Quantitative analysis by next generation sequencing of hematopoietic stem and progenitor cells (LSK) and of splenic B cells transcriptomes from wild-type and Usp3-knockout mice

por Lancini, Cesare, Gargiulo, Gaetano, van den Berk, Paul C.M., Citterio, Elisabetta
Publicado 2016

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation

por Krijger, Peter H.L., Langerak, Petra, van den Berk, Paul C.M., Jacobs, Heinz
Publicado 2009

The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination

por Krijger, Peter H. L., Wit, Niek, van den Berk, Paul C. M., Jacobs, Heinz
Publicado 2010

Lysine Residue 185 of Rad1 Is a Topological but Not a Functional Counterpart of Lysine Residue 164 of PCNA

por Wit, Niek, Krijger, Peter H. L., van den Berk, Paul C. M., Jacobs, Heinz
Publicado 2011

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

por Jansen, Jacob G., Langerak, Petra, Tsaalbi-Shtylik, Anastasia, van den Berk, Paul, Jacobs, Heinz, de Wind, Niels
Publicado 2006

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice

por Langerak, Petra, Krijger, Peter H.L., Heideman, Marinus R., van den Berk, Paul C.M., Jacobs, Heinz
Publicado 2008

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNA(K164) modification

por Langerak, Petra, Nygren, Anders O.H., Krijger, Peter H.L., van den Berk, Paul C.M., Jacobs, Heinz
Publicado 2007

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

por Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Pritchard, Colin, Blomberg, Olga S., Huijbers, Ivo J., van den Berk, Paul C.M., Jacobs, Heinz
Publicado 2016

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype

por Shah, Ronak, van den Berk, Paul C. M., Pritchard, Colin E. J., Song, Ji-Ying, Kreft, Maaike, Pilzecker, Bas, Jacobs, Heinz
Publicado 2023

Differential Programming of B Cells in AID Deficient Mice

por Hogenbirk, Marc A., Heideman, Marinus R., Velds, Arno, van den Berk, Paul CM., Kerkhoven, Ron M., van Steensel, Bas, Jacobs, Heinz
Publicado 2013

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

por Wit, Niek, Buoninfante, Olimpia Alessandra, van den Berk, Paul C.M., Jansen, Jacob G., Hogenbirk, Marc A., de Wind, Niels, Jacobs, Heinz
Publicado 2015

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system

por Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C.M., Jacobs, Heinz
Publicado 2018

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

por Lancini, Cesare, van den Berk, Paul C.M., Vissers, Joseph H.A., Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta
Publicado 2014

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

por Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz
Publicado 2023

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

por Will Castro, Luiza S. E. P., Pieters, Wietske, Alemdehy, Mir Farshid, Aslam, Muhammad A., Buoninfante, Olimpia Alessandra, Raaijmakers, Jonne A., Pilzecker, Bas, van den Berk, Paul C. M., te Riele, Hein, Medema, René H., Pedrosa, Rozangela C., Jacobs, Heinz
Publicado 2021

The Ig heavy chain protein but not its message controls early B cell development

por Aslam, Muhammad Assad, Alemdehy, Mir Farshid, Hao, Bingtao, Krijger, Peter H. L., Pritchard, Colin E. J., de Rink, Iris, Muhaimin, Fitriari Izzatunnisa, Nurzijah, Ika, van Baalen, Martijn, Kerkhoven, Ron M., van den Berk, Paul C. M., Skok, Jane A., Jacobs, Heinz
Publicado 2020

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

por van den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Pritchard, Colin, Song, Ji-Ying, Schmitt, Matthias Jürgen, Tanger, Ellen, Popp, Oliver, Mertins, Philipp, Huijbers, Ivo J., Jacobs, Heinz, van Lohuizen, Maarten, Gargiulo, Gaetano, Citterio, Elisabetta
Publicado 2020

Mammalian life depends on two distinct pathways of DNA damage tolerance

por Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E. J., Vivié, Judith, Mcgrath, Kathleen E., Huijbers, Ivo J., Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L., Palis, James, van den Berk, Paul C. M., Jacobs, Heinz
Publicado 2023

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine

por Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz
Publicado 2022