Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features

por Nguyen, Luan, Van Hoeck, Arne, Cuppen, Edwin
Publicado 2022

The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time

por Rosendahl Huber, Axel, Van Hoeck, Arne, Van Boxtel, Ruben
Publicado 2021

Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

por Kuijk, Ewart, Kranenburg, Onno, Cuppen, Edwin, Van Hoeck, Arne
Publicado 2022

Portrait of a cancer: mutational signature analyses for cancer diagnostics

por Van Hoeck, Arne, Tjoonk, Niels H., van Boxtel, Ruben, Cuppen, Edwin
Publicado 2019

Pan-cancer landscape of homologous recombination deficiency

por Nguyen, Luan, W. M. Martens, John, Van Hoeck, Arne, Cuppen, Edwin
Publicado 2020

The first draft genome of the aquatic model plant Lemna minor opens the route for future stress physiology research and biotechnological applications

por Van Hoeck, Arne, Horemans, Nele, Monsieurs, Pieter, Cao, Hieu Xuan, Vandenhove, Hildegarde, Blust, Ronny
Publicado 2015

β-Radiation Stress Responses on Growth and Antioxidative Defense System in Plants: A Study with Strontium-90 in Lemna minor

por Van Hoeck, Arne, Horemans, Nele, Van Hees, May, Nauts, Robin, Knapen, Dries, Vandenhove, Hildegarde, Blust, Ronny
Publicado 2015

Pan-cancer whole-genome comparison of primary and metastatic solid tumours

por Martínez-Jiménez, Francisco, Movasati, Ali, Brunner, Sascha Remy, Nguyen, Luan, Priestley, Peter, Cuppen, Edwin, Van Hoeck, Arne
Publicado 2023

The genome-wide mutational consequences of DNA hypomethylation

por Besselink, Nicolle, Keijer, Janneke, Vermeulen, Carlo, Boymans, Sander, de Ridder, Jeroen, van Hoeck, Arne, Cuppen, Edwin, Kuijk, Ewart
Publicado 2023

GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing

por Cameron, Daniel L., Baber, Jonathan, Shale, Charles, Valle-Inclan, Jose Espejo, Besselink, Nicolle, van Hoeck, Arne, Janssen, Roel, Cuppen, Edwin, Priestley, Peter, Papenfuss, Anthony T.
Publicado 2021

Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision Oncology

por van der Wiel, Alexander M. A., Schuitmaker, Lesley, Cong, Ying, Theys, Jan, Van Hoeck, Arne, Vens, Conchita, Lambin, Philippe, Yaromina, Ala, Dubois, Ludwig J.
Publicado 2022

The mutational impact of culturing human pluripotent and adult stem cells

por Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin
Publicado 2020

Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells

por Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin
Publicado 2020

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

por Christensen, Sharon, Van der Roest, Bastiaan, Besselink, Nicolle, Janssen, Roel, Boymans, Sander, Martens, John W. M., Yaspo, Marie-Laure, Priestley, Peter, Kuijk, Ewart, Cuppen, Edwin, Van Hoeck, Arne
Publicado 2019

MutationalPatterns: the one stop shop for the analysis of mutational processes

por Manders, Freek, Brandsma, Arianne M., de Kanter, Jurrian, Verheul, Mark, Oka, Rurika, van Roosmalen, Markus J., van der Roest, Bastiaan, van Hoeck, Arne, Cuppen, Edwin, van Boxtel, Ruben
Publicado 2022

Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer

por de Witte, Chris J., Kutzera, Joachim, van Hoeck, Arne, Nguyen, Luan, Boere, Ingrid A., Jalving, Mathilde, Ottevanger, Petronella B., van Schaik-van de Mheen, Christa, Stevense, Marion, Kloosterman, Wigard P., Zweemer, Ronald P., Cuppen, Edwin, Witteveen, Petronella O.
Publicado 2022

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

por Demmers, Laura C., Kretzschmar, Kai, Van Hoeck, Arne, Bar-Epraïm, Yotam E., van den Toorn, Henk W. P., Koomen, Mandy, van Son, Gijs, van Gorp, Joost, Pronk, Apollo, Smakman, Niels, Cuppen, Edwin, Clevers, Hans, Heck, Albert J. R., Wu, Wei
Publicado 2020

Pan-cancer whole-genome analyses of metastatic solid tumours

por Priestley, Peter, Baber, Jonathan, Lolkema, Martijn P., Steeghs, Neeltje, de Bruijn, Ewart, Shale, Charles, Duyvesteyn, Korneel, Haidari, Susan, van Hoeck, Arne, Onstenk, Wendy, Roepman, Paul, Voda, Mircea, Bloemendal, Haiko J., Tjan-Heijnen, Vivianne C. G., van Herpen, Carla M. L., Labots, Mariette, Witteveen, Petronella O., Smit, Egbert F., Sleijfer, Stefan, Voest, Emile E., Cuppen, Edwin
Publicado 2019

Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests

por Meijer, Titia G., Nguyen, Luan, Van Hoeck, Arne, Sieuwerts, Anieta M., Verkaik, Nicole S., Ladan, Marjolijn M., Ruigrok-Ritstier, Kirsten, van Deurzen, Carolien H. M., van de Werken, Harmen J. G., Lips, Esther H., Linn, Sabine C., Memari, Yasin, Davies, Helen, Nik-Zainal, Serena, Kanaar, Roland, Martens, John W. M., Cuppen, Edwin, Jager, Agnes, van Gent, Dik C.
Publicado 2022

Long‐term expanding human airway organoids for disease modeling

por Sachs, Norman, Papaspyropoulos, Angelos, Zomer‐van Ommen, Domenique D, Heo, Inha, Böttinger, Lena, Klay, Dymph, Weeber, Fleur, Huelsz‐Prince, Guizela, Iakobachvili, Nino, Amatngalim, Gimano D, de Ligt, Joep, van Hoeck, Arne, Proost, Natalie, Viveen, Marco C, Lyubimova, Anna, Teeven, Luc, Derakhshan, Sepideh, Korving, Jeroen, Begthel, Harry, Dekkers, Johanna F, Kumawat, Kuldeep, Ramos, Emilio, van Oosterhout, Matthijs FM, Offerhaus, G Johan, Wiener, Dominique J, Olimpio, Eduardo P, Dijkstra, Krijn K, Smit, Egbert F, van der Linden, Maarten, Jaksani, Sridevi, van de Ven, Marieke, Jonkers, Jos, Rios, Anne C, Voest, Emile E, van Moorsel, Coline HM, van der Ent, Cornelis K, Cuppen, Edwin, van Oudenaarden, Alexander, Coenjaerts, Frank E, Meyaard, Linde, Bont, Louis J, Peters, Peter J, Tans, Sander J, van Zon, Jeroen S, Boj, Sylvia F, Vries, Robert G, Beekman, Jeffrey M, Clevers, Hans
Publicado 2019