In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressin...

por Hinrichs, Anneline C., Kruize, Aike A., Leavis, Helen L., van Roon, Joel A. G.
Publicado 2022

CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren’s Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells

por Hinrichs, Anneline C., Kruize, Aike A., Lafeber, Floris P. J. G., Leavis, Helen L., van Roon, Joel A. G.
Publicado 2023

CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

por Hinrichs, Anneline C., Blokland, Sofie L. M., Kruize, Aike A., Lafeber, Floris P. J., Leavis, Helen L., van Roon, Joel A. G.
Publicado 2022

Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren’s syndrome to...

por Blokland, Sofie L. M., Kislat, Andreas, Homey, Bernhard, Smithson, Glennda M., Kruize, Aike A., Radstake, Timothy R. D. J., van Roon, Joel A. G.
Publicado 2019

Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome sc...

por van den Hoogen, Lucas L, Palla, Giovanni, Bekker, Cornelis P J, Fritsch-Stork, Ruth D E, Radstake, Timothy R D J, van Roon, Joel A G
Publicado 2018

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

por Hillen, Maarten R., Hartgring, Sarita A. Y., Willis, Cynthia R., Radstake, Timothy R. D. J., Hack, Cornelis E., Lafeber, Floris P. J. G., van Roon, Joel A. G
Publicado 2015

Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients

por Carvalheiro, Tiago, Horta, Sara, van Roon, Joel A. G., Santiago, Mariana, Salvador, Maria J., Trindade, Hélder, Radstake, Timothy R. D. J., da Silva, José A. P., Paiva, Artur
Publicado 2017

CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis

por Affandi, Alsya J., Silva‐Cardoso, Sandra C., Garcia, Samuel, Leijten, Emmerik F. A., van Kempen, Tessa S., Marut, Wioleta, van Roon, Joel A. G., Radstake, Timothy R. D. J.
Publicado 2018

Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren’s Syndrome Patients Identifies CCL5 as a Novel Effector Molecule

por Hinrichs, Anneline C., Blokland, Sofie L. M., Lopes, Ana P., Wichers, Catharina G. K., Kruize, Aike A., Pandit, Aridaman, Radstake, Timothy R. D. J., van Roon, Joel A. G.
Publicado 2021

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren’s syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

por Blokland, Sofie L M, Hillen, Maarten R, Wichers, Catharina G K, Zimmermann, Maili, Kruize, Aike A, Radstake, Timothy R D J, Broen, Jasper C A, van Roon, Joel A G
Publicado 2019

Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren’s syndrome

por Lopes, Ana P., Hillen, Maarten R., Chouri, Eleni, Blokland, Sofie L. M., Bekker, Cornelis P. J., Kruize, Aike A., Rossato, Marzia, van Roon, Joel A. G., Radstake, Timothy R. D. J.
Publicado 2018

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I...

por Hillen, Maarten R, Urso, Katia, Koppe, Emma, Lopes, Ana Pinheiro, Blokland, Sofie L M, Pandit, Aridaman, Slocombe, Tom, van Maurik, André, van Roon, Joel A G, Radstake, Timothy R D J
Publicado 2020

Interleukin-7 and Toll-Like Receptor 7 Induce Synergistic B Cell and T Cell Activation

por Bikker, Angela, Kruize, Aike A., van der Wurff-Jacobs, Kim M. G., Peters, Rogier P., Kleinjan, Marije, Redegeld, Frank, de Jager, Wilco, Lafeber, Floris P. J. G., van Roon, Joël A. G.
Publicado 2014

Salivary gland secretome: a novel tool towards molecular stratification of patients with primary Sjögren’s syndrome and non-autoimmune sicca

por Blokland, Sofie L M, Hillen, Maarten R, van Vliet-Moret, Fréderique M, Bikker, Angela, de Jager, Wilco, Pandit, Aridaman, Kruize, Aike A, Radstake, Timothy R D J, van Roon, Joel A G
Publicado 2019

The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators

por Lopes, Ana P., Bekker, Cornelis P. J., Hillen, Maarten R., Blokland, Sofie L. M., Hinrichs, Anneline C., Pandit, Aridaman, Kruize, Aike A., Radstake, Timothy R. D. J., van Roon, Joel A. G.
Publicado 2021

Dysregulated miRNome of plasmacytoid dendritic cells from patients with Sjögren’s syndrome is associated with processes at the centre of their function

por Hillen, Maarten R, Chouri, Eleni, Wang, Maojie, Blokland, Sofie L M, Hartgring, Sarita A Y, Concepcion, Arno N, Kruize, Aike A, Burgering, Boudewijn M T, Rossato, Marzia, van Roon, Joel A G, Radstake, Timothy R D J
Publicado 2019

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopath...

por Blokland, Sofie L M, van Vliet-Moret, Fréderique M, Hillen, Maarten R, Pandit, Aridaman, Goldschmeding, Roel, Kruize, Aike A, Bouma, Gerben, van Maurik, André, Olek, Sven, Hoffmueller, Ulrich, van Roon, Joel A G, Radstake, Timothy R D J
Publicado 2020

Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study

por Bakker, Marije F, Cavet, Guy, Jacobs, Johannes WG, Bijlsma, Johannes W J, Haney, Douglas J, Shen, Yijing, Hesterberg, Lyndal K, Smith, Dustin R, Centola, Michael, van Roon, Joel A G, Lafeber, Floris P J G, Welsing, Paco M J
Publicado 2012

Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production

por Hillen, Maarten R., Pandit, Aridaman, Blokland, Sofie L. M., Hartgring, Sarita A. Y., Bekker, Cornelis P. J., van der Heijden, Eefje H. M., Servaas, Nila H., Rossato, Marzia, Kruize, Aike A., van Roon, Joel A. G., Radstake, Timothy R. D. J.
Publicado 2019

MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1

por Lopes, Ana P., van Roon, Joel A. G., Blokland, Sofie L. M., Wang, Maojie, Chouri, Eleni, Hartgring, Sarita A. Y., van der Wurff-Jacobs, Kim M. G., Kruize, Aike A., Burgering, Boudewijn M. T., Rossato, Marzia, Radstake, Timothy R. D. J., Hillen, Maarten R.
Publicado 2019