Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis

por Nijhuis, Lotte, Peeters, Janneke G. C., Vastert, Sebastiaan J., van Loosdregt, Jorg
Publicado 2019

Review: Enhancers in Autoimmune Arthritis: Implications and Therapeutic Potential

por Peeters, Janneke G. C., Vastert, Sebastiaan J., van Wijk, Femke, van Loosdregt, Jorg
Publicado 2017

Tissue–Resident Memory T Cells in Chronic Inflammation—Local Cells with Systemic Effects?

por Samat, Anoushka Ashok Kumar, van der Geest, Jolijn, Vastert, Sebastiaan J., van Loosdregt, Jorg, van Wijk, Femke
Publicado 2021

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

por van Loosdregt, Jorg, Brunen, Diede, Fleskens, Veerle, Pals, Cornelieke E. G. M., Lam, Eric W. F., Coffer, Paul J.
Publicado 2011

NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA

por Rajendiran, Anandhi, Subramanyam, Sudheendra Hebbar, Klemm, Patricia, Jankowski, Vera, van Loosdregt, Jorg, Vastert, Bas, Vollbach, Kristina, Wagner, Norbert, Tenbrock, Klaus, Ohl, Kim
Publicado 2022

Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

por Lutter, Lisanne, van der Wal, M Marlot, Brand, Eelco C, Maschmeyer, Patrick, Vastert, Sebastiaan, Mashreghi, Mir‐Farzin, van Loosdregt, Jorg, van Wijk, Femke
Publicado 2022

A circulating reservoir of pathogenic-like CD4(+) T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment

por Spreafico, Roberto, Rossetti, Maura, van Loosdregt, Jorg, Wallace, Carol A, Massa, Margherita, Magni-Manzoni, Silvia, Gattorno, Marco, Martini, Alberto, Lovell, Daniel J, Albani, Salvatore
Publicado 2016

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

por Peeters, Janneke G C, Boltjes, Arjan, Scholman, Rianne C, Vervoort, Stephin J, Coffer, Paul J, Mokry, Michal, Vastert, Sebastiaan J, van Wijk, Femke, van Loosdregt, Jorg
Publicado 2023

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

por Hooikaas, Peter Jan, Damstra, Hugo GJ, Gros, Oane J, van Riel, Wilhelmina E, Martin, Maud, Smits, Yesper TH, van Loosdregt, Jorg, Kapitein, Lukas C, Berger, Florian, Akhmanova, Anna
Publicado 2020

Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis

por Boltjes, Arjan, Samat, Anoushka Ashok Kumar, Plantinga, Maud, Mokry, Michal, Castelijns, Bas, Swart, Joost F., Vastert, Sebastiaan J., Creyghton, Menno, Nierkens, Stefan, van Loosdregt, Jorg, van Wijk, Femke
Publicado 2023

Autoimmune disease-associated gene expression is reduced by BET-inhibition

por Peeters, Janneke G.C., Vervoort, Stephin J., Mijnheer, Gerdien, de Roock, Sytze, Vastert, Sebastiaan J., Nieuwenhuis, Edward E.S., van Wijk, Femke, Prakken, Berent J., Mokry, Michal, van Loosdregt, Jorg
Publicado 2015

N(6)-Methyladenosine Directly Regulates CD40L Expression in CD4(+) T Lymphocytes

por van Vroonhoven, Ellen C. N., Picavet, Lucas W., Scholman, Rianne C., van den Dungen, Noortje A. M., Mokry, Michal, Evers, Anouk, Lebbink, Robert J., Calis, Jorg J. A., Vastert, Sebastiaan J., van Loosdregt, Jorg
Publicado 2023

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

por Mijnheer, Gerdien, Lutter, Lisanne, Mokry, Michal, van der Wal, Marlot, Scholman, Rianne, Fleskens, Veerle, Pandit, Aridaman, Tao, Weiyang, Wekking, Mark, Vervoort, Stephin, Roberts, Ceri, Petrelli, Alessandra, Peeters, Janneke G. C., Knijff, Marthe, de Roock, Sytze, Vastert, Sebastiaan, Taams, Leonie S., van Loosdregt, Jorg, van Wijk, Femke
Publicado 2021

Treatment to Target Using Recombinant Interleukin‐1 Receptor Antagonist as First‐Line Monotherapy in New‐Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five‐Year Foll...

por ter Haar, Nienke M., van Dijkhuizen, E. H. Pieter, Swart, Joost F., van Royen‐Kerkhof, Annet, el Idrissi, Ayman, Leek, Arjen P., de Jager, Wilco, de Groot, Mark C. H., Haitjema, Saskia, Holzinger, Dirk, Foell, Dirk, van Loosdregt, Jorg, Wulffraat, Nico M., de Roock, Sytze, Vastert, Sebastiaan J.
Publicado 2019

Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis

por Verwoerd, Anouk, Armbrust, Wineke, Cowan, Katherine, van den Berg, Lotte, de Boer, Joke, Bookelman, Sanne, Britstra, Marjan, Cappon, Jeannette, Certan, Maria, Dedding, Christine, van den Haspel, Karin, Muller, Petra Hissink, Jongsma, Karin, Lelieveld, Otto, van Loosdregt, Jorg, Olsder, Wendy, Rocha, Johanna, Schatorjé, Ellen, Schouten, Natasja, Swart, Joost F., Vastert, Sebastiaan, Walter, Margot, Schoemaker, Casper G.
Publicado 2021

Dutch juvenile idiopathic arthritis patients, carers and clinicians create a research agenda together following the James Lind Alliance method: a study protocol

por Schoemaker, Casper G., Armbrust, Wineke, Swart, Joost F., Vastert, Sebastiaan J., van Loosdregt, Jorg, Verwoerd, Anouk, Whiting, Caroline, Cowan, Katherine, Olsder, Wendy, Versluis, Els, van Vliet, Rens, Fernhout, Marlous J., Bookelman, Sanne L., Cappon, Jeannette, van den Berg, J. Merlijn, Schatorjé, Ellen, Muller, Petra C. E. Hissink, Kamphuis, Sylvia, de Boer, Joke, Lelieveld, Otto T. H. M., van der Net, Janjaap, Jongsma, Karin R., van Rensen, Annemiek, Dedding, Christine, Wulffraat, Nico M.
Publicado 2018