSESSING THE SAFETY AND EFFICACY OF MITAPIVAT TREATMENT, AN ORAL PYRUVATE KINASE ACTIVATOR, FOR UP TO 60 WEEKS IN SUBJECTS WITH SICKLE...

por van Dijk, M. J., Rab, M. A., van Oirschot, B. A., Bos, J., Derichs, C., Rijneveld, A. W., Cnossen, M. H., Nur, E., Biemond, B. J., Bartels, M., Jans, J. J., van Solinge, W. W., Schutgens, R. E., van Wijk, R., van Beers, E. J.
Publicado 2022

5589320 FOLLOW-UP RESULTS OF A PHASE 2 STUDY ASSESSING THE SAFETY AND EFFICACY OF MITAPIVAT TREATMENT, AN ORAL PYRUVATE KINASE ACTIVATOR, FOR UP TO 60 WEEKS IN SUBJECTS WITH SICKLE...

por van Dijk, M.J., Rab, M.A.E., van Oirschot, B.A., Bos, J.F., Derichs, C., Rijneveld, A.W., Cnossen, M.H., Nur, E., Biemond, B.J., Bartels, M., Jans, J.J.M., van Solinge, W.W., Schutgens, R.E.G., van Wijk, R., van Beers, E.J.
Publicado 2023

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients

por Vollebergh, M. A., Lips, E. H., Nederlof, P. M., Wessels, L. F. A., Schmidt, M. K., van Beers, E. H., Cornelissen, S., Holtkamp, M., Froklage, F. E., de Vries, E. G. E., Schrama, J. G., Wesseling, J., van de Vijver, M. J., van Tinteren, H., de Bruin, M., Hauptmann, M., Rodenhuis, S., Linn, S. C.
Publicado 2011

P1545: DURABILITY OF HEMOGLOBIN RESPONSE AND REDUCTION IN TRANSFUSION BURDEN IS MAINTAINED OVER TIME IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY TREATED WITH MITAPIVAT IN A LONG-TE...

por Grace, R. F., Glenthøj, A., Barcellini, W., Verhovsek, M., Rothman, J. A., Morado Arias, M., Layton, D. M., Andres, O., Galactéros, F., van Beers, E. J., Onodera, K., Viprakasit, V., Chonat, S., Porter, J. B., Judge, M. P., Kosinski, P. A., Hawkins, P., Gheuens, S., Xu, R., McGee, B., Beynon, V., Al-Samkari, H.
Publicado 2022