CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity

por Zammarchi, Francesca, Havenith, Karin, Bertelli, Francois, Vijayakrishnan, Balakumar, Chivers, Simon, van Berkel, Patrick H
Publicado 2020

Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers

por Zammarchi, Francesca, Havenith, Karin EG., Chivers, Simon, Hogg, Paul, Bertelli, Francois, Tyrer, Peter, Janghra, Narinder, Reinert, Halla W., Hartley, John A., van Berkel, Patrick H.
Publicado 2022

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

por Rose, Rebecca J., van Berkel, Patrick H.C., van den Bremer, Ewald T.J., Labrijn, Aran F., Vink, Tom, Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.
Publicado 2013

Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus

por Moore, Kate M., Desai, Ami, Delgado, Bea de Luxán, Trabulo, Sara Maria David, Reader, Claire, Brown, Nicholas F., Murray, Elizabeth R., Brentnall, Adam, Howard, Philip, Masterson, Luke, Zammarchi, Francesca, Hartley, John A., van Berkel, Patrick H., Marshall, John F.
Publicado 2020

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

por Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.
Publicado 2018