Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation

por Zara, Lorena, Moraca, Francesca, Van Muijlwijk-Koezen, Jacqueline E., Zarzycka, Barbara, Abel, Robert, de Esch, Iwan J. P.
Publicado 2022

Design, Synthesis, and Structure–Activity Relationships of Highly Potent 5-HT(3) Receptor Ligands

por Verheij, Mark H. P., Thompson, Andrew J., van Muijlwijk-Koezen, Jacqueline E., Lummis, Sarah C. R., Leurs, Rob, de Esch, Iwan J. P.
Publicado 2012

Structure–Activity Relationships of Quinoxaline-Based 5-HT(3)A and 5-HT(3)AB Receptor-Selective Ligands

por Thompson, Andrew J, Verheij, Mark H P, van Muijlwijk-Koezen, Jacqueline E, Lummis, Sarah C R, Leurs, Rob, de Esch, Iwan J P
Publicado 2013

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

por FitzGerald, Edward A., Butko, Margaret T., Boronat, Pierre, Cederfelt, Daniela, Abramsson, Mia, Ludviksdottir, Hildur, van Muijlwijk-Koezen, Jacqueline E., de Esch, Iwan J. P., Dobritzsch, Doreen, Young, Tracy, Danielson, U. Helena
Publicado 2021

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H(4) and the ion channel serotonin 5-HT(3A)

por Verheij, Mark H.P., de Graaf, Chris, de Kloe, Gerdien E., Nijmeijer, Saskia, Vischer, Henry F., Smits, Rogier A., Zuiderveld, Obbe P., Hulscher, Saskia, Silvestri, Linda, Thompson, Andrew J., van Muijlwijk-Koezen, Jacqueline E., Lummis, Sarah C.R., Leurs, Rob, de Esch, Iwan J.P.
Publicado 2011