Epigenetic Changes and Chromatin Reorganization in Brain Function: Lessons from Fear Memory Ensemble and Alzheimer’s Disease

por van Zundert, Brigitte, Montecino, Martin
Publicado 2022

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

por Rojas, Fabiola, Cortes, Nicole, Abarzua, Sebastian, Dyrda, Agnieszka, van Zundert, Brigitte
Publicado 2014

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

por Gonzalez, David, Contreras, Osvaldo, Rebolledo, Daniela L., Espinoza, Juan Pablo, van Zundert, Brigitte, Brandan, Enrique
Publicado 2017

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions

por Harcha, Paloma A., Garcés, Polett, Arredondo, Cristian, Fernández, Germán, Sáez, Juan C., van Zundert, Brigitte
Publicado 2021

Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124

por Guajardo, Laura, Aguilar, Rodrigo, Bustos, Fernando J., Nardocci, Gino, Gutiérrez, Rodrigo A., van Zundert, Brigitte, Montecino, Martin
Publicado 2020

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological...

por Quezada, Esteban, Cappelli, Claudio, Diaz, Iván, Jury, Nur, Wightman, Nicholas, Brown, Robert H., Montecino, Martín, van Zundert, Brigitte
Publicado 2021

H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus

por Guerra, Miguel V., Cáceres, Matías I., Herrera-Soto, Andrea, Arredondo, Sebastián B., Varas-Godoy, Manuel, van Zundert, Brigitte, Varela-Nallar, Lorena
Publicado 2022

Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

por Rojas, Fabiola, Gonzalez, David, Cortes, Nicole, Ampuero, Estibaliz, Hernández, Diego E., Fritz, Elsa, Abarzua, Sebastián, Martinez, Alexis, Elorza, Alvaro A., Alvarez, Alejandra, Court, Felipe, van Zundert, Brigitte
Publicado 2015

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors

por Bustos, Fernando J., Varela-Nallar, Lorena, Campos, Matias, Henriquez, Berta, Phillips, Marnie, Opazo, Carlos, Aguayo, Luis G., Montecino, Martin, Constantine-Paton, Martha, Inestrosa, Nibaldo C., van Zundert, Brigitte
Publicado 2014

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

por Jury, Nur, Abarzua, Sebastian, Diaz, Ivan, Guerra, Miguel V., Ampuero, Estibaliz, Cubillos, Paula, Martinez, Pablo, Herrera-Soto, Andrea, Arredondo, Cristian, Rojas, Fabiola, Manterola, Marcia, Rojas, Adriana, Montecino, Martín, Varela-Nallar, Lorena, van Zundert, Brigitte
Publicado 2020

Protein kinase B (AKT) upregulation and Thy-1-α(v)β(3) integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis

por Pérez-Núñez, Ramón, Chamorro, Alejandro, González, María Fernanda, Contreras, Pamela, Artigas, Rocío, Corvalán, Alejandro H., van Zundert, Brigitte, Reyes, Christopher, Moya, Pablo R., Avalos, Ana María, Schneider, Pascal, Quest, Andrew F. G., Leyton, Lisette
Publicado 2023

α(V)β(3) Integrin regulates astrocyte reactivity

por Lagos-Cabré, Raúl, Alvarez, Alvaro, Kong, Milene, Burgos-Bravo, Francesca, Cárdenas, Areli, Rojas-Mancilla, Edgardo, Pérez-Nuñez, Ramón, Herrera-Molina, Rodrigo, Rojas, Fabiola, Schneider, Pascal, Herrera-Marschitz, Mario, Quest, Andrew F. G., van Zundert, Brigitte, Leyton, Lisette
Publicado 2017

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43( A90V ) mutation display a mild reactive state and release polyP toxic to motoneurons

por Rojas, Fabiola, Aguilar, Rodrigo, Almeida, Sandra, Fritz, Elsa, Corvalán, Daniela, Ampuero, Estibaliz, Abarzúa, Sebastián, Garcés, Polett, Amaro, Armando, Diaz, Iván, Arredondo, Cristian, Cortes, Nicole, Sanchez, Mario, Mercado, Constanza, Varela-Nallar, Lorena, Gao, Fen-Biao, Montecino, Martin, van Zundert, Brigitte
Publicado 2023

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration

por Martinez, Alexis, Lamaizon, Cristian M., Valls, Cristian, Llambi, Fabien, Leal, Nancy, Fitzgerald, Patrick, Guy, Cliff, Kamiński, Marcin M., Inestrosa, Nibaldo C., van Zundert, Brigitte, Cancino, Gonzalo I., Dulcey, Andrés E., Zanlungo, Silvana, Marugan, Juan J., Hetz, Claudio, Green, Douglas R., Alvarez, Alejandra R.
Publicado 2023