Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics

por Wolfs, M.G.M, Hofker, M.H, Wijmenga, C, van Haeften, T.W.
Publicado 2009

Platelet Tissue Factor Synthesis in Type 2 Diabetic Patients Is Resistant to Inhibition by Insulin

por Gerrits, Anja J., Koekman, Cornelis A., van Haeften, Timon W., Akkerman, Jan Willem N.
Publicado 2010

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

por Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, J. J., Dekker, J. M., ’t Hart, L. M., Nijpels, G., van Haeften, T. W., Häring, H. U., Fritsche, A.
Publicado 2007

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

por Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, J. J., Dekker, J. M., t’Hart, L. M., Nijpels, G., van Haeften, T. W., Häring, H. U., Fritsche, A.
Publicado 2007

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

por Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, J. J., Dekker, J. M., t’Hart, L. M., Nijpels, G., van Haeften, T. W., Häring, H. U., Fritsche, A.
Publicado 2009

Co-expressed immune and metabolic genes in visceral and subcutaneous adipose tissue from severely obese individuals are associated with plasma HDL and glucose levels: a microarray...

por Wolfs, Marcel GM, Rensen, Sander S, Bruin-Van Dijk, Elinda J, Verdam, Froukje J, Greve, Jan-Willem, Sanjabi, Bahram, Bruinenberg, Marcel, Wijmenga, Cisca, van Haeften, Timon W, Buurman, Wim A, Franke, Lude, Hofker, Marten H
Publicado 2010

Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity

por Wolfs, M G M, Gruben, N, Rensen, S S, Verdam, F J, Greve, J W, Driessen, A, Wijmenga, C, Buurman, W A, Franke, L, Scheja, L, Koonen, D P Y, Shiri-Sverdlov, R, van Haeften, T W, Hofker, M H, Fu, J
Publicado 2015

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function

por Simonis-Bik, Annemarie M., Nijpels, Giel, van Haeften, Timon W., Houwing-Duistermaat, Jeanine J., Boomsma, Dorret I., Reiling, Erwin, van Hove, Els C., Diamant, Michaela, Kramer, Mark H.H., Heine, Robert J., Maassen, J. Antonie, Slagboom, P. Eline, Willemsen, Gonneke, Dekker, Jacqueline M., Eekhoff, Elisabeth M., de Geus, Eco J., 't Hart, Leen M.
Publicado 2010

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps

por ‘t Hart, Leen M., Simonis-Bik, Annemarie M., Nijpels, Giel, van Haeften, Timon W., Schäfer, Silke A., Houwing-Duistermaat, Jeanine J., Boomsma, Dorret I., Groenewoud, Marlous J., Reiling, Erwin, van Hove, Els C., Diamant, Michaela, Kramer, Mark H.H., Heine, Robert J., Maassen, J. Antonie, Kirchhoff, Kerstin, Machicao, Fausto, Häring, Hans-Ulrich, Slagboom, P. Eline, Willemsen, Gonneke, Eekhoff, Elisabeth M., de Geus, Eco J., Dekker, Jacqueline M., Fritsche, Andreas
Publicado 2010

Genetic association analysis of LARS2 with type 2 diabetes

por Reiling, E., Jafar-Mohammadi, B., van ’t Riet, E., Weedon, M. N., van Vliet-Ostaptchouk, J. V., Hansen, T., Saxena, R., van Haeften, T. W., Arp, P. A., Das, S., Nijpels, G., Groenewoud, M. J., van Hove, E. C., Uitterlinden, A. G., Smit, J. W. A., Morris, A. D., Doney, A. S. F., Palmer, C. N. A., Guiducci, C., Hattersley, A. T., Frayling, T. M., Pedersen, O., Slagboom, P. E., Altshuler, D. M., Groop, L., Romijn, J. A., Maassen, J. A., Hofker, M. H., Dekker, J. M., McCarthy, M. I., ’t Hart, L. M.
Publicado 2009

