Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

por Syvänen, Stina, Schenke, Maarten, van den Berg, Dirk-Jan, Voskuyl, Rob A., de Lange, Elizabeth C.
Publicado 2012

Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain

por Kervezee, Laura, Hartman, Robin, van den Berg, Dirk-Jan, Shimizu, Shinji, Emoto-Yamamoto, Yumi, Meijer, Johanna H., de Lange, Elizabeth C. M.
Publicado 2014

Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D (2) receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling

por van den Brink, Willem J, van den Berg, Dirk‐Jan, Bonsel, Floor E M, Hartman, Robin, Wong, Yin‐Cheong, van der Graaf, Piet H, de Lange, Elizabeth C M
Publicado 2018

Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial

por Lebedev, Alexander V., Nilsson, Jonna, Lindström, Joanna, Fredborg, William, Akenine, Ulrika, Hillilä, Carolina, Andersen, Pia, Spulber, Gabriela, de Lange, Elizabeth C. M., van den Berg, Dirk-Jan, Kivipelto, Miia, Lövdén, Martin
Publicado 2020

Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain

por van den Brink, Willem J., Hartman, Robin, van den Berg, Dirk‐Jan, Flik, Gunnar, Gonzalez‐Amoros, Belén, Koopman, Nanda, Elassais‐Schaap, Jeroen, van der Graaf, Piet Hein, Hankemeier, Thomas, de Lange, Elizabeth C.M.
Publicado 2019

Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

por van Wijk, Rob C., Hu, Wanbin, Dijkema, Sharka M., van den Berg, Dirk‐Jan, Liu, Jeremy, Bahi, Rida, Verbeek, Fons J., Simonsson, Ulrika S.H., Spaink, Herman P., van der Graaf, Piet H., Krekels, Elke H.J.
Publicado 2020

Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

por Yamamoto, Yumi, Välitalo, Pyry A., Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Beukers, Margot W., van den Berg, Dirk‐Jan, Hartman, Robin, Wong, Yin Cheong, Danhof, Meindert, van Hasselt, John G. C., de Lange, Elizabeth C. M.
Publicado 2017

LUF7244, an allosteric modulator/activator of K(v)11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

por Qile, Muge, Beekman, Henriette D.M., Sprenkeler, David J., Houtman, Marien J.C., van Ham, Willem B., Stary‐Weinzinger, Anna, Beyl, Stanislav, Hering, Steffen, van den Berg, Dirk‐Jan, de Lange, Elizabeth C.M., Heitman, Laura H., IJzerman, Ad P., Vos, Marc A., van der Heyden, Marcel A.G.
Publicado 2019

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

por Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.
Publicado 2016