How mRNA therapeutics are entering the monoclonal antibody field

por Van Hoecke, Lien, Roose, Kenny
Publicado 2019

Therapeutic anti-tumor immunity directed against neo-epitopes by intratumor delivery of mRNA encoding MLKL

por Van Hoecke, Lien, Saelens, Xavier
Publicado 2018

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

por Xie, Junhua, Van Hoecke, Lien, Vandenbroucke, Roosmarijn E.
Publicado 2022

Recent insights into viral infections as a trigger and accelerator in alzheimer's disease

por De Vlieger, Lize, Vandenbroucke, Roosmarijn E., Van Hoecke, Lien
Publicado 2022

Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice

por Van Hoecke, Lien, Riederer, Stephanie, Saelens, Xavier, Sutter, Gerd, Rojas, Juan J.
Publicado 2020

mRNA in cancer immunotherapy: beyond a source of antigen

por Van Hoecke, Lien, Verbeke, Rein, Dewitte, Heleen, Lentacker, Ine, Vermaelen, Karim, Breckpot, Karine, Van Lint, Sandra
Publicado 2021

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

por Van Hoecke, Lien, Roose, Kenny, Ballegeer, Marlies, Zhong, Zifu, Sanders, Niek N., De Koker, Stefaan, Saelens, Xavier, Van Lint, Sandra
Publicado 2020

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

por Joe, Patrick Tjok, Christopoulou, Ioanna, van Hoecke, Lien, Schepens, Bert, Ysenbaert, Tine, Heirman, Carlo, Thielemans, Kris, Saelens, Xavier, Aerts, Joeri L.
Publicado 2019

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

por Van Hoecke, Lien, Van Lint, Sandra, Roose, Kenny, Van Parys, Alexander, Vandenabeele, Peter, Grooten, Johan, Tavernier, Jan, De Koker, Stefaan, Saelens, Xavier
Publicado 2018

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells

por Van Hoecke, Lien, Raes, Laurens, Stremersch, Stephan, Brans, Toon, Fraire, Juan C., Roelandt, Ria, Declercq, Wim, Vandenabeele, Peter, Raemdonck, Koen, Braeckmans, Kevin, Saelens, Xavier
Publicado 2019

Specific targeting of IL-1β activity to CD8(+) T cells allows for safe use as a vaccine adjuvant

por Van Den Eeckhout, Bram, Van Hoecke, Lien, Burg, Elianne, Van Lint, Sandra, Peelman, Frank, Kley, Niko, Uzé, Gilles, Saelens, Xavier, Tavernier, Jan, Gerlo, Sarah
Publicado 2020

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

por Van den Hoecke, Silvie, Ballegeer, Marlies, Vrancken, Bram, Deng, Lei, Job, Emma R., Roose, Kenny, Schepens, Bert, Van Hoecke, Lien, Lemey, Philippe, Saelens, Xavier
Publicado 2021

The neurogliovascular unit in hepatic encephalopathy

por Claeys, Wouter, Van Hoecke, Lien, Lefere, Sander, Geerts, Anja, Verhelst, Xavier, Van Vlierberghe, Hans, Degroote, Helena, Devisscher, Lindsey, Vandenbroucke, Roosmarijn E., Van Steenkiste, Christophe
Publicado 2021

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection

por De Vlieger, Dorien, Hoffmann, Katja, Van Molle, Inge, Nerinckx, Wim, Van Hoecke, Lien, Ballegeer, Marlies, Creytens, Sarah, Remaut, Han, Hengel, Hartmut, Schepens, Bert, Saelens, Xavier
Publicado 2019

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

por Van Hoecke, Lien, Verbeke, Rein, De Vlieger, Dorien, Dewitte, Heleen, Roose, Kenny, Van Nevel, Sharon, Krysko, Olga, Bachert, Claus, Schepens, Bert, Lentacker, Ine, Saelens, Xavier
Publicado 2020

A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation

por Claeys, Wouter, Van Hoecke, Lien, Geerts, Anja, Van Vlierberghe, Hans, Lefere, Sander, Van Imschoot, Griet, Van Wonterghem, Elien, Ghesquière, Bart, Vandenbroucke, Roosmarijn E., Van Steenkiste, Christophe
Publicado 2022

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

por Claeys, Wouter, Van Hoecke, Lien, Lernout, Hannah, De Nolf, Clint, Van Imschoot, Griet, Van Wonterghem, Elien, Verhaege, Daan, Castelein, Jonas, Geerts, Anja, Van Steenkiste, Christophe, Vandenbroucke, Roosmarijn E.
Publicado 2023

Cholesterol‐sensing liver X receptors stimulate Th2‐driven allergic eosinophilic asthma in mice

por Smet, Muriel, Van Hoecke, Lien, De Beuckelaer, Ans, Vander Beken, Seppe, Naessens, Thomas, Vergote, Karl, Willart, Monique, Lambrecht, Bart N., Gustafsson, Jan‐Åke, Steffensen, Knut R., Grooten, Johan
Publicado 2016

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer’s disease

por Xie, Junhua, Gorlé, Nina, Vandendriessche, Charysse, Van Imschoot, Griet, Van Wonterghem, Elien, Van Cauwenberghe, Caroline, Parthoens, Eef, Van Hamme, Evelien, Lippens, Saskia, Van Hoecke, Lien, Vandenbroucke, Roosmarijn E.
Publicado 2021

Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann–Pick Type C Disease

por Van Hoecke, Lien, Van Cauwenberghe, Caroline, Börger, Verena, Bruggeman, Arnout, Castelein, Jonas, Van Imschoot, Griet, Van Wonterghem, Elien, Dittrich, Robin, Claeys, Wouter, Xie, Junhua, Giebel, Bernd, Vandenbroucke, Roosmarijn E.
Publicado 2021