Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study

por Brouns, Sanne L.N., Provenzale, Isabella, van Geffen, Johanna P., van der Meijden, Paola E.J., Heemskerk, Johan W.M.
Publicado 2020

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

por Govers-Riemslag, José W. P., Konings, Joke, Cosemans, Judith M. E. M., van Geffen, Johanna P., de Laat, Bas, Heemskerk, Johan W. M., Dargaud, Yesim, ten Cate, Hugo
Publicado 2019

Protein C or Protein S deficiency associates with paradoxically impaired platelet‐dependent thrombus and fibrin formation under flow

por Brouns, Sanne L. N., Tullemans, Bibian M. E., Bulato, Cristiana, Perrella, Gina, Campello, Elena, Spiezia, Luca, van Geffen, Johanna P., Kuijpers, Marijke J. E., van Oerle, René, Spronk, Henri M. H., van der Meijden, Paola E. J., Simioni, Paolo, Heemskerk, Johan W. M.
Publicado 2022

Defective Zn(2+) homeostasis in mouse and human platelets with α- and δ-storage pool diseases

por Kiran Gotru, Sanjeev, van Geffen, Johanna P., Nagy, Magdolna, Mammadova-Bach, Elmina, Eilenberger, Julia, Volz, Julia, Manukjan, Georgi, Schulze, Harald, Wagner, Leonard, Eber, Stefan, Schambeck, Christian, Deppermann, Carsten, Brouns, Sanne, Nurden, Paquita, Greinacher, Andreas, Sachs, Ulrich, Nieswandt, Bernhard, Hermanns, Heike M., Heemskerk, Johan W. M., Braun, Attila
Publicado 2019

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

por van Geffen, Johanna P., Swieringa, Frauke, van Kuijk, Kim, Tullemans, Bibian M. E., Solari, Fiorella A., Peng, Bing, Clemetson, Kenneth J., Farndale, Richard W., Dubois, Ludwig J., Sickmann, Albert, Zahedi, René P., Ahrends, Robert, Biessen, Erik A. L., Sluimer, Judith C., Heemskerk, Johan W. M., Kuijpers, Marijke J. E.
Publicado 2020

Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation

por Brouns, Sanne L. N., van Geffen, Johanna P., Campello, Elena, Swieringa, Frauke, Spiezia, Luca, van Oerle, René, Provenzale, Isabella, Verdoold, Remco, Farndale, Richard W., Clemetson, Kenneth J., Spronk, Henri M. H., van der Meijden, Paola E. J., Cavill, Rachel, Kuijpers, Marijke J. E., Castoldi, Elisabetta, Simioni, Paolo, Heemskerk, Johan W. M.
Publicado 2020

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

por van Geffen, Johanna P., Brouns, Sanne L.N., Batista, Joana, McKinney, Harriet, Kempster, Carly, Nagy, Magdolna, Sivapalaratnam, Suthesh, Baaten, Constance C.F.M.J., Bourry, Nikki, Frontini, Mattia, Jurk, Kerstin, Krause, Manuela, Pillitteri, Daniele, Swieringa, Frauke, Verdoold, Remco, Cavill, Rachel, Kuijpers, Marijke J. E., Ouwehand, Willem H., Downes, Kate, Heemskerk, Johan W.M.
Publicado 2019

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

por Nagy, Magdolna, van Geffen, Johanna P., Stegner, David, Adams, David J., Braun, Attila, de Witt, Susanne M., Elvers, Margitta, Geer, Mitchell J., Kuijpers, Marijke J. E., Kunzelmann, Karl, Mori, Jun, Oury, Cécile, Pircher, Joachim, Pleines, Irina, Poole, Alastair W., Senis, Yotis A., Verdoold, Remco, Weber, Christian, Nieswandt, Bernhard, Heemskerk, Johan W. M., Baaten, Constance C. F. M. J.
Publicado 2019

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

por Petersen, Romina, Lambourne, John J., Javierre, Biola M., Grassi, Luigi, Kreuzhuber, Roman, Ruklisa, Dace, Rosa, Isabel M., Tomé, Ana R., Elding, Heather, van Geffen, Johanna P., Jiang, Tao, Farrow, Samantha, Cairns, Jonathan, Al-Subaie, Abeer M., Ashford, Sofie, Attwood, Antony, Batista, Joana, Bouman, Heleen, Burden, Frances, Choudry, Fizzah A., Clarke, Laura, Flicek, Paul, Garner, Stephen F., Haimel, Matthias, Kempster, Carly, Ladopoulos, Vasileios, Lenaerts, An-Sofie, Materek, Paulina M., McKinney, Harriet, Meacham, Stuart, Mead, Daniel, Nagy, Magdolna, Penkett, Christopher J., Rendon, Augusto, Seyres, Denis, Sun, Benjamin, Tuna, Salih, van der Weide, Marie-Elise, Wingett, Steven W., Martens, Joost H., Stegle, Oliver, Richardson, Sylvia, Vallier, Ludovic, Roberts, David J., Freson, Kathleen, Wernisch, Lorenz, Stunnenberg, Hendrik G., Danesh, John, Fraser, Peter, Soranzo, Nicole, Butterworth, Adam S., Heemskerk, Johan W., Turro, Ernest, Spivakov, Mikhail, Ouwehand, Willem H., Astle, William J., Downes, Kate, Kostadima, Myrto, Frontini, Mattia
Publicado 2017