Aneuploidy in health, disease, and aging

por Ricke, Robin M., van Deursen, Jan M.
Publicado 2013

Sgo1 as a “guardian spirit” for preventing colon tumorigenesis

por Ricke, Robin M., van Deursen, Jan M.
Publicado 2012

Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?

por Sedivy, John M, van Deursen, Jan M
Publicado 2013

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

por Ricke, Robin M., Jeganathan, Karthik B., van Deursen, Jan M.
Publicado 2011

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

por van Ree, Janine H., Jeganathan, Karthik B., Malureanu, Liviu, van Deursen, Jan M.
Publicado 2010

Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability

por Hamada, Masakazu, Malureanu, Liviu A., Wijshake, Tobias, Zhou, Wei, van Deursen, Jan M.
Publicado 2012

Oncogenic senescence: a multi-functional perspective

por Baker, Darren J., Alimirah, Fatouma, van Deursen, Jan M., Campisi, Judith, Hildesheim, Jeffrey
Publicado 2017

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

por Jeganathan, Karthik, Malureanu, Liviu, Baker, Darren J., Abraham, Susan C., van Deursen, Jan M.
Publicado 2007

RAE1 Is a Shuttling mRNA Export Factor That Binds to a GLEBS-like NUP98 Motif at the Nuclear Pore Complex through Multiple Domains

por Pritchard, Colin E.J., Fornerod, Maarten, Kasper, Lawryn H., van Deursen, Jan M.A.
Publicado 1999

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

por Ricke, Robin M., Jeganathan, Karthik B., Malureanu, Liviu, Harrison, Andrew M., van Deursen, Jan M.
Publicado 2012

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

por Baker, Darren J., Jeganathan, Karthik B., Malureanu, Liviu, Perez-Terzic, Carmen, Terzic, Andre, van Deursen, Jan M.A.
Publicado 2006

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

por Babu, J. Ramesh, Jeganathan, Karthik B., Baker, Darren J., Wu, Xiaosheng, Kang-Decker, Ningling, van Deursen, Jan M.
Publicado 2003

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice

por Jin, Fang, Hamada, Masakazu, Malureanu, Liviu, Jeganathan, Karthik B., Zhou, Wei, Morbeck, Dean E., van Deursen, Jan M.
Publicado 2010

Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates

por Moreno, Cesar L., Yang, Linda, Dacks, Penny A., Isoda, Fumiko, van Deursen, Jan M. A., Mobbs, Charles V.
Publicado 2016

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

por Bussian, Tyler J., Aziz, Asef, Meyer, Charlton F., Swenson, Barbara L., van Deursen, Jan M., Baker, Darren J.
Publicado 2018

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

por Wijshake, Tobias, Malureanu, Liviu A., Baker, Darren J., Jeganathan, Karthik B., van de Sluis, Bart, van Deursen, Jan M.
Publicado 2012

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

por Weaver, Robbyn L, Limzerwala, Jazeel F, Naylor, Ryan M, Jeganathan, Karthik B, Baker, Darren J, van Deursen, Jan M
Publicado 2016

Senescent cells in the development of cardiometabolic disease

por Postmus, Andrea C., Sturmlechner, Ines, Jonker, Johan W., van Deursen, Jan M., van de Sluis, Bart, Kruit, Janine K.
Publicado 2019

sFRP3 inhibition improves age‐related cellular changes in BubR1 progeroid mice

por Cho, Chang Hoon, Yoo, Ki Hyun, Oliveros, Alfredo, Paulson, Summer, Hussaini, Syed Mohammed Qasim, van Deursen, Jan M., Jang, Mi‐Hyeon
Publicado 2019

Senescent cells limit p53 activity via multiple mechanisms to remain viable

por Sturmlechner, Ines, Sine, Chance C., Jeganathan, Karthik B., Zhang, Cheng, Fierro Velasco, Raul O., Baker, Darren J., Li, Hu, van Deursen, Jan M.
Publicado 2022