A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly...

por Hijma, Hemme J., van Brummelen, Emilie M. J., Siebenga, Pieter S., Groeneveld, Geert Jan
Publicado 2021

Touchscreen-based finger tapping: Repeatability and configuration effects on tapping performance

por Makai-Bölöni, Soma, Thijssen, Eva, van Brummelen, Emilie M. J., Groeneveld, Geert J., Doll, Robert J.
Publicado 2021

Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds

por Radanovic, Igor, Klarenbeek, Naomi, Rissmann, Robert, Groeneveld, Geert Jan, van Brummelen, Emilie M. J., Moerland, Matthijs, Bosch, Jacobus J.
Publicado 2022

A Placebo‐Controlled Study to Assess the Sensitivity of Finger Tapping to Medication Effects in Parkinson's Disease

por Thijssen, Eva, Makai‐Bölöni, Soma, van Brummelen, Emilie, den Heijer, Jonas, Yavuz, Yalcin, Doll, Robert‐Jan, Groeneveld, Geert Jan
Publicado 2022

Objective Monitoring of Facioscapulohumeral Dystrophy During Clinical Trials Using a Smartphone App and Wearables: Observational Study

por Maleki, Ghobad, Zhuparris, Ahnjili, Koopmans, Ingrid, Doll, Robert J, Voet, Nicoline, Cohen, Adam, van Brummelen, Emilie, Groeneveld, Geert Jan, De Maeyer, Joris
Publicado 2022

Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season

por Van Der Plas, Johan L., Verdijk, Pauline, Van Brummelen, Emilie M. J., Jeeninga, Rienk E., Roestenberg, Meta, Burggraaf, Jacobus, Kamerling, Ingrid M.C.
Publicado 2019

Healthy volunteers in first‐in‐human oncology drug development for small molecules

por de las Heras, Begoña, Bouyoucef‐Cherchalli, Dalila, Reeve, Lesley, Reichl, Andreas, Mandarino, Debra, Flach, Stephen, Vidal, Laura, van Brummelen, Emilie M. J., Steeghs, Neeltje
Publicado 2021

Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional Study

por Zhuparris, Ahnjili, Maleki, Ghobad, Koopmans, Ingrid, Doll, Robert J, Voet, Nicoline, Kraaij, Wessel, Cohen, Adam, van Brummelen, Emilie, De Maeyer, Joris H, Groeneveld, Geert Jan
Publicado 2023

Quantification of tremor using consumer product accelerometry is feasible in patients with essential tremor and Parkinson’s disease: a comparative study

por van Brummelen, Emilie M. J., Ziagkos, Dimitrios, de Boon, Wadim M. I., Hart, Ellen P., Doll, Robert J., Huttunen, Teppo, Kolehmainen, Petteri, Groeneveld, Geert Jan
Publicado 2020

A Randomized First‐in‐Human Study With UB‐312, a UBITh® α‐Synuclein Peptide Vaccine

por Yu, Hui Jing, Thijssen, Eva, van Brummelen, Emilie, van der Plas, Johan L., Radanovic, Igor, Moerland, Matthijs, Hsieh, Eric, Groeneveld, Geert Jan, Dodart, Jean‐Cosme
Publicado 2022

First‐in‐human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR‐324, a dual enkephalinase inhibitor for pain management

por Moss, Laurence M., Berends, Cecile L., van Brummelen, Emilie M. J., Kamerling, Ingrid M. C., Klaassen, Erica S., Bergmann, Kirsten, Ville, Vanessa, Juarez‐Perez, Victor, Benichou, Annie‐Claude, Groeneveld, Geert Jan
Publicado 2021

A Randomized Trial Assessing the Safety, Pharmacokinetics, and Efficacy During Morning Off of AZ‐009

por Thijssen, Eva, den Heijer, Jonas, Puibert, David, Moss, Laurence, Lei, Mingzu, Hasegawa, David, Keum, Kyo, Mochel, Ken, Ezzeldin Sharaf, Mohammed, Alfredson, Tom, Zeng, Wenxiang, van Brummelen, Emilie, Naranda, Tatjana, Groeneveld, Geert Jan
Publicado 2022

A Phase 1, open-label, multicentre study to compare the capsule and tablet formulations of AZD5363 and explore the effect of food on the pharmacokinetic exposure, safety and tolera...

por Dean, Emma, Banerji, Udai, Schellens, Jan H. M., Krebs, Matthew G., Jimenez, Begona, van Brummelen, Emilie, Bailey, Chris, Casson, Ed, Cripps, Diana, Cullberg, Marie, Evans, Stephen, Foxley, Andrew, Lindemann, Justin, Rugman, Paul, Taylor, Nigel, Turner, Guy, Yates, James, Lawrence, Peter
Publicado 2018

(89)Zr-labeled CEA-targeted IL-2 variant immunocytokine in patients with solid tumors: CEA-mediated tumor accumulation and role of IL-2 receptor-binding

por van Brummelen, Emilie M.J., Huisman, Marc C., de Wit-van der Veen, Linda J., Nayak, Tapan K., Stokkel, Marcel P.M., Mulder, Emma R., Hoekstra, Otto S., Vugts, Danielle J., Van Dongen, Guus A.M.S., Verheul, Henk M., Evers, Stefan, Tessier, Jean J. L., Saro, Jose, Schellens, Jan H.M., Menke-van der Houven van Oordt, C. Willemien
Publicado 2018

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cance...

por van Geel, Robin M. J. M., van Brummelen, Emilie M. J., Eskens, Ferry A. L. M., Huijberts, Sanne C. F. A., de Vos, Filip Y. F. L., Lolkema, Martijn P. J. K., Devriese, Lot A., Opdam, Frans L., Marchetti, Serena, Steeghs, Neeltje, Monkhorst, Kim, Thijssen, Bas, Rosing, Hilde, Huitema, Alwin D. R., Beijnen, Jos H., Bernards, René, Schellens, Jan H. M.
Publicado 2020