The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway

por ‘t Hart, Leen M., Fritsche, Andreas, Nijpels, Giel, van Leeuwen, Nienke, Donnelly, Louise A., Dekker, Jacqueline M., Alssema, Marjan, Fadista, Joao, Carlotti, Françoise, Gjesing, Anette P., Palmer, Colin N.A., van Haeften, Timon W., Herzberg-Schäfer, Silke A., Simonis-Bik, Annemarie M.C., Houwing-Duistermaat, Jeanine J., Helmer, Quinta, Deelen, Joris, Guigas, Bruno, Hansen, Torben, Machicao, Fausto, Willemsen, Gonneke, Heine, Robert J., Kramer, Mark H.H., Holst, Jens J., de Koning, Eelco J.P., Häring, Hans-Ulrich, Pedersen, Oluf, Groop, Leif, de Geus, Eco J.C., Slagboom, P. Eline, Boomsma, Dorret I., Eekhoff, Elisabeth M.W., Pearson, Ewan R., Diamant, Michaela
Publicado 2013

Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

por van Vliet-Ostaptchouk, Jana V., van Haeften, Timon W., Landman, Gijs W. D., Reiling, Erwin, Kleefstra, Nanne, Bilo, Henk J. G., Klungel, Olaf H., de Boer, Anthonius, van Diemen, Cleo C., Wijmenga, Cisca, Boezen, H. Marike, Dekker, Jacqueline M., van 't Riet, Esther, Nijpels, Giel, Welschen, Laura M. C., Zavrelova, Hata, Bruin, Elinda J., Elbers, Clara C., Bauer, Florianne, Onland-Moret, N. Charlotte, van der Schouw, Yvonne T., Grobbee, Diederick E., Spijkerman, Annemieke M. W., van der A, Daphne L., Simonis-Bik, Annemarie M., Eekhoff, Elisabeth M. W., Diamant, Michaela, Kramer, Mark H. H., Boomsma, Dorret I., de Geus, Eco J., Willemsen, Gonneke, Slagboom, P. Eline, Hofker, Marten H., 't Hart, Leen M.
Publicado 2012

Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

por van Vliet-Ostaptchouk, Jana V., van Haeften, Timon W., Landman, Gijs W. D., Reiling, Erwin, Kleefstra, Nanne, Bilo, Henk J. G., Klungel, Olaf H., de Boer, Anthonius, van Diemen, Cleo C., Wijmenga, Cisca, Boezen, H. Marike, Dekker, Jacqueline M., van 't Riet, Esther, Nijpels, Giel, Welschen, Laura M. C., Zavrelova, Hata, Bruin, Elinda J., Elbers, Clara C., Bauer, Florianne, Onland-Moret, N. Charlotte, van der Schouw, Yvonne T., Grobbee, Diederick E., Spijkerman, Annemieke M. W., van der A, Daphne L., Simonis-Bik, Annemarie M., Eekhoff, Elisabeth M. W., Diamant, Michaela, Kramer, Mark H. H., Boomsma, Dorret I., de Geus, Eco J., Willemsen, Gonneke, Slagboom, P. Eline, Hofker, Marten H., 't Hart, Leen M.
Publicado 2012

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

por Wood, Andrew R., Jonsson, Anna, Jackson, Anne U., Wang, Nan, van Leewen, Nienke, Palmer, Nicholette D., Kobes, Sayuko, Deelen, Joris, Boquete-Vilarino, Lorena, Paananen, Jussi, Stančáková, Alena, Boomsma, Dorret I., de Geus, Eco J.C., Eekhoff, Elisabeth M.W., Fritsche, Andreas, Kramer, Mark, Nijpels, Giel, Simonis-Bik, Annemarie, van Haeften, Timon W., Mahajan, Anubha, Boehnke, Michael, Bergman, Richard N., Tuomilehto, Jaakko, Collins, Francis S., Mohlke, Karen L., Banasik, Karina, Groves, Christopher J., McCarthy, Mark I., Pearson, Ewan R., Natali, Andrea, Mari, Andrea, Buchanan, Thomas A., Taylor, Kent D., Xiang, Anny H., Gjesing, Anette P., Grarup, Niels, Eiberg, Hans, Pedersen, Oluf, Chen, Yii-Derr, Laakso, Markku, Norris, Jill M., Smith, Ulf, Wagenknecht, Lynne E., Baier, Leslie, Bowden, Donald W., Hansen, Torben, Walker, Mark, Watanabe, Richard M., ‘t Hart, Leen M., Hanson, Robert L., Frayling, Timothy M.
Publicado 2017