Going -omics to identify novel therapeutic targets for cardiovascular disease

por Harber, Karl J., Verberk, Sanne G.S., Van den Bossche, Jan
Publicado 2019

Metabolic Cancer-Macrophage Crosstalk in the Tumor Microenvironment

por de Goede, Kyra E., Driessen, Amber J. M., Van den Bossche, Jan
Publicado 2020

Macrophages, PPARs, and Cancer

por Van Ginderachter, Jo A., Movahedi, Kiavash, Van den Bossche, Jan, De Baetselier, Patrick
Publicado 2008

On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity

por Backx, Elyne, Coolens, Katarina, Van den Bossche, Jan-Lars, Houbracken, Isabelle, Espinet, Elisa, Rooman, Ilse
Publicado 2021

Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages

por Maassen, Sjors, Coenen, Britt, Ioannidis, Melina, Harber, Karl, Grijpstra, Pieter, Van den Bossche, Jan, van den Bogaart, Geert
Publicado 2022

An integrated toolbox to profile macrophage immunometabolism

por Verberk, Sanne G.S., de Goede, Kyra E., Gorki, Friederike S., van Dierendonck, Xanthe A.M.H., Argüello, Rafael J., Van den Bossche, Jan
Publicado 2022

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

por Van den Bossche, Jan, Laoui, Damya, Naessens, Thomas, Smits, Hermelijn H., Hokke, Cornelis H., Stijlemans, Benoît, Grooten, Johan, De Baetselier, Patrick, Van Ginderachter, Jo A.
Publicado 2015

Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy

por Schetters, Sjoerd T T, Rodriguez, Ernesto, Kruijssen, Laura J W, Crommentuijn, Matheus H W, Boon, Louis, Van den Bossche, Jan, Den Haan, Joke M M, Van Kooyk, Yvette
Publicado 2020

Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth

por de Goede, Kyra E., Verberk, Sanne G. S., Baardman, Jeroen, Harber, Karl J., van Kooyk, Yvette, de Winther, Menno P. J., Schetters, Sjoerd T. T., Van den Bossche, Jan
Publicado 2021

Pancreatic acinar cell fate relies on system x(C)(-) to prevent ferroptosis during stress

por Pan, Zhaolong, Van den Bossche, Jan-Lars, Rodriguez-Aznar, Eva, Janssen, Pauline, Lara, Olaya, Ates, Gamze, Massie, Ann, De Paep, Diedert Luc, Houbracken, Isabelle, Mambretti, Marco, Rooman, Ilse
Publicado 2023

Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages

por Harber, Karl J., de Goede, Kyra E., Verberk, Sanne G. S., Meinster, Elisa, de Vries, Helga E., van Weeghel, Michel, de Winther, Menno P. J., Van den Bossche, Jan
Publicado 2020

α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming

por Lübbers, Joyce, Eveline Li, Rui-Jún, Gorki, Friederike S, Bruijns, Sven C M, Gallagher, Ashley, Kalay, Hakan, Ambrosini, Martino, Molenaar, Douwe, Van den Bossche, Jan, van Vliet, Sandra J, van Kooyk, Yvette
Publicado 2021

Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling

por Erkelens, Martje N., Goverse, Gera, Konijn, Tanja, Molenaar, Rosalie, Beijer, Marieke R., Van den Bossche, Jan, de Goede, Kyra E., Verberk, Sanne G. S., de Jonge, Wouter J., den Haan, Joke M. M., Mebius, Reina E.
Publicado 2020

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

por Koenis, Duco Steven, Medzikovic, Lejla, van Loenen, Pieter Bas, van Weeghel, Michel, Huveneers, Stephan, Vos, Mariska, Evers-van Gogh, Ingrid Johanna, Van den Bossche, Jan, Speijer, Dave, Kim, Yongsoo, Wessels, Lodewyk, Zelcer, Noam, Zwart, Wilbert, Kalkhoven, Eric, de Vries, Carlie Jacoba
Publicado 2018

Myeloid Ezh2 Deficiency Limits Atherosclerosis Development

por Neele, Annette E., Chen, Hung-Jen, Gijbels, Marion J. J., van der Velden, Saskia, Hoeksema, Marten A., Boshuizen, Marieke C. S., Van den Bossche, Jan, Tool, Anton T., Matlung, Hanke L., van den Berg, Timo K., Lutgens, Esther, de Winther, Menno P. J.
Publicado 2021

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

por Verberk, Sanne G. S., van der Zande, Hendrik J. P., Baardman, Jeroen, de Goede, Kyra E., Harber, Karl J., Keuning, Eelco D., Lambooij, Joost M., Otto, Frank, Zawistowska-Deniziak, Anna, de Vries, Helga E., de Winther, Menno P. J., Guigas, Bruno, Van den Bossche, Jan
Publicado 2021

COVID19 Impairs Cardiac Function via Endothelial H19 and IL6 Signaling

por Juni, Rio P., Phelp, Philippa G., Bink, Diewertje I., Kremer, Veerle, van Bergen, Anke S., Espinosa Gonzalez, Pedro, Rombouts, Karlijn B., Harber, Karl J., Heister, Daan A.F., Yeung, Kak K., Van den Bossche, Jan, Kuster, Diederik W.D., Krijnen, Paul A.J., Niessen, Hans W.M., Boon, Reinier A.
Publicado 2023

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

por Luque-Martin, Rosario, Van den Bossche, Jan, Furze, Rebecca C., Neele, Annette E., van der Velden, Saskia, Gijbels, Marion J.J., van Roomen, Cindy P.P.A., Bernard, Sharon G., de Jonge, Wouter J., Rioja, Inmaculada, Prinjha, Rab K., Lewis, Huw D., Mander, Palwinder K., de Winther, Menno P.J.
Publicado 2019

BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality

por Boon, Mariëtte R., van den Berg, Sjoerd A. A., Wang, Yanan, van den Bossche, Jan, Karkampouna, Sofia, Bauwens, Matthias, De Saint-Hubert, Marijke, van der Horst, Geertje, Vukicevic, Slobodan, de Winther, Menno P. J., Havekes, Louis M., Jukema, J. Wouter, Tamsma, Jouke T., van der Pluijm, Gabri, van Dijk, Ko Willems, Rensen, Patrick C. N.
Publicado 2013

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

por Bosmans, Laura A, van Tiel, Claudia M, Aarts, Suzanne A B M, Willemsen, Lisa, Baardman, Jeroen, van Os, Bram W, den Toom, Myrthe, Beckers, Linda, Ahern, David J, Levels, Johannes H M, Jongejan, Aldo, Moerland, Perry D, Verberk, Sanne G S, van den Bossche, Jan, de Winther, Menno M P J, Weber, Christian, Atzler, Dorothee, Monaco, Claudia, Gerdes, Norbert, Shami, Annelie, Lutgens, Esther
Publicado 2022