Exploiting DNA repair defects for novel cancer therapies

por van Gent, Dik C., Kanaar, Roland
Publicado 2016

Homologous Recombination Deficiency Testing for BRCA-Like Tumors: The Road to Clinical Validation

por Ladan, Marjolijn M., van Gent, Dik C., Jager, Agnes
Publicado 2021

Ex vivo tumor culture systems for functional drug testing and therapy response prediction

por Meijer, Titia G, Naipal, Kishan AT, Jager, Agnes, van Gent, Dik C
Publicado 2017

The role of DNA dependent protein kinase in synapsis of DNA ends

por Weterings, Eric, Verkaik, Nicole S., Brüggenwirth, Hennie T., Hoeijmakers, Jan H. J., van Gent, Dik C.
Publicado 2010

Correction to: Role of the DNA damage response in prostate cancer formation, progression and treatment

por Zhang, Wenhao, van Gent, Dik C., Incrocci, Luca, van Weerden, Wytske M., Nonnekens, Julie
Publicado 2019

Role of the DNA damage response in prostate cancer formation, progression and treatment

por Zhang, Wenhao, van Gent, Dik C., Incrocci, Luca, van Weerden, Wytske M., Nonnekens, Julie
Publicado 2019

Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner

por Zelensky, Alex N., Schoonakker, Mascha, Brandsma, Inger, Tijsterman, Marcel, van Gent, Dik C., Essers, Jeroen, Kanaar, Roland
Publicado 2020

Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair

por Zhang, Wenhao, Liao, Chen-Yi, Chtatou, Hajar, Incrocci, Luca, van Gent, Dik C., van Weerden, Wytske M., Nonnekens, Julie
Publicado 2019

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

por Inagawa, Takabumi, Wennink, Thomas, Lebbink, Joyce H. G., Keijzers, Guido, Florea, Bogdan I., Verkaik, Nicole S., van Gent, Dik C.
Publicado 2020

Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder

por van den Tempel, Nathalie, Naipal, Kishan A. T., Raams, Anja, van Gent, Dik C., Franckena, Martine, Boormans, Joost L., Kanaar, Roland
Publicado 2018

Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib

por Nonnekens, Julie, van Kranenburg, Melissa, Beerens, Cecile E.M.T., Suker, Mustafa, Doukas, Michael, van Eijck, Casper H.J., de Jong, Marion, van Gent, Dik C.
Publicado 2016

Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response

por Zhang, Wenhao, van Weerden, Wytske M., de Ridder, Corrina M. A., Erkens‐Schulze, Sigrun, Schönfeld, Edgar, Meijer, Titia G., Kanaar, Roland, van Gent, Dik C., Nonnekens, Julie
Publicado 2018

HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair

por Sato, Koichi, Brandsma, Inger, van Rossum-Fikkert, Sari E, Verkaik, Nicole, Oostra, Anneke B, Dorsman, Josephine C, van Gent, Dik C, Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N
Publicado 2020

Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

por Roobol, Stefan J., van den Bent, Irene, van Cappellen, Wiggert A., Abraham, Tsion E., Paul, Maarten W., Kanaar, Roland, Houtsmuller, Adriaan B., van Gent, Dik C., Essers, Jeroen
Publicado 2020

Functional Ex Vivo Tissue-Based Chemotherapy Sensitivity Testing for Breast Cancer

por Ladan, Marjolijn M., Meijer, Titia G., Verkaik, Nicole S., Komar, Zofia M., van Deurzen, Carolien H. M., den Bakker, Michael A., Kanaar, Roland, van Gent, Dik C., Jager, Agnes
Publicado 2022

Autophosphorylation of DNA-PK(CS) regulates its dynamics at DNA double-strand breaks

por Uematsu, Naoya, Weterings, Eric, Yano, Ken-ichi, Morotomi-Yano, Keiko, Jakob, Burkhard, Taucher-Scholz, Gisela, Mari, Pierre-Olivier, van Gent, Dik C., Chen, Benjamin P.C., Chen, David J.
Publicado 2007

Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

por Ruigrok, Eline A. M., Verkaik, Nicole S., de Blois, Erik, de Ridder, Corrina, Stuurman, Debra, Roobol, Stefan J., Van Gent, Dik C., de Jong, Marion, Van Weerden, Wytske M., Nonnekens, Julie
Publicado 2022

Tumor slice culture system to assess drug response of primary breast cancer

por Naipal, Kishan A. T., Verkaik, Nicole S., Sánchez, Humberto, van Deurzen, Carolien H. M., den Bakker, Michael A., Hoeijmakers, Jan H.J., Kanaar, Roland, Vreeswijk, Maaike P.G., Jager, Agnes, van Gent, Dik C.
Publicado 2016

Proof-of-concept study linking ex vivo sensitivity testing to neoadjuvant anthracycline-based chemotherapy response in breast cancer patients

por Ladan, Marjolijn M., Meijer, Titia G., Verkaik, Nicole S., de Monye, Cecile, Koppert, Linetta B., Oomen-de Hoop, Esther, van Deurzen, Carolien H. M., Kanaar, Roland, Nonnekens, Julie, van Gent, Dik C., Jager, Agnes
Publicado 2023

Attenuated XPC Expression Is Not Associated with Impaired DNA Repair in Bladder Cancer

por Naipal, Kishan A. T., Raams, Anja, Bruens, Serena T., Brandsma, Inger, Verkaik, Nicole S., Jaspers, Nicolaas G. J., Hoeijmakers, Jan H. J., van Leenders, Geert J. L. H., Pothof, Joris, Kanaar, Roland, Boormans, Joost, van Gent, Dik C.
Publicado 2